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Prmt3 Gene Detail
Summary
  • Symbol
    Prmt3
  • Name
    protein arginine N-methyltransferase 3
  • Synonyms
    2010005E20Rik, 2410018A17Rik, Hrmt1l3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919224
    NCBI Gene: 71974
  • Gene Overview
    MyGene.info: PRMT3
Location & Maps
more
  • Sequence Map
    Chr7:49778346-49858265 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79920 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRMT3, protein arginine methyltransferase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRMT3, protein arginine methyltransferase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HRMT1L3
  • Links
    NCBI Gene ID: 10196
    neXtProt AC: NX_O60678

  • Chr Location
    11p15.1; chr11:20387530-20509333 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    9
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a hypomorphic gene trap allele exhibit a reduced embryonic size but survive birth and attain a normal size in adulthood.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020564 VEGA Gene Model | MGI Sequence Detail 79920 C57BL/6J ±  kb
transcript OTTMUST00000048733 VEGA | MGI Sequence Detail 2507 Not Applicable  
polypeptide OTTMUSP00000022425 VEGA | MGI Sequence Detail 528 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    590 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013254 protein arginine N-methyltransferase 3
  • PDB
  • EC
  • InterPro Domains
    IPR025799 Protein arginine N-methyltransferase
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    IPR015880 Zinc finger, C2H2-like
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1917085, MGI:2142102
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory