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Antxr2 Gene Detail
Summary
  • Symbol
    Antxr2
  • Name
    anthrax toxin receptor 2
  • Synonyms
    2310046B19Rik, cI-35, CMG2, CMG-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919164
    NCBI Gene: 71914
  • Gene Overview
    MyGene.info: ANTXR2
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:97884688-98030962 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.77 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919164
protein coding gene Chr5:97882783-98031043 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029771
protein coding gene Chr5:99208023-99366600 (-)
A/J MGP_AJ_G0029737
protein coding gene Chr5:95550961-95685998 (-)
AKR/J MGP_AKRJ_G0029683
protein coding gene Chr5:98724546-98867562 (-)
BALB/cJ MGP_BALBcJ_G0029747
protein coding gene Chr5:96552078-96697037 (-)
C3H/HeJ MGP_C3HHeJ_G0029470
protein coding gene Chr5:99056699-99200970 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030202
protein coding gene Chr5:103371432-103530081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027437
protein coding gene Chr5:90873074-91005009 (-)
CAST/EiJ MGP_CASTEiJ_G0028881
protein coding gene Chr5:97671371-97823266 (-)
CBA/J MGP_CBAJ_G0029440
protein coding gene Chr5:106949755-107115978 (-)
DBA/2J MGP_DBA2J_G0029584
protein coding gene Chr5:95745285-95883948 (-)
FVB/NJ MGP_FVBNJ_G0029543
protein coding gene Chr5:94564831-94699960 (-)
LP/J MGP_LPJ_G0029672
protein coding gene Chr5:99836224-99983344 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029572
protein coding gene Chr5:112043540-112195915 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030235
protein coding gene Chr5:98161796-98303364 (-)
PWK/PhJ MGP_PWKPhJ_G0028599
protein coding gene Chr5:94153477-94292802 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028434
protein coding gene Chr5:95831181-95985497 (-)
WSB/EiJ MGP_WSBEiJ_G0028959
protein coding gene Chr5:98477433-98626329 (-)



Homology
more
  • Human Ortholog
    ANTXR2, ANTXR cell adhesion molecule 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ANTXR2, ANTXR cell adhesion molecule 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMG2, CMG-2, HFS, ISH, JHF
  • Links
    NCBI Gene ID: 118429
    neXtProt AC: NX_P58335
    UniProt: P58335

  • Chr Location
    4q21.21; chr4:79901617-80073472 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    3 involving Antxr2
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for null mutations display female infertility. Mice homozygous for one allele are highly resistant to Bacillus anthracis or anthrax toxin induced lethality. Young mice homozygous for a second allele display pregnancy-related premature death and failure of parturition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71914 NCBI Gene Model | MGI Sequence Detail 146275 C57BL/6J ±  kb
transcript NM_133738 RefSeq | MGI Sequence Detail 3831 C57BL/6  
polypeptide Q6DFX2 UniProt | EBI | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR017360 Anthrax toxin receptor
    IPR008399 Anthrax toxin receptor, C-terminal
    IPR008400 Anthrax toxin receptor, extracellular
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 52
    cDNA 52

    Microarray probesets 4
Other
Accession IDs
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MGI:1930793
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:234402 Liu S, et al., Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4079-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory