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Mccc1
Gene Detail
Symbol

Name
ID
Mccc1
methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
MGI:1919289
Synonyms
1810045E08Rik, 2310058B18Rik, MCCA, MCCalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 3
17.41 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:35959312-36000678 bp, - strand
From VEGA annotation of GRCm38

  41367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10603  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MCCC1
Gene Tree: Mccc1

Human
homologs
MCCC1, methylcrotonoyl-CoA carboxylase 1 (alpha)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56922
neXtProt AC: NX_Q96RQ3

Human Synonyms: MCCA, MCC-B

Human Chr (Location): 3q27; chr3:183015218-183099587 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MCCC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Mccc1 interacts with 233 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process metabolic process
Component 3-methylcrotonyl-CoA carboxylase complex, mitochondrial, mitochondrial inner membrane, ...
Function ATP binding, biotin carboxylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mccc1    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000029224 (Evidence)
Ensembl Gene Model ENSMUSG00000027709 (Evidence)
Entrez Gene 72039 (Evidence)
DFCI TC1576087, TC1620608, TC1756738
DoTS DT.101281596, DT.101733111, DT.111052336, DT.111052361, DT.492220, DT.55128156, DT.99861208
EC 6.4.1.4
Consensus CDS Project CCDS17307.1
International Mouse Phenotyping Consortium Status Mccc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029224 VEGA Gene Model | MGI Sequence Detail 41367 C57BL/6J ±  kb
transcript OTTMUST00000072440 VEGA | MGI Sequence Detail 2455 Not Applicable 
polypeptide OTTMUSP00000037295 VEGA | MGI Sequence Detail 717 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(469 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR001882 Biotin-binding site
InterPro IPR005482 Biotin carboxylase, C-terminal
InterPro IPR005481 Biotin carboxylase-like, N-terminal domain
InterPro IPR011764 Biotin carboxylation domain
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR011054 Rudiment single hybrid motif
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000010233 methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:1917422, MGI:2140108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory