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Shcbp1l Gene Detail
Summary
  • Symbol
    Shcbp1l
  • Name
    Shc SH2-domain binding protein 1-like
  • Synonyms
    1700012A16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919086
    NCBI Gene: 71836
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153425162-153452574 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919086
protein coding gene Chr1:153425096-153452574 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016596
protein coding gene Chr1:158248840-158276227 (+)
A/J MGP_AJ_G0016578
protein coding gene Chr1:151870186-151898510 (+)
AKR/J MGP_AKRJ_G0016543
protein coding gene Chr1:156572763-156602512 (+)
BALB/cJ MGP_BALBcJ_G0016538
protein coding gene Chr1:152421324-152448808 (+)
C3H/HeJ MGP_C3HHeJ_G0016363
protein coding gene Chr1:156673029-156700440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016999
protein coding gene Chr1:163723813-163751253 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014708
protein coding gene Chr1:144158787-144190167 (+)
CAST/EiJ MGP_CASTEiJ_G0015942
protein coding gene Chr1:156186744-156215320 (+)
CBA/J MGP_CBAJ_G0016337
protein coding gene Chr1:169478021-169510302 (+)
DBA/2J MGP_DBA2J_G0016443
protein coding gene Chr1:150893678-150921116 (+)
FVB/NJ MGP_FVBNJ_G0016441
protein coding gene Chr1:149354411-149385386 (+)
LP/J MGP_LPJ_G0016514
protein coding gene Chr1:159373259-159401436 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016467
protein coding gene Chr1:177113867-177141327 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017035
protein coding gene Chr1:156346557-156373984 (+)
PWK/PhJ MGP_PWKPhJ_G0015728
protein coding gene Chr1:149929602-149957605 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015515
protein coding gene Chr1:155144939-155172272 (+)
WSB/EiJ MGP_WSBEiJ_G0016005
protein coding gene Chr1:156421637-156449032 (+)



Homology
more
  • Human Ortholog
    SHCBP1L, SHC binding and spindle associated 1 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SHCBP1L, SHC binding and spindle associated 1 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf14, GE36
  • Links
    NCBI Gene ID: 81626
    neXtProt AC: NX_Q9BZQ2
    UniProt: Q9BZQ2

  • Chr Location
    1q25.3; chr1:182899865-182953418 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Shcbp1l
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit reduced male fertility with reduced sperm, increased male germ cell apoptosis and spindle instability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042708 Ensembl Gene Model | MGI Sequence Detail 27413 C57BL/6J ±  kb
transcript ENSMUST00000042373 Ensembl | MGI Sequence Detail 2092 Not Applicable  
polypeptide ENSMUSP00000036347 Ensembl | MGI Sequence Detail 639 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228105 Liu M, et al., SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. Mol Hum Reprod. 2014 Jun;20(6):463-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory