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Cnn3 Gene Detail
Summary
  • Symbol
    Cnn3
  • Name
    calponin 3, acidic
  • Synonyms
    1600014M03Rik, Calpo3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919244
    NCBI Gene: 71994
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:121426541-121458205 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 52.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    466 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919244
protein coding gene Chr3:121426497-121458207 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027830
protein coding gene Chr3:123616404-123648382 (+)
A/J MGP_AJ_G0027788
protein coding gene Chr3:119497769-119530373 (+)
AKR/J MGP_AKRJ_G0027754
protein coding gene Chr3:122543310-122574838 (+)
BALB/cJ MGP_BALBcJ_G0027800
protein coding gene Chr3:119317153-119348926 (+)
C3H/HeJ MGP_C3HHeJ_G0027531
protein coding gene Chr3:122938056-122970538 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028246
protein coding gene Chr3:128098832-128132734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025585
protein coding gene Chr3:114932082-114963276 (+)
CAST/EiJ MGP_CASTEiJ_G0026987
protein coding gene Chr3:122306676-122341332 (+)
CBA/J MGP_CBAJ_G0027506
protein coding gene Chr3:132428965-132468550 (+)
DBA/2J MGP_DBA2J_G0027647
protein coding gene Chr3:118653910-118686783 (+)
FVB/NJ MGP_FVBNJ_G0027615
protein coding gene Chr3:116262346-116295704 (+)
LP/J MGP_LPJ_G0027757
protein coding gene Chr3:125138710-125172243 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027645
protein coding gene Chr3:140066656-140098200 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028302
protein coding gene Chr3:122093030-122127805 (+)
PWK/PhJ MGP_PWKPhJ_G0026713
protein coding gene Chr3:118346691-118379106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026536
protein coding gene Chr3:120165518-120196347 (+)
WSB/EiJ MGP_WSBEiJ_G0027067
protein coding gene Chr3:122807870-122847698 (+)



Homology
more
  • Human Ortholog
    CNN3, calponin 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CNN3, calponin 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 1266
    neXtProt AC: NX_Q15417
    UniProt: Q15417

  • Chr Location
    1p21.3; chr1:94896949-94927223 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37533
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CNN3
  • Protein SuperFamily
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe exencephaly, neuronal tissue overgrowth and die immediately postnatal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71994 NCBI Gene Model | MGI Sequence Detail 31665 C57BL/6J ±  kb
    transcript NM_028044 RefSeq | MGI Sequence Detail 2003 C57BL/6  
    polypeptide Q9DAW9 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 206
      cDNA 205
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2140096
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:255082 Kurogi S, et al., Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Sci Rep. 2017 Jan 20;7:40692

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory