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Cars2 Gene Detail
Summary
  • Symbol
    Cars2
  • Name
    cysteinyl-tRNA synthetase 2 (mitochondrial)(putative)
  • Synonyms
    2310051N18Rik, 2410044A07Rik, D530030H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919191
    NCBI Gene: 71941
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:11514017-11550778 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919191
protein coding gene Chr8:11513977-11550783 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033355
protein coding gene Chr8:8725828-8765097 (-)
A/J MGP_AJ_G0033335
protein coding gene Chr8:8431611-8470544 (-)
AKR/J MGP_AKRJ_G0033266
protein coding gene Chr8:8682690-8722693 (-)
BALB/cJ MGP_BALBcJ_G0033336
protein coding gene Chr8:8577432-8614302 (-)
C3H/HeJ MGP_C3HHeJ_G0033049
protein coding gene Chr8:8846855-8891201 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033848
protein coding gene Chr8:9076516-9115006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030818
protein coding gene Chr8:7961216-8000246 (-)
CAST/EiJ MGP_CASTEiJ_G0032371
protein coding gene Chr8:8587216-8631633 (-)
CBA/J MGP_CBAJ_G0033022
protein coding gene Chr8:9453505-9508915 (-)
DBA/2J MGP_DBA2J_G0033175
protein coding gene Chr8:8416083-8452431 (-)
FVB/NJ MGP_FVBNJ_G0033124
protein coding gene Chr8:8381742-8419963 (-)
LP/J MGP_LPJ_G0033269
protein coding gene Chr8:8647954-8690616 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033158
protein coding gene Chr8:9766917-9809825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033865
protein coding gene Chr8:8695497-8739049 (-)
PWK/PhJ MGP_PWKPhJ_G0032084
protein coding gene Chr8:8403904-8444191 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031926
protein coding gene Chr8:8610967-8654103 (-)
WSB/EiJ MGP_WSBEiJ_G0032487
protein coding gene Chr8:8733358-8779328 (-)



Homology
more
  • Human Ortholog
    CARS2, cysteinyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CARS2, cysteinyl-tRNA synthetase 2, mitochondrial
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COXPD27, cysRS
  • Links
    NCBI Gene ID: 79587
    neXtProt AC: NX_Q9HA77
    UniProt: Q9HA77

  • Chr Location
    13q34; chr13:110641410-110713527 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11575
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CARS2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele develop induced hyperactivity followed by head bobbing and tremors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71941 NCBI Gene Model | MGI Sequence Detail 36762 C57BL/6J ±  kb
transcript NM_024248 RefSeq | MGI Sequence Detail 1867 C57BL/6  
polypeptide Q8BYM8 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • EC
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR015803 Cysteine-tRNA ligase
    IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR032678 tRNA synthetases class I, catalytic domain
Molecular
Reagents
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  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917241, MGI:1925966
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory