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Prmt3 Gene Detail
Summary
  • Symbol
    Prmt3
  • Name
    protein arginine N-methyltransferase 3
  • Synonyms
    2010005E20Rik, 2410018A17Rik, Hrmt1l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919224
    NCBI Gene: 71974
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:49428094-49508013 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 31.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    590 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919224
protein coding gene Chr7:49428067-49508016 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032300
protein coding gene Chr7:50457337-50543354 (+)
A/J MGP_AJ_G0032279
protein coding gene Chr7:49695270-49775097 (+)
AKR/J MGP_AKRJ_G0032215
protein coding gene Chr7:50893545-50973407 (+)
BALB/cJ MGP_BALBcJ_G0032291
protein coding gene Chr7:49360228-49444538 (+)
C3H/HeJ MGP_C3HHeJ_G0032004
protein coding gene Chr7:51254333-51337884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032784
protein coding gene Chr7:52761651-52843944 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029790
protein coding gene Chr7:52867423-52951821 (+)
CAST/EiJ MGP_CASTEiJ_G0031332
protein coding gene Chr7:42665432-42747645 (+)
CBA/J MGP_CBAJ_G0031969
protein coding gene Chr7:54548921-54635581 (+)
DBA/2J MGP_DBA2J_G0032126
protein coding gene Chr7:48919734-48999864 (+)
FVB/NJ MGP_FVBNJ_G0032080
protein coding gene Chr7:48852492-48934247 (+)
LP/J MGP_LPJ_G0032207
protein coding gene Chr7:51397826-51481140 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032117
protein coding gene Chr7:53644847-53727389 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032801
protein coding gene Chr7:49862192-49947245 (+)
PWK/PhJ MGP_PWKPhJ_G0031052
protein coding gene Chr7:42259820-42338017 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030893
protein coding gene Chr7:38038686-38121651 (+)
WSB/EiJ MGP_WSBEiJ_G0031450
protein coding gene Chr7:50524777-50604977 (+)



Homology
more
  • Human Ortholog
    PRMT3, protein arginine methyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRMT3, protein arginine methyltransferase 3
  • Synonyms
    HRMT1L3
  • Links
    NCBI Gene ID: 10196
    neXtProt AC: NX_O60678
    UniProt: O60678

  • Chr Location
    11p15.1; chr11:20387558-20509338 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic gene trap allele exhibit a reduced embryonic size but survive birth and attain a normal size in adulthood.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030505 Ensembl Gene Model | MGI Sequence Detail 79920 C57BL/6J ±  kb
    transcript ENSMUST00000032715 Ensembl | MGI Sequence Detail 2507 Not Applicable  
    polypeptide ENSMUSP00000032715 Ensembl | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917085, MGI:2142102
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340068 Wang Y, et al., Protein arginine methyltransferase 3 inhibits renal tubulointerstitial fibrosis through asymmetric dimethylarginine. Front Med (Lausanne). 2022;9:995917

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory