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Shcbp1l Gene Detail
Summary
  • Symbol
    Shcbp1l
  • Name
    Shc SH2-domain binding protein 1-like
  • Synonyms
    1700012A16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919086
    NCBI Gene: 71836
Location & Maps
more
  • Sequence Map
    Chr1:153425162-153452574 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27413 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.36 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SHCBP1L, SHC binding and spindle associated 1 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SHCBP1L, SHC binding and spindle associated 1 like
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C1orf14, GE36
  • Links
    NCBI Gene ID: 81626
    neXtProt AC: NX_Q9BZQ2

  • Chr Location
    1q25.3; chr1:182899865-182953418 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Shcbp1l
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit reduced male fertility with reduced sperm, increased male germ cell apoptosis and spindle instability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022957 VEGA Gene Model | MGI Sequence Detail 27413 C57BL/6J ±  kb
transcript OTTMUST00000055224 VEGA | MGI Sequence Detail 2092 Not Applicable  
polypeptide OTTMUSP00000026419 VEGA | MGI Sequence Detail 639 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    170 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031404 SHC SH2 domain-binding protein 1-like protein
  • InterPro Domains
    IPR006633 Carbohydrate-binding/sugar hydrolysis domain
    IPR006626 Parallel beta-helix repeat
    IPR012334 Pectin lyase fold
    IPR011050 Pectin lyase fold/virulence factor
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228105 Liu M, et al., SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis. Mol Hum Reprod. 2014 Jun;20(6):463-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory