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Aox4 Gene Detail
Summary
  • Symbol
    Aox4
  • Name
    aldehyde oxidase 4
  • Synonyms
    2310003G12Rik, AOH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919122
    NCBI Gene: 71872
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:58210397-58268597 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58201 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 28.97 cM
  • Mapping Data
    4 experiments
Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight decrease in prenatal survival and epidermal thickening that is exacerbated by UV treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026036 VEGA Gene Model | MGI Sequence Detail 58201 C57BL/6J ±  kb
    transcript OTTMUST00000064268 VEGA | MGI Sequence Detail 4973 Not Applicable  
    polypeptide OTTMUSP00000031888 VEGA | MGI Sequence Detail 1336 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      725 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR002888 [2Fe-2S]-binding
      IPR036884 [2Fe-2S]-binding domain superfamily
      IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
      IPR036010 2Fe-2S ferredoxin-like superfamily
      IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain
      IPR014313 Aldehyde oxidase
      IPR016208 Aldehyde oxidase/xanthine dehydrogenase
      IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
      IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
      IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
      IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
      IPR005107 CO dehydrogenase flavoprotein, C-terminal
      IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily
      IPR016166 FAD-binding domain, PCMH-type
      IPR036318 FAD-binding, type PCMH-like superfamily
      IPR002346 Molybdopterin dehydrogenase, FAD-binding
    Molecular
    Reagents
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    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:264374 Terao M, et al., Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity. Sci Rep. 2016 Jul 26;6:30343

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory