Ints12 MGI Mouse Gene Detail - MGI:1919043 - integrator complex subunit 12

Symbol

Ints12
Name

integrator complex subunit 12
Synonyms

1110020M19Rik, 2810027J24Rik, 4930529N21Rik, A230056J18Rik, Phf22

Feature Type

protein coding gene
IDs

MGI:1919043
NCBI Gene: 71793
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:132797616-132816749 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 61.56 cM, cytoband H2
Mapping Data

3 experiments

SNPs within 2kb

653 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919043	protein coding gene	Chr3:132797601-132816749 (+)
129S1/SvImJ	ENSMUSG00200003629	protein coding gene	Chr3:129573256-129592363 (+)
A/J	ENSMUSG00195008164	protein coding gene	Chr3:129679053-129698201 (+)
AKR/J	ENSMUSG00220022004	protein coding gene	Chr3:128119467-128138615 (+)
BALB/cJ	ENSMUSG00180003533	protein coding gene	Chr3:129607937-129627086 (+)
C3H/HeJ	ENSMUSG00175013286	protein coding gene	Chr3:129181682-129200834 (+)
C57BL/6NJ	ENSMUSG00215017976	protein coding gene	Chr3:129953266-129972414 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025648	protein coding gene	Chr3:126517402-126536701 (+)
CAST/EiJ	ENSTCUG00005003455	protein coding gene	Chr3:130292090-130311193 (+)
CBA/J	ENSMUSG00210003963	protein coding gene	Chr3:129799456-129818604 (+)
DBA/2J	ENSMUSG00185025847	protein coding gene	Chr3:130417178-130436285 (+)
FVB/NJ	ENSMUSG00205021716	protein coding gene	Chr3:128738435-128757585 (+)
JF1/MsJ	ENSUMUG00000014017	protein coding gene	Chr3:129169561-129188731 (+)
LP/J	ENSMUSG00230002713	protein coding gene	Chr3:132391698-132410805 (+)
NOD/ShiLtJ	ENSMUSG00190001191	protein coding gene	Chr3:130796085-130815233 (+)
NZO/HlLtJ	ENSMUSG00225004648	protein coding gene	Chr3:134832517-134851651 (+)
PWK/PhJ	ENSLUMG00010015017	protein coding gene	Chr3:129155923-129175002 (+)
SPRET/EiJ	ENSMSPG00010012758	protein coding gene	Chr3:130202470-130221211 (+)
WSB/EiJ	ENSIUOG00005016601	protein coding gene	Chr3:129943005-129962118 (+)

Human Ortholog

INTS12, integrator complex subunit 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INTS12, integrator complex subunit 12
Synonyms

INT12, PHF22, SBBI22
Links

HGNC:25067

NCBI Gene ID: 57117

UniProt: Q96CB8
Chr Location

4q24; chr4:105682016-105895986 (-) GRCh38

MGI Vertebrate Homology

Ints12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INTS12
Gene Tree

Ints12

less

References

1 with disease annotations

less

Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Ints12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

28
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

701
Tissues

92
cDNA Data

54
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ints12

ZFIN ints12

less

All Sequences

45
RefSeq

2
UniProt

1
CCDS

CCDS17848.1

Ensembl

ENSMUSG00000028016 (Evidence)
NCBI Gene

71793

			Length	Strain/Species	Flank
genomic	71793	NCBI Gene Model \| MGI Sequence Detail	19134	C57BL/6J	± kb
transcript	NM_027927	RefSeq \| MGI Sequence Detail	3099	C57BL/6
polypeptide	Q9D168	UniProt \| EBI \| MGI Sequence Detail	461	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000009068 integrator complex subunit 12

(term hierarchy)
PDB

1WEV
InterPro Domains

IPR039054 Int12, PHD finger

IPR051776 Integrator complex subunit 12

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type
GlyGen

Q9D168 3 sites, 2 N-linked glycans (2 sites)

less

All nucleic 55

cDNA 54

Primer pair 1

Microarray probesets 5

less

MGI:1919937, MGI:1922431, MGI:2139786, MGI:2444032

Summaries

All 52

Developmental Gene Expression 4

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ints12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31768	Chr3:132797588-132797603 (+)	-20 bp
Tssr31769	Chr3:132797605-132797634 (+)	4 bp
Tssr31770	Chr3:132797647-132797668 (+)	42 bp
Tssr31771	Chr3:132797684-132797714 (+)	83 bp
Tssr31772	Chr3:132798331-132798372 (+)	736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24