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Coq2 Gene Detail
Summary
  • Symbol
    Coq2
  • Name
    coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
  • Synonyms
    2310002F18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919133
    NCBI Gene: 71883
  • Gene Overview
    MyGene.info: COQ2
Location & Maps
more
  • Sequence Map
    Chr5:100654723-100675140 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20418 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    COQ2, coenzyme Q2, polyprenyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COQ2, coenzyme Q2, polyprenyltransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CL640, COQ10D1, MSA1, PHB:PPT
  • Links
    NCBI Gene ID: 27235
    neXtProt AC: NX_Q96H96

  • Chr Location
    4q21.23; chr4:83138601-83285089 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69192
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: COQ2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human COQ2 associations

Human Disease Mouse Models
       Coenzyme Q10 Deficiency, Primary, 1; COQ10D1   OMIM: 607426
Multiple System Atrophy 1, Susceptibility To; MSA1   OMIM: 146500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Coq2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026156 VEGA Gene Model | MGI Sequence Detail 20418 C57BL/6J ±  kb
transcript OTTMUST00000064609 VEGA | MGI Sequence Detail 1743 Not Applicable  
polypeptide OTTMUSP00000032111 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    263 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005751 4-hydroxybenzoate polyprenyltransferase, mitochondrial
  • EC
  • InterPro Domains
    IPR031103 4-hydroxybenzoate octaprenyltransferase
    IPR006370 4-hydroxybenzoate polyprenyltransferase
    IPR030470 UbiA prenyltransferase conserved site
    IPR000537 UbiA prenyltransferase family
Molecular
Reagents
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  • All nucleic 59
    cDNA 59

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:176132 O'Leary J, et al., Global analysis of gene expression in the developing brain of gtf2ird1 knockout mice. PLoS One. 2011;6(8):e23868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory