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Aox4 Gene Detail
Summary
  • Symbol
    Aox4
  • Name
    aldehyde oxidase 4
  • Synonyms
    2310003G12Rik, AOH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919122
    NCBI Gene: 71872
Location & Maps
more
  • Sequence Map
    Chr1:58210397-58268597 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58201 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.97 cM
  • Mapping Data
    4 experiments
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Aox4
  • Incidental Mutations
Mice homozygous for a null allele exhibit a slight decrease in prenatal survival and epidermal thickening that is exacerbated by UV treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026036 VEGA Gene Model | MGI Sequence Detail 58201 C57BL/6J ±  kb
transcript OTTMUST00000064268 VEGA | MGI Sequence Detail 4973 Not Applicable  
polypeptide OTTMUSP00000031888 VEGA | MGI Sequence Detail 1336 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    725 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR002888 [2Fe-2S]-binding
    IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
    IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
    IPR014313 Aldehyde oxidase
    IPR016208 Aldehyde oxidase/xanthine dehydrogenase
    IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
    IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
    IPR012675 Beta-grasp domain
    IPR005107 CO dehydrogenase flavoprotein, C-terminal
    IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
    IPR016166 FAD-binding, type 2
    IPR016167 FAD-binding, type 2, subdomain 1
    IPR002346 Molybdopterin dehydrogenase, FAD-binding
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:64699 Terao M, et al., Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. J Biol Chem. 2000 Sep 29;275(39):30690-700
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory