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Krt33a Gene Detail
Summary
  • Symbol
    Krt33a
  • Name
    keratin 33A
  • Synonyms
    2310015J09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919138
    NCBI Gene: 71888
  • Gene Overview
    MyGene.info: KRT33A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100011199-100016212 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.35 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919138
protein coding gene Chr11:100011195-100016212 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019134
protein coding gene Chr11:102747117-102761450 (-)
A/J MGP_AJ_G0019102
protein coding gene Chr11:98416727-98421299 (-)
AKR/J MGP_AKRJ_G0019071
protein coding gene Chr11:101457118-101463144 (-)
BALB/cJ MGP_BALBcJ_G0019076
protein coding gene Chr11:98933498-98939206 (-)
C3H/HeJ MGP_C3HHeJ_G0018885
protein coding gene Chr11:101652181-101657016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019525
protein coding gene Chr11:105906857-105913966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017152
protein coding gene Chr11:95870376-95875435 (-)
CAST/EiJ MGP_CASTEiJ_G0018439
protein coding gene Chr11:102629638-102638754 (-)
CBA/J MGP_CBAJ_G0018854
protein coding gene Chr11:110345534-110353000 (-)
DBA/2J MGP_DBA2J_G0018967
protein coding gene Chr11:97981778-97986789 (-)
FVB/NJ MGP_FVBNJ_G0018956
protein coding gene Chr11:97489858-97495142 (-)
LP/J MGP_LPJ_G0019036
protein coding gene Chr11:103275518-103285745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018987
protein coding gene Chr11:109973062-109979946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019563
protein coding gene Chr11:101830435-101838518 (-)
PWK/PhJ MGP_PWKPhJ_G0018205
protein coding gene Chr11:99019641-99025025 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017994
protein coding gene Chr11:101525155-101531594 (-)
WSB/EiJ MGP_WSBEiJ_G0018489
protein coding gene Chr11:101799788-101806134 (-)



Homology
more
  • Human Ortholog
    KRT31, keratin 31
  • Vertebrate Orthologs
    12
  • Human Ortholog
    KRT31, keratin 31
    Orthology source: HomoloGene
  • Synonyms
    Ha-1, HA1, hHa1, KRTHA1
  • Links
    NCBI Gene ID: 3881
    neXtProt AC: NX_Q15323
    UniProt: Q15323

  • Chr Location
    17q21.2; chr17:41393724-41397592 (-)  GRCh38.p7

  • Human Ortholog
    KRT33A, keratin 33A
    Orthology source: HGNC
  • Synonyms
    Ha-3I, HA3I, hHa3-I, K33A, Krt1-3, KRTHA3A
  • Links
    NCBI Gene ID: 3883
    neXtProt AC: NX_O76009
    UniProt: O76009

  • Chr Location
    17q21.2; chr17:41345704-41350812 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations of this gene cause the hair coat to appear either shiny, reflective and "polished" or greasy looking, disheveled and "spikey."
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71888 NCBI Gene Model | MGI Sequence Detail 5014 C57BL/6J ±  kb
transcript NM_027983 RefSeq | MGI Sequence Detail 1679 C57BL/6  
polypeptide Q8K0Y2 UniProt | EBI | MGI Sequence Detail 404 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR039008 Intermediate filament, rod domain
    IPR002957 Keratin, type I
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:239434 Fleger-Weckmann A, et al., Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol. 2016 Dec;56:42-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory