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Pdilt
Gene Detail
Symbol

Name
ID
Pdilt
protein disulfide isomerase-like, testis expressed
MGI:1919080
Synonyms
1700007B13Rik, PDILT
Feature Type
protein coding gene
Genetic Map
Chromosome 7
63.90 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:119486587-119523482 bp, - strand
From VEGA annotation of GRCm38

  36896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: protein disulfide-isomerase
Gene Tree: Pdilt

Human
homologs
Human Homolog PDILT, protein disulfide isomerase-like, testis expressed
NCBI Gene ID 204474
neXtProt AC  NX_Q8N807
Human Synonyms  PDIA7
Human Chr (Location)  16p12.3; chr16:20359170-20404742 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit male infertility and abnormal sperm physiology.
 
Interactions
Pdilt interacts with 60 markers (Mir16-2, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell differentiation, cell migration, ...
Component endoplasmic reticulum
Function isomerase activity, peptidyl-proline 4-dioxygenase activity, ...
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043386 (Evidence)
Ensembl Gene ModelENSMUSG00000030968 (Evidence)
Entrez Gene71830 (Evidence)
UniGene84631
DFCITC1590165
DoTSDT.55210158
NIA Mouse Gene IndexU029183
Consensus CDS ProjectCCDS52378.1
International Mouse Knockout Project StatusPdilt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043386 VEGA Gene Model | MGI Sequence Detail 36896 C57BL/6J ±  kb
transcript OTTMUST00000113832 VEGA | MGI Sequence Detail 2139 Not Applicable 
polypeptide OTTMUSP00000063592 VEGA | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(261 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000012503 protein disulfide-isomerase-like protein of the testis
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182133 Tokuhiro K, et al., Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3850-5
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory