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Csl Gene Detail
Summary
  • Symbol
    Csl
  • Name
    citrate synthase like
  • Synonyms
    1700007H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919082
    NCBI Gene: 71832
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:99593568-99595520 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 51.20 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919082
protein coding gene Chr10:99593567-99595520 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017688
protein coding gene Chr10:101601827-101603780 (-)
A/J MGP_AJ_G0017667
protein coding gene Chr10:97910523-97912476 (-)
AKR/J MGP_AKRJ_G0017627
protein coding gene Chr10:100709701-100711657 (-)
BALB/cJ MGP_BALBcJ_G0017631
protein coding gene Chr10:98219512-98221465 (-)
C3H/HeJ MGP_C3HHeJ_G0017454
protein coding gene Chr10:100737213-100739204 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018087
protein coding gene Chr10:105130519-105132472 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015767
protein coding gene Chr10:93321703-93323663 (-)
CAST/EiJ MGP_CASTEiJ_G0017017
protein coding gene Chr10:100824377-100827450 (-)
CBA/J MGP_CBAJ_G0017423
protein coding gene Chr10:109204098-109206058 (-)
DBA/2J MGP_DBA2J_G0017529
protein coding gene Chr10:96997480-96999433 (-)
FVB/NJ MGP_FVBNJ_G0017522
protein coding gene Chr10:96202400-96204553 (-)
LP/J MGP_LPJ_G0017603
protein coding gene Chr10:102189378-102191331 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017552
protein coding gene Chr10:110466392-110468342 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018125
protein coding gene Chr10:100675137-100677090 (-)
PWK/PhJ MGP_PWKPhJ_G0016799
protein coding gene Chr10:97126287-97128356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016588
protein coding gene Chr10:99546875-99548834 (-)
WSB/EiJ MGP_WSBEiJ_G0017077
protein coding gene Chr10:100642372-100644317 (-)



Homology
more
  • Human Ortholog
    CS, citrate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CS, citrate synthase
  • Links
    NCBI Gene ID: 1431
    neXtProt AC: NX_O75390
    UniProt: O75390

  • Chr Location
    12q13.3; chr12:56271699-56300391 (-)  GRCh38.p7

  • Alliance of Genome Resources
    Csl stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: CS
  • Gene Tree
    Csl
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are initially fertile but show an age-dependent decline in fertility and a delay in the first spike of Ca2+ oscillation during egg activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046934 Ensembl Gene Model | MGI Sequence Detail 1953 C57BL/6J ±  kb
    transcript ENSMUST00000056085 Ensembl | MGI Sequence Detail 1953 Not Applicable  
    polypeptide ENSMUSP00000052373 Ensembl | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR002020 Citrate synthase
      IPR019810 Citrate synthase active site
      IPR010109 Citrate synthase, eukaryotic-type
      IPR016142 Citrate synthase-like, large alpha subdomain
      IPR016143 Citrate synthase-like, small alpha subdomain
      IPR036969 Citrate synthase superfamily
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:299762 Kang W, et al., Neuronal expression of Ca(2+) oscillation initiator is linked to rapid neonatal growth in mice. MicroPubl Biol. 2020 Nov 12;2020

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/21/2021
    MGI 6.17
    The Jackson Laboratory