About   Help   FAQ
Antxr2
Gene Detail
 Symbol
Name
ID
Antxr2
anthrax toxin receptor 2
MGI:1919164
Synonyms 2310046B19Rik, cI-35, CMG2, CMG-2
Feature Type protein coding gene
Genetic Map
Chromosome 5
47.77 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:97884688-98030962 bp, - strand
From NCBI annotation of GRCm38

  146275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:43236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: anthrax toxin receptor
Gene Tree: Antxr2

Human
homologs
Human Homolog ANTXR2, anthrax toxin receptor 2
NCBI Gene ID 118429
neXtProt AC  NX_P58335
Human Synonyms  CMG2, CMG-2, HFS, ISH, JHF
Human Chr (Location)  4q21.21; chr4:79901617-80073472 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANTXR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations display female infertility. Mice homozygous for one allele are highly resistant to Bacillus anthracis or anthrax toxin induced lethality. Young mice homozygous for a second allele display pregnancy-related premature death and failure of parturition.
 
Phenotype Images(6)
Interactions
Antxr2 interacts with 451 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process reproductive process
Component integral component of membrane, membrane
Function metal ion binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029338 (Evidence)
Entrez Gene71914 (Evidence)
UniGene24842
DFCITC1575180, TC1768322
DoTSDT.101236576, DT.91385848, DT.97361570
NIA Mouse Gene IndexU041026
Consensus CDS ProjectCCDS39177.1
International Mouse Knockout Project StatusAntxr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 71914 NCBI Gene Model | MGI Sequence Detail 146275 C57BL/6J ±  kb
transcript NM_133738 RefSeq | MGI Sequence Detail 3776 C57BL/6 
polypeptide Q6DFX2 UniProt | EBI | MGI Sequence Detail 487 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(1230 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1236)
Protein-related
information
ResourceIDDescription
InterPro IPR017360 Anthrax toxin receptor
InterPro IPR008399 Anthrax toxin receptor, C-terminal
InterPro IPR008400 Anthrax toxin receptor, extracellular
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000004069 anthrax toxin receptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
(Latest) J:205421 Liu S, et al., Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013 Sep 5;501(7465):63-8
All references(36)
Other
accession IDs
MGI:1930793

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory