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Antxr2
Gene Detail
Symbol

Name
ID
Antxr2
anthrax toxin receptor 2
MGI:1919164
Synonyms
2310046B19Rik, cI-35, CMG2, CMG-2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
47.77 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:97882783-98031043 bp, - strand
From VEGA annotation of GRCm38

  148261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:43236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ANTXR2
Protein SuperFamily: anthrax toxin receptor
Gene Tree: Antxr2

Human
homologs
ANTXR2, anthrax toxin receptor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 118429
neXtProt AC: NX_P58335

Human Synonyms: CMG2, CMG-2, HFS, ISH, JHF

Human Chr (Location): 4q21.21; chr4:79901617-80073472 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ANTXR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations display female infertility. Mice homozygous for one allele are highly resistant to Bacillus anthracis or anthrax toxin induced lethality. Young mice homozygous for a second allele display pregnancy-related premature death and failure of parturition.
 
Phenotype Images(6)
Interactions
Antxr2 interacts with 450 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process reproductive process, toxin transport
Component cell surface, external side of plasma membrane, ...
Function metal ion binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase antxr2 ; ZFIN antxr2a    NEW 
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000053314 (Evidence)
Ensembl Gene Model ENSMUSG00000029338 (Evidence)
Entrez Gene 71914 (Evidence)
UniGene 24842
DFCI TC1575180, TC1768322
DoTS DT.101236576, DT.91385848, DT.97361570
NIA Mouse Gene Index U041026
Consensus CDS Project CCDS39177.1
International Mouse Phenotyping Consortium Status Antxr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053314 VEGA Gene Model | MGI Sequence Detail 148261 C57BL/6J ±  kb
transcript OTTMUST00000133151 VEGA | MGI Sequence Detail 2739 Not Applicable 
polypeptide OTTMUSP00000070874 VEGA | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1235 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1241)
Protein-related
information
ResourceIDDescription
InterPro IPR017360 Anthrax toxin receptor
InterPro IPR008399 Anthrax toxin receptor, C-terminal
InterPro IPR008400 Anthrax toxin receptor, extracellular
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000004069 anthrax toxin receptor 2
References
(Earliest) J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
(Latest) J:205421 Liu S, et al., Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013 Sep 5;501(7465):63-8
All references(37)
Other
accession IDs
MGI:1930793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory