About   Help   FAQ
Nkiras2
Gene Detail
Symbol

Name
ID
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
MGI:1919216
Synonyms
2410003M04Rik, 4930527H08Rik, KBRAS2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:100619244-100627607 bp, + strand
From VEGA annotation of GRCm38

  8364 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NKIRAS2
Protein SuperFamily: Ras-related protein Rab
Gene Tree: Nkiras2

Human
homologs
NKIRAS2, NFKB inhibitor interacting Ras-like 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 28511
neXtProt AC: NX_Q9NYR9

Human Synonyms: kappaB-Ras2, KBRAS2

Human Chr (Location): 17q21.2; chr17:42017561-42025641 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Targeted(3)
Genomic Mutations involving Nkiras2 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nkiras2 interacts with 198 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process signal transduction, small GTPase mediated signal transduction
Component cytoplasm, membrane
Function GTP binding, nucleotide binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (15)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 16
Western blot 18
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nkiras2    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002025 (Evidence)
Ensembl Gene Model ENSMUSG00000017837 (Evidence)
Entrez Gene 71966 (Evidence)
DFCI TC1572015
NIA Mouse Gene Index U013343
Consensus CDS Project CCDS25429.1
International Mouse Phenotyping Consortium Status Nkiras2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002025 VEGA Gene Model | MGI Sequence Detail 8364 C57BL/6J ±  kb
transcript OTTMUST00000004105 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000001970 VEGA | MGI Sequence Detail 191 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR020849 Small GTPase superfamily, Ras type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000011236 NF-kappa-B inhibitor-interacting Ras-like protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:1922407

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory