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Sars2
Gene Detail
 Symbol
Name
ID
Sars2
seryl-aminoacyl-tRNA synthetase 2
MGI:1919234
Synonyms 2410015F05Rik, D7Ertd353e
Feature Type protein coding gene
Genetic Map
Chromosome 7
16.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:28741968-28753879 bp, + strand
From NCBI annotation of GRCm38

  11912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6073  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine-tRNA ligase
Gene Tree: Sars2

Human
homologs
Human Homolog SARS2, seryl-tRNA synthetase 2, mitochondrial
NCBI Gene ID 54938
neXtProt AC  NX_Q9NP81
Human Synonyms  mtSerRS, SARS, SARSM, SerRS, SerRSmt, SERS, SYS
Human Chr (Location)  19q13.2; chr19:38915264-38930896 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SARS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from APF )
Interactions
Sars2 interacts with 47 markers (Mir22, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process seryl-tRNA aminoacylation, translation, ...
Component cytoplasm, mitochondrion
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) cDNA(48) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000070699 (Evidence)
Entrez Gene71984 (Evidence)
UniGene333725
DFCITC1578621
DoTSDT.531217, DT.87059269, DT.97360226
NIA Mouse Gene IndexU007883
EC6.1.1.11
Consensus CDS ProjectCCDS21053.1
International Mouse Knockout Project StatusSars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 71984 NCBI Gene Model | MGI Sequence Detail 11912 C57BL/6J ±  kb
transcript NM_023637 RefSeq | MGI Sequence Detail 1910 C57BL/6 
polypeptide Q9JJL8 UniProt | EBI | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
InterPro IPR002317 Serine-tRNA ligase, type1
InterPro IPR015866 Serine-tRNA synthetase, type1, N-terminal
InterPro IPR010978 tRNA-binding arm
Protein Ontology PR:000014460 serine--tRNA ligase, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)
Other
accession IDs
MGI:1196425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory