Sars2
Gene Detail

Symbol Name ID

Sars2 seryl-aminoacyl-tRNA synthetase 2 MGI:1919234

Synonyms

2410015F05Rik, D7Ertd353e

Feature Type

protein coding gene

Genetic Map

Chromosome 7

16.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:28741968-28753879 bp, + strand From NCBI annotation of GRCm38   11912 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6073  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine-tRNA ligase
Gene Tree: Sars2

Human homologs

Human Homolog		SARS2, seryl-tRNA synthetase 2, mitochondrial
NCBI Gene ID		54938
neXtProt AC		NX_Q9NP81
Human Synonyms		mtSerRS, SARS, SARSM, SerRS, SerRSmt, SERS, SYS
Human Chr (Location)		19q13.2; chr19:39405904-39421536 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SARS2

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	seryl-tRNA aminoacylation, translation, ...
Component	cytoplasm, mitochondrion
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) cDNA(48) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000070699 (Evidence)
Entrez Gene	71984 (Evidence)
UniGene	333725
DFCI	TC1578621
DoTS	DT.531217, DT.87059269, DT.97360226
NIA Mouse Gene Index	U007883
EC	6.1.1.11
Consensus CDS Project	CCDS21053.1
International Mouse Knockout Project Status	Sars2

Sequences

Length	Strain/Species
genomic	71984	NCBI Gene Model | MGI Sequence Detail	11912	C57BL/6J
transcript	NM_023637	RefSeq | MGI Sequence Detail	1910	C57BL/6
polypeptide	Q9JJL8	UniProt | EBI | MGI Sequence Detail	518	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(72 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006195	Aminoacyl-tRNA synthetase, class II
InterPro	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
InterPro	IPR002317	Serine-tRNA ligase, type1
InterPro	IPR015866	Serine-tRNA synthetase, type1, N-terminal
InterPro	IPR010978	tRNA-binding arm
Protein Ontology	PR:000014460	seryl-tRNA synthetase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Other accession IDs

MGI:1196425