Hhipl1 MGI Mouse Gene Detail - MGI:1919265 - hedgehog interacting protein-like 1

Symbol

Hhipl1
Name

hedgehog interacting protein-like 1
Synonyms

1600002O04Rik, mKIAA1822

Feature Type

protein coding gene
IDs

MGI:1919265
NCBI Gene: 214305
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr12:108272100-108294559 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 59.37 cM
Mapping Data

2 experiments

SNPs within 2kb

217 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919265	protein coding gene	Chr12:108272100-108297128 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020103	protein coding gene	Chr12:110406695-110439784 (+)
A/J	MGP_AJ_G0020057	protein coding gene	Chr12:106235319-106258583 (+)
AKR/J	MGP_AKRJ_G0020033	protein coding gene	Chr12:109315263-109348524 (+)
BALB/cJ	MGP_BALBcJ_G0020043	protein coding gene	Chr12:106646354-106670148 (+)
C3H/HeJ	MGP_C3HHeJ_G0019845	protein coding gene	Chr12:109750777-109780785 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020488	protein coding gene	Chr12:113801337-113830190 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018100	protein coding gene	Chr12:102772832-102796122 (+)
CAST/EiJ	MGP_CASTEiJ_G0019387	protein coding gene	Chr12:104686260-104713607 (+)
CBA/J	MGP_CBAJ_G0019812	protein coding gene	Chr12:118327447-118364967 (+)
DBA/2J	MGP_DBA2J_G0019929	protein coding gene	Chr12:105762807-105791309 (+)
FVB/NJ	MGP_FVBNJ_G0019914	protein coding gene	Chr12:104547056-104573423 (+)
LP/J	MGP_LPJ_G0020004	protein coding gene	Chr12:110285228-110310716 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019952	protein coding gene	Chr12:121536971-121564996 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020517	protein coding gene	Chr12:108774167-108804566 (+)
PWK/PhJ	MGP_PWKPhJ_G0019146	protein coding gene	Chr12:100377817-100403623 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018950	protein coding gene	Chr12:102990674-103014423 (+)
WSB/EiJ	MGP_WSBEiJ_G0019444	protein coding gene	Chr12:109712563-109743324 (+)

Human Ortholog

HHIPL1, HHIP like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HHIPL1, HHIP like 1
Synonyms

KIAA1822, UNQ9245
Links

HGNC:19710

NCBI Gene ID: 84439

neXtProt AC: NX_Q96JK4

UniProt: Q96JK4
Chr Location

14q32.2; chr14:99604538-99680569 (+) GRCh38

MGI Vertebrate Homology

Hhipl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HHIPL1
Gene Tree

Hhipl1

less

Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and overtly normal but show reduced in vitro proliferation and migration of aortic smooth muscle cells.

less

All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

12
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hhipl1

less

All Sequences

37
RefSeq

4
UniProt

1
CCDS

CCDS36554.1

Ensembl

ENSMUSG00000021260 (Evidence)
NCBI Gene

214305

			Length	Strain/Species	Flank
genomic	214305	NCBI Gene Model \| MGI Sequence Detail	22460	C57BL/6J	± kb
transcript	NM_001044380	RefSeq \| MGI Sequence Detail	2605	Not Specified
polypeptide	Q14DK5	UniProt \| EBI \| MGI Sequence Detail	791	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000008542 HHIP-like protein 1

(term hierarchy)
InterPro Domains

IPR018143 Folate receptor-like

IPR012938 Glucose/Sorbosone dehydrogenase

IPR011042 Six-bladed beta-propeller, TolB-like

IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase

IPR001190 SRCR domain

IPR017448 SRCR-like domain

IPR036772 SRCR-like domain superfamily

less

All nucleic 14

cDNA 14

Microarray probesets 3

less

MGI:2679729

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:280707 Aravani D, et al., HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. Circulation. 2019 Aug 6;140(6):500-513

TSS for Hhipl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114959	Chr12:108272250-108272262 (+)	156 bp
Tssr114960	Chr12:108272443-108272462 (+)	353 bp
Tssr114961	Chr12:108272639-108272661 (+)	550 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23