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Snx10 Gene Detail
Summary
  • Symbol
    Snx10
  • Name
    sorting nexin 10
  • Synonyms
    2410004M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919232
    NCBI Gene: 71982
  • Gene Overview
    MyGene.info: SNX10
Location & Maps
more
  • Sequence Map
    Chr6:51523901-51590679 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.95 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SNX10, sorting nexin 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNX10, sorting nexin 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OPTB8
  • Links
    NCBI Gene ID: 29887
    neXtProt AC: NX_Q9Y5X0

  • Chr Location
    7p15.2; chr7:26291895-26374383 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SNX10 associations

Human Disease Mouse Models
       Osteopetrosis, Autosomal Recessive 8; OPTB8   OMIM: 615085
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    10 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    278
  • Gene trapped
    272
  • Targeted
    6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023330 VEGA Gene Model | MGI Sequence Detail 66779 C57BL/6J ±  kb
transcript OTTMUST00000056535 VEGA | MGI Sequence Detail 968 Not Applicable  
polypeptide OTTMUSP00000027183 VEGA | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    317 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000015359 sorting nexin-10
  • InterPro Domains
    IPR001683 Phox homologous domain
Molecular
Reagents
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  • All nucleic 125
    cDNA 123
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224711 Ye L, et al., Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet. 2015 Mar;11(3):e1005057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory