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Fndc3b Gene Detail
Summary
  • Symbol
    Fndc3b
  • Name
    fibronectin type III domain containing 3B
  • Synonyms
    1600019O04Rik, fad104
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919257
    NCBI Gene: 72007
Location & Maps
more
  • Sequence Map
    Chr3:27416162-27711307 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      295146 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.91 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FNDC3B, fibronectin type III domain containing 3B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FNDC3B, fibronectin type III domain containing 3B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FAD104, PRO4979, YVTM2421
  • Links
    NCBI Gene ID: 64778
    neXtProt AC: NX_Q53EP0

  • Chr Location
    3q26.31; chr3:172039628-172400703 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    133
  • Gene trapped
    126
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Fndc3b
  • Incidental Mutations
Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051189 VEGA Gene Model | MGI Sequence Detail 295146 C57BL/6J ±  kb
transcript OTTMUST00000129644 VEGA | MGI Sequence Detail 6886 Not Applicable  
polypeptide OTTMUSP00000069618 VEGA | MGI Sequence Detail 1207 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1893 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140001
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204896 Kishimoto K, et al., FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation. J Biol Chem. 2013 Nov 1;288(44):31772-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory