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Ppp2r2a Gene Detail
Summary
  • Symbol
    Ppp2r2a
  • Name
    protein phosphatase 2, regulatory subunit B, alpha
  • Synonyms
    2410004D02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919228
    NCBI Gene: 71978
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67251505-67309893 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    281 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919228
 protein coding gene Chr14:67251505-67309920 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021502
 protein coding gene Chr14:61725968-61789534 (-)
A/J MGP_AJ_G0021461
 protein coding gene Chr14:60230800-60290422 (-)
AKR/J MGP_AKRJ_G0021437
 protein coding gene Chr14:62302546-62366600 (-)
BALB/cJ MGP_BALBcJ_G0021467
 protein coding gene Chr14:60239700-60298450 (-)
C3H/HeJ MGP_C3HHeJ_G0021244
 protein coding gene Chr14:62032735-62101591 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021906
 protein coding gene Chr14:64541896-64604428 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019446
 protein coding gene Chr14:58152356-58210999 (-)
CAST/EiJ MGP_CASTEiJ_G0020761
 protein coding gene Chr14:58507788-58568226 (-)
CBA/J MGP_CBAJ_G0021211
 protein coding gene Chr14:66524855-66591935 (-)
DBA/2J MGP_DBA2J_G0021334
 protein coding gene Chr14:59883899-59942567 (-)
FVB/NJ MGP_FVBNJ_G0021313
 protein coding gene Chr14:59289039-59347188 (-)
LP/J MGP_LPJ_G0021409
 protein coding gene Chr14:62777365-62841384 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021342
 protein coding gene Chr14:65536089-65595752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021929
 protein coding gene Chr14:61533403-61594785 (-)
PWK/PhJ MGP_PWKPhJ_G0020505
 protein coding gene Chr14:56624661-56685939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020338
 protein coding gene Chr14:57494424-57557500 (-)
WSB/EiJ MGP_WSBEiJ_G0020814
 protein coding gene Chr14:61855832-61919184 (-)



Homology
more
  • Human Ortholog
    PPP2R2A, protein phosphatase 2 regulatory subunit Balpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R2A, protein phosphatase 2 regulatory subunit Balpha
  • Synonyms
    B55A, B55ALPHA, PR52A, PR55A, PR55alpha
  • Links
    NCBI Gene ID: 5520
    neXtProt AC: NX_P63151
    UniProt: P63151

  • Chr Location
    8p21.2; chr8:26291508-26372680 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for an ENU-induced hypomorphic allele exhibit increased circulating insulin level and pancreatic beta cell mas and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    14
  • cDNA Data
    151
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022052 Ensembl Gene Model | MGI Sequence Detail 58389 C57BL/6J ±  kb
    transcript ENSMUST00000089230 Ensembl | MGI Sequence Detail 4010 Not Applicable  
    polypeptide ENSMUSP00000086640 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003213 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
      (term hierarchy)
    • InterPro Domains
      IPR000009 Protein phosphatase 2A regulatory subunit PR55
      IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 151
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:307962 Pan W, et al., The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway. J Immunol. 2021 Apr 15;206(8):1719-1728
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory