Antxr2
Gene Detail

Symbol Name ID

Antxr2 anthrax toxin receptor 2 MGI:1919164

Synonyms

2310046B19Rik, cI-35, CMG2, CMG-2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

47.77 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:97884688-98030962 bp, - strand From NCBI annotation of GRCm38   146275 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:43236  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: anthrax toxin receptor
Gene Tree: Antxr2

Human homologs

Human Homolog		ANTXR2, anthrax toxin receptor 2
NCBI Gene ID		118429
neXtProt AC		NX_P58335
Human Synonyms		CMG2, CMG-2, HFS, ISH, JHF
Human Chr (Location)		4q21.21; chr4:80822771-80994477 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANTXR2

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Mice homozygous for null mutations display female infertility. Mice homozygous for one allele are highly resistant to Bacillus anthracis or anthrax toxin induced lethality. Young mice homozygous for a second allele display pregnancy-related premature death and failure of parturition.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	reproductive process
Component	integral to membrane, membrane
Function	metal ion binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) cDNA(50)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000029338 (Evidence)
Entrez Gene	71914 (Evidence)
UniGene	24842
DFCI	TC1575180, TC1768322
DoTS	DT.101236576, DT.91385848, DT.97361570
NIA Mouse Gene Index	U041026
Consensus CDS Project	CCDS39177.1
International Mouse Knockout Project Status	Antxr2

Sequences

Length	Strain/Species
genomic	71914	NCBI Gene Model | MGI Sequence Detail	146275	C57BL/6J
transcript	NM_133738	RefSeq | MGI Sequence Detail	3776	C57BL/6
polypeptide	Q6DFX2	UniProt | EBI | MGI Sequence Detail	487	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(950 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017360	Anthrax toxin receptor
InterPro	IPR008399	Anthrax toxin receptor, C-terminal
InterPro	IPR008400	Anthrax toxin receptor, extracellular
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000004069	anthrax toxin receptor 2

Graphical View of Protein Domain Structure

References

(Earliest) J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(35)

Other accession IDs

MGI:1930793