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Ist1 Gene Detail
Summary
  • Symbol
    Ist1
  • Name
    IST1 factor associated with ESCRT-III
  • Synonyms
    2400003C14Rik, mKIAA0174
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919205
    NCBI Gene: 71955
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110397957-110419892 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    586 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919205
 protein coding gene Chr8:110397953-110419929 (-)
129S1/SvImJ ENSMUSG00200014537
 protein coding gene Chr8:104699669-104721606 (-)
A/J ENSMUSG00195020350
 protein coding gene Chr8:105012238-105034177 (-)
AKR/J ENSMUSG00220014532
 protein coding gene Chr8:105154607-105176548 (-)
BALB/cJ ENSMUSG00180017818
 protein coding gene Chr8:105017936-105039876 (-)
C3H/HeJ ENSMUSG00175021953
 protein coding gene Chr8:105074605-105096541 (-)
C57BL/6NJ ENSMUSG00215033046
 protein coding gene Chr8:104678349-104700286 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031546
 protein coding gene Chr8:100761815-100784538 (-)
CAST/EiJ ENSTCUG00005034059
 protein coding gene Chr8:104422298-104443843 (-)
CBA/J ENSMUSG00210028930
 protein coding gene Chr8:105001821-105023758 (-)
DBA/2J ENSMUSG00185005092
 protein coding gene Chr8:111110838-111132776 (-)
FVB/NJ ENSMUSG00205016082
 protein coding gene Chr8:104007852-104029789 (-)
JF1/MsJ ENSUMUG00000008513
 protein coding gene Chr8:113444175-113466112 (-)
LP/J ENSMUSG00230031109
 protein coding gene Chr8:114790837-114812773 (-)
NOD/ShiLtJ ENSMUSG00190023080
 protein coding gene Chr8:105146589-105168526 (-)
NZO/HlLtJ ENSMUSG00225022706
 protein coding gene Chr8:118141522-118163459 (-)
PWK/PhJ ENSLUMG00010025987
 protein coding gene Chr8:104897909-104919961 (-)
SPRET/EiJ ENSMSPG00010029548
 protein coding gene Chr8:106982463-107001570 (-)
WSB/EiJ ENSIUOG00005029360
 protein coding gene Chr8:105801627-105823507 (-)



Homology
more
  • Human Ortholog
    IST1, IST1 factor associated with ESCRT-III
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IST1, IST1 factor associated with ESCRT-III
  • Synonyms
    CHMP8, OLC1
  • Links
    NCBI Gene ID: 9798
    UniProt: P53990

  • Chr Location
    16q22.2; chr16:71845996-71931199 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    54
  • cDNA Data
    238
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031729 Ensembl Gene Model | MGI Sequence Detail 21936 C57BL/6J ±  kb
    transcript ENSMUST00000034164 Ensembl | MGI Sequence Detail 2304 Not Applicable  
    polypeptide ENSMUSP00000034164 Ensembl | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 240
      cDNA 238
      Primer pair 2
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142793
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory