Cotl1 MGI Mouse Gene Detail - MGI:1919292 - coactosin like F-actin binding protein 1

Symbol

Cotl1
Name

coactosin like F-actin binding protein 1
Synonyms

1810074P22Rik, 2010004C08Rik

Feature Type

protein coding gene
IDs

MGI:1919292
NCBI Gene: 72042
Alliance

genome feature page
Transcription Start Sites

19 TSS

Sequence Map

Chr8:120535961-120567283 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 68.42 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

1004 from dbSNP Build 142
Strain Annotations

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919292	protein coding gene	Chr8:120535953-120567318 (-)
129S1/SvImJ	ENSMUSG00200040686	protein coding gene	Chr8:114876728-114908056 (-)
A/J	ENSMUSG00195025356	protein coding gene	Chr8:115161693-115193027 (-)
AKR/J	ENSMUSG00220042439	protein coding gene	Chr8:115352032-115383359 (-)
BALB/cJ	ENSMUSG00180024593	protein coding gene	Chr8:115207559-115238881 (-)
C3H/HeJ	ENSMUSG00175026269	protein coding gene	Chr8:115263988-115295314 (-)
C57BL/6NJ	ENSMUSG00215030680	protein coding gene	Chr8:114837767-114869099 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031629	protein coding gene	Chr8:110981166-111011371 (-)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210033476	protein coding gene	Chr8:115191351-115222673 (-)
DBA/2J	ENSMUSG00185017605	protein coding gene	Chr8:121295322-121326648 (-)
FVB/NJ	ENSMUSG00205017433	protein coding gene	Chr8:114172227-114203558 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230025032	protein coding gene	Chr8:124930061-124961384 (-)
NOD/ShiLtJ	ENSMUSG00190017261	protein coding gene	Chr8:115305827-115337151 (-)
NZO/HlLtJ	ENSMUSG00225041936	protein coding gene	Chr8:128296058-128327382 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

COTL1, coactosin like F-actin binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COTL1, coactosin like F-actin binding protein 1
Synonyms

CLP
Links

HGNC:18304

NCBI Gene ID: 23406

UniProt: Q14019
Chr Location

16q24.1; chr16:84565596-84618078 (-) GRCh38

MGI Vertebrate Homology

Cotl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COTL1
Gene Tree

Cotl1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

4
Gene trapped

22
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Cotl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

27
cDNA Data

144
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cotl1

ZFIN cotl1

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All Sequences

52
RefSeq

2
UniProt

3
CCDS

CCDS22712.1

Ensembl

ENSMUSG00000031827 (Evidence)
NCBI Gene

72042

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031827	Ensembl Gene Model \| MGI Sequence Detail	31323	C57BL/6J	± kb
transcript	ENSMUST00000034285	Ensembl \| MGI Sequence Detail	1596	Not Applicable
polypeptide	ENSMUSP00000034285	Ensembl \| MGI Sequence Detail	142	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005768 coactosin-like protein

(term hierarchy)
PDB

1UDM, 1WM4
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily
GlyGen

Q9CQI6 1 site, 1 O-linked glycan (1 site)

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All nucleic 145

cDNA 144

Primer pair 1

Microarray probesets 7

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MGI:1914268

Summaries

All 51

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:365352 Park E, et al., Coactosin-like F-actin binding protein (Cotl1) plays a key role in adipocyte differentiation and obesity. Commun Biol. 2025 Apr 17;8(1):628

TSS for Cotl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83175	Chr8:120567319-120567323 (-)	-38 bp
Tssr83174	Chr8:120567306-120567309 (-)	-25 bp
Tssr83173	Chr8:120567270-120567288 (-)	4 bp
Tssr83172	Chr8:120566924-120566962 (-)	340 bp
Tssr83171	Chr8:120563420-120563443 (-)	3,851 bp
Tssr83170	Chr8:120561152-120561164 (-)	6,125 bp
Tssr83169	Chr8:120560961-120560991 (-)	6,307 bp
Tssr83168	Chr8:120560251-120560277 (-)	7,019 bp
Tssr83167	Chr8:120557352-120557363 (-)	9,925 bp
Tssr83166	Chr8:120554977-120555015 (-)	12,287 bp
Tssr83165	Chr8:120549474-120549491 (-)	17,800 bp
Tssr83164	Chr8:120549442-120549463 (-)	17,830 bp
Tssr83163	Chr8:120537069-120537086 (-)	30,205 bp
Tssr83162	Chr8:120537002-120537020 (-)	30,272 bp
Tssr83161	Chr8:120536955-120536966 (-)	30,322 bp
Tssr83160	Chr8:120536924-120536942 (-)	30,350 bp
Tssr83159	Chr8:120536827-120536875 (-)	30,432 bp
Tssr83158	Chr8:120536772-120536818 (-)	30,488 bp
Tssr83157	Chr8:120536692-120536707 (-)	30,583 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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