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Snx10 Gene Detail
Summary
  • Symbol
    Snx10
  • Name
    sorting nexin 10
  • Synonyms
    2410004M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919232
    NCBI Gene: 71982
  • Gene Overview
    MyGene.info: SNX10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:51523901-51590679 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.95 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SNX10, sorting nexin 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNX10, sorting nexin 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OPTB8
  • Links
    NCBI Gene ID: 29887
    neXtProt AC: NX_Q9Y5X0
    UniProt: Q9Y5X0

  • Chr Location
    7p15.2; chr7:26291895-26374330 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SNX10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    10 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele show postnatal growth retardation, failure of tooth eruption, impaired skeleton development, and osteopetrorickets associated with failed osteoclast activity, high stomach pH, low calcium availability, impaired bone mineralization, and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023330 VEGA Gene Model | MGI Sequence Detail 66779 C57BL/6J ±  kb
    transcript OTTMUST00000056532 VEGA | MGI Sequence Detail 2480 Not Applicable  
    polypeptide OTTMUSP00000027182 VEGA | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      317 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR001683 Phox homologous domain
      IPR036871 PX domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 123
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:224711 Ye L, et al., Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet. 2015 Mar;11(3):e1005057

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory