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Tmem123 Gene Detail
Summary
  • Symbol
    Tmem123
  • Name
    transmembrane protein 123
  • Synonyms
    2310075C12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919179
    NCBI Gene: 71929
  • Gene Overview
    MyGene.info: TMEM123
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7764077-7794333 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919179
protein coding gene Chr9:7764041-7794333 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034328
protein coding gene Chr9:4621166-4652791 (+)
A/J MGP_AJ_G0034306
protein coding gene Chr9:4732718-4763694 (+)
AKR/J MGP_AKRJ_G0034234
protein coding gene Chr9:4605067-4636796 (+)
BALB/cJ MGP_BALBcJ_G0034300
protein coding gene Chr9:4478014-4508115 (+)
C3H/HeJ MGP_C3HHeJ_G0034011
protein coding gene Chr9:4792439-4822598 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034822
protein coding gene Chr9:4804069-4834064 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031760
protein coding gene Chr9:3976695-4007338 (+)
CAST/EiJ MGP_CASTEiJ_G0033339
protein coding gene Chr9:4820164-4851918 (+)
CBA/J MGP_CBAJ_G0033984
protein coding gene Chr9:4921815-4951916 (+)
DBA/2J MGP_DBA2J_G0034141
protein coding gene Chr9:4609973-4640829 (+)
FVB/NJ MGP_FVBNJ_G0034086
protein coding gene Chr9:4382990-4414162 (+)
LP/J MGP_LPJ_G0034227
protein coding gene Chr9:4684001-4714932 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034130
protein coding gene Chr9:5668404-5699262 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034841
protein coding gene Chr9:4600234-4630417 (+)
PWK/PhJ MGP_PWKPhJ_G0033042
protein coding gene Chr9:4731672-4762615 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032880
protein coding gene Chr9:4846368-4879033 (+)
WSB/EiJ MGP_WSBEiJ_G0033454
protein coding gene Chr9:4614885-4650761 (+)



Homology
more
  • Human Ortholog
    TMEM123, transmembrane protein 123
  • Vertebrate Orthologs
    5
  • Human Ortholog
    TMEM123, transmembrane protein 123
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KCT3, PORIMIN, PORMIN
  • Links
    NCBI Gene ID: 114908
    neXtProt AC: NX_Q8N131
    UniProt: Q8N131

  • Chr Location
    11q22.2; chr11:102396325-102453044 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele exhibit no abnormal phenotype as revealed by limited studies of T cell activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71929 NCBI Gene Model | MGI Sequence Detail 30257 C57BL/6J ±  kb
transcript NR_152989 RefSeq | MGI Sequence Detail 2909 C57BL/6  
polypeptide Q91Z22 UniProt | EBI | MGI Sequence Detail 195 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 209
    cDNA 209

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory