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Fndc3b Gene Detail
Summary
  • Symbol
    Fndc3b
  • Name
    fibronectin type III domain containing 3B
  • Synonyms
    1600019O04Rik, fad104
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919257
    NCBI Gene: 72007
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27416162-27711307 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1893 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919257
protein coding gene Chr3:27416161-27713112 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027112
protein coding gene Chr3:24735037-25053749 (-)
A/J MGP_AJ_G0027072
protein coding gene Chr3:24547879-24845806 (-)
AKR/J MGP_AKRJ_G0027041
protein coding gene Chr3:24864848-25176372 (-)
BALB/cJ MGP_BALBcJ_G0027084
protein coding gene Chr3:24226810-24532280 (-)
C3H/HeJ MGP_C3HHeJ_G0026825
protein coding gene Chr3:24902526-25211754 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027529
protein coding gene Chr3:26110686-26430809 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024891
protein coding gene Chr3:22558368-22852458 (-)
CAST/EiJ MGP_CASTEiJ_G0026280
protein coding gene Chr3:24737735-25056022 (-)
CBA/J MGP_CBAJ_G0026803
protein coding gene Chr3:26788692-27134616 (-)
DBA/2J MGP_DBA2J_G0026937
protein coding gene Chr3:24095938-24394516 (-)
FVB/NJ MGP_FVBNJ_G0026905
protein coding gene Chr3:23569660-23867479 (-)
LP/J MGP_LPJ_G0027049
protein coding gene Chr3:25413482-25725031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026926
protein coding gene Chr3:29369938-29694613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027589
protein coding gene Chr3:24578667-24897565 (-)
PWK/PhJ MGP_PWKPhJ_G0026013
protein coding gene Chr3:23554474-23861896 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025823
protein coding gene Chr3:24110792-24428698 (-)
WSB/EiJ MGP_WSBEiJ_G0026353
protein coding gene Chr3:24626418-24947937 (-)



Homology
more
  • Human Ortholog
    FNDC3B, fibronectin type III domain containing 3B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FNDC3B, fibronectin type III domain containing 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAD104, PRO4979, YVTM2421
  • Links
    NCBI Gene ID: 64778
    neXtProt AC: NX_Q53EP0
    UniProt: Q53EP0

  • Chr Location
    3q26.31; chr3:172039628-172400703 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11244
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FNDC3B
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039286 Ensembl Gene Model | MGI Sequence Detail 295146 C57BL/6J ±  kb
transcript ENSMUST00000195008 Ensembl | MGI Sequence Detail 6886 Not Applicable  
polypeptide ENSMUSP00000141620 Ensembl | MGI Sequence Detail 1207 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140001
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204896 Kishimoto K, et al., FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation. J Biol Chem. 2013 Nov 1;288(44):31772-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory