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Nkiras2 Gene Detail
Summary
  • Symbol
    Nkiras2
  • Name
    NFKB inhibitor interacting Ras-like protein 2
  • Synonyms
    2410003M04Rik, 4930527H08Rik, KBRAS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919216
    NCBI Gene: 71966
  • Gene Overview
    MyGene.info: NKIRAS2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100619856-100627610 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919216
protein coding gene Chr11:100619244-100627610 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019162
protein coding gene Chr11:103385901-103394314 (+)
A/J MGP_AJ_G0019130
protein coding gene Chr11:99070613-99078975 (+)
AKR/J MGP_AKRJ_G0019099
protein coding gene Chr11:102135894-102144305 (+)
BALB/cJ MGP_BALBcJ_G0019104
protein coding gene Chr11:99554955-99563315 (+)
C3H/HeJ MGP_C3HHeJ_G0018913
protein coding gene Chr11:102318776-102327452 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019553
protein coding gene Chr11:106599767-106608104 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017179
protein coding gene Chr11:96491061-96499452 (+)
CAST/EiJ MGP_CASTEiJ_G0018467
protein coding gene Chr11:103298015-103305826 (+)
CBA/J MGP_CBAJ_G0018882
protein coding gene Chr11:111037604-111050339 (+)
DBA/2J MGP_DBA2J_G0018994
protein coding gene Chr11:98607423-98616001 (+)
FVB/NJ MGP_FVBNJ_G0018984
protein coding gene Chr11:98143572-98152894 (+)
LP/J MGP_LPJ_G0019063
protein coding gene Chr11:103947545-103956701 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019015
protein coding gene Chr11:110638304-110647540 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019591
protein coding gene Chr11:102467172-102475536 (+)
PWK/PhJ MGP_PWKPhJ_G0018230
protein coding gene Chr11:99648553-99656953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018022
protein coding gene Chr11:102207105-102217396 (+)
WSB/EiJ MGP_WSBEiJ_G0018516
protein coding gene Chr11:102450970-102459131 (+)



Homology
more
  • Human Ortholog
    NKIRAS2, NFKB inhibitor interacting Ras like 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NKIRAS2, NFKB inhibitor interacting Ras like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    kappaB-Ras2, KBRAS2
  • Links
    NCBI Gene ID: 28511
    neXtProt AC: NX_Q9NYR9
    UniProt: Q9NYR9

  • Chr Location
    17q21.2; chr17:42017576-42025641 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71966 NCBI Gene Model | MGI Sequence Detail 7755 C57BL/6J ±  kb
transcript NM_028024 RefSeq | MGI Sequence Detail 2013 C57BL/6  
polypeptide Q9CR56 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase
    IPR020849 Small GTPase superfamily, Ras-type
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:1922407
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory