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Epn3 Gene Detail
Summary
  • Symbol
    Epn3
  • Name
    epsin 3
  • Synonyms
    2310022G12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919139
    NCBI Gene: 71889
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94489599-94499974 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919139
protein coding gene Chr11:94489599-94499974 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018958
protein coding gene Chr11:96585292-96595647 (-)
A/J MGP_AJ_G0018926
protein coding gene Chr11:92722337-92732757 (-)
AKR/J MGP_AKRJ_G0018896
protein coding gene Chr11:95607264-95617650 (-)
BALB/cJ MGP_BALBcJ_G0018899
protein coding gene Chr11:93172770-93183125 (-)
C3H/HeJ MGP_C3HHeJ_G0018713
protein coding gene Chr11:95690329-95701620 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019351
protein coding gene Chr11:99592666-99603041 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016982
protein coding gene Chr11:90216859-90227249 (-)
CAST/EiJ MGP_CASTEiJ_G0018268
protein coding gene Chr11:96407030-96419099 (-)
CBA/J MGP_CBAJ_G0018684
protein coding gene Chr11:103731532-103741958 (-)
DBA/2J MGP_DBA2J_G0018792
protein coding gene Chr11:92298616-92309032 (-)
FVB/NJ MGP_FVBNJ_G0018781
protein coding gene Chr11:91719566-91729947 (-)
LP/J MGP_LPJ_G0018862
protein coding gene Chr11:97129953-97141715 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018808
protein coding gene Chr11:103752454-103762853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019391
protein coding gene Chr11:95834610-95844985 (-)
PWK/PhJ MGP_PWKPhJ_G0018038
protein coding gene Chr11:93231605-93242384 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017828
protein coding gene Chr11:95496113-95506156 (-)
WSB/EiJ MGP_WSBEiJ_G0018317
protein coding gene Chr11:95715152-95725748 (-)



Homology
more
  • Human Ortholog
    EPN3, epsin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPN3, epsin 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55040
    neXtProt AC: NX_Q9H201
    UniProt: Q9H201

  • Chr Location
    17q21.33; chr17:50532687-50543750 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71889 NCBI Gene Model | MGI Sequence Detail 10376 C57BL/6J ±  kb
transcript NM_027984 RefSeq | MGI Sequence Detail 3884 C57BL/6  
polypeptide Q91W69 UniProt | EBI | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:241381 Mori J, et al., EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis. Neoplasia. 2017 Mar;19(3):185-195

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory