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Aox4
Gene Detail
 Symbol
Name
ID
Aox4
aldehyde oxidase 4
MGI:1919122
Synonyms 2310003G12Rik, AOH2
Feature Type protein coding gene
Genetic Map
Chromosome 1
28.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:58210397-58268597 bp, + strand
From VEGA annotation of GRCm38

  58201 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:70273  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: xanthine dehydrogenase
Gene Tree: Aox4

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit a slight decrease in prenatal survival and epidermal thickening that is exacerbated by UV treatment.
 
Interactions
Aox4 interacts with 159 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process oxidation-reduction process
Component cytoplasm
Function 2 iron, 2 sulfur cluster binding, aldehyde oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (8)    Tissues (2)    Images (6)
Theiler Stages: 23
Assay TypeResults
RNA in situ 8
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026036 (Evidence)
Ensembl Gene ModelENSMUSG00000038242 (Evidence)
Entrez Gene71872 (Evidence)
UniGene244525
DFCITC1583673, TC1631031
DoTSDT.101150135, DT.101711823, DT.40166627, DT.94138112
EC1.17.3.-, 1.2.3.1
Consensus CDS ProjectCCDS14970.1
International Mouse Knockout Project StatusAox4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026036 VEGA Gene Model | MGI Sequence Detail 58201 C57BL/6J ±  kb
transcript OTTMUST00000064268 VEGA | MGI Sequence Detail 4973 Not Applicable 
polypeptide OTTMUSP00000031888 VEGA | MGI Sequence Detail 1336 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(728 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002888 [2Fe-2S]-binding
InterPro IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
InterPro IPR001041 2Fe-2S ferredoxin-type domain
InterPro IPR014313 Aldehyde oxidase
InterPro IPR016208 Aldehyde oxidase/xanthine dehydrogenase
InterPro IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
InterPro IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
InterPro IPR012675 Beta-grasp domain
InterPro IPR005107 CO dehydrogenase flavoprotein, C-terminal
InterPro IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
InterPro IPR016166 FAD-binding, type 2
InterPro IPR016167 FAD-binding, type 2, subdomain 1
InterPro IPR002346 Molybdopterin dehydrogenase, FAD-binding
References (Earliest) J:64699 Terao M, et al., Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. J Biol Chem. 2000 Sep 29;275(39):30690-700
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory