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Ppp2r2a Gene Detail
Summary
  • Symbol
    Ppp2r2a
  • Name
    protein phosphatase 2, regulatory subunit B, alpha
  • Synonyms
    2410004D02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919228
    NCBI Gene: 71978
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67251505-67309893 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1133 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919228
 protein coding gene Chr14:67251505-67309920 (-)
129S1/SvImJ ENSMUSG00200029033
 protein coding gene Chr14:55867039-55925565 (-)
A/J ENSMUSG00195013112
 protein coding gene Chr14:56032553-56091078 (-)
AKR/J ENSMUSG00220028680
 protein coding gene Chr14:55373249-55431773 (-)
BALB/cJ ENSMUSG00180031466
 protein coding gene Chr14:55648749-55707259 (-)
C3H/HeJ ENSMUSG00175035901
 protein coding gene Chr14:57403511-57462042 (-)
C57BL/6NJ ENSMUSG00215015667
 protein coding gene Chr14:55586368-55644761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019446
 protein coding gene Chr14:58152356-58210999 (-)
CAST/EiJ ENSTCUG00005038098
 protein coding gene Chr14:57289714-57348319 (-)
CBA/J ENSMUSG00210038700
 protein coding gene Chr14:56021322-56079829 (-)
DBA/2J ENSMUSG00185022608
 protein coding gene Chr14:61201338-61259871 (-)
FVB/NJ ENSMUSG00205020386
 protein coding gene Chr14:55535379-55593894 (-)
JF1/MsJ ENSUMUG00000024382
 protein coding gene Chr14:72360429-72419020 (-)
LP/J ENSMUSG00230032116
 protein coding gene Chr14:73230545-73289073 (-)
NOD/ShiLtJ ENSMUSG00190038208
 protein coding gene Chr14:55814531-55873046 (-)
NZO/HlLtJ ENSMUSG00225038542
 protein coding gene Chr14:63547400-63605927 (-)
PWK/PhJ ENSLUMG00010033813
 protein coding gene Chr14:55237066-55295702 (-)
SPRET/EiJ ENSMSPG00010028908
 protein coding gene Chr14:58751760-58810313 (-)
WSB/EiJ ENSIUOG00005038114
 protein coding gene Chr14:55258461-55317100 (-)



Homology
more
  • Human Ortholog
    PPP2R2A, protein phosphatase 2 regulatory subunit Balpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R2A, protein phosphatase 2 regulatory subunit Balpha
  • Synonyms
    B55, B55A, B55ALPHA, PR52A, PR55A, PR55alpha
  • Links
    NCBI Gene ID: 5520
    UniProt: P63151

  • Chr Location
    8p21.2; chr8:26291508-26372680 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for an ENU-induced hypomorphic allele exhibit increased circulating insulin level and pancreatic beta cell mas and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    14
  • cDNA Data
    151
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022052 Ensembl Gene Model | MGI Sequence Detail 58389 C57BL/6J ±  kb
    transcript ENSMUST00000089230 Ensembl | MGI Sequence Detail 4010 Not Applicable  
    polypeptide ENSMUSP00000086640 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003213 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
      (term hierarchy)
    • InterPro Domains
      IPR000009 Protein phosphatase 2A regulatory subunit PR55
      IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q6P1F6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 151
      Primer pair 2
      Antibodies 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390659 Pan W, et al., The PP2A regulatory subunit PPP2R2A controls NAD(+) biosynthesis to regulate T cell subset differentiation in systemic autoimmunity. Cell Rep. 2024 Jun 17;43(7):114379
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory