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Isyna1 Gene Detail
Summary
  • Symbol
    Isyna1
  • Name
    myo-inositol 1-phosphate synthase A1
  • Synonyms
    1300017C10Rik, inositol-3-phosphate synthase 1, myo-inositol 1-phosphate synthase A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919030
    NCBI Gene: 71780
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71047131-71049940 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919030
protein coding gene Chr8:71047023-71049940 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033713
protein coding gene Chr8:70870114-70872922 (+)
A/J MGP_AJ_G0033696
protein coding gene Chr8:67993695-67996502 (+)
AKR/J MGP_AKRJ_G0033621
protein coding gene Chr8:69926311-69929101 (+)
BALB/cJ MGP_BALBcJ_G0033692
protein coding gene Chr8:68226488-68229296 (+)
C3H/HeJ MGP_C3HHeJ_G0033402
protein coding gene Chr8:70576332-70579140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034209
protein coding gene Chr8:73550761-73553568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031153
protein coding gene Chr8:62810365-62813134 (+)
CAST/EiJ MGP_CASTEiJ_G0032727
protein coding gene Chr8:70066262-70069051 (+)
CBA/J MGP_CBAJ_G0033380
protein coding gene Chr8:76186523-76189331 (+)
DBA/2J MGP_DBA2J_G0033534
protein coding gene Chr8:67709122-67711930 (+)
FVB/NJ MGP_FVBNJ_G0033475
protein coding gene Chr8:66835918-66838726 (+)
LP/J MGP_LPJ_G0033621
protein coding gene Chr8:70898488-70901296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033518
protein coding gene Chr8:78854357-78857164 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034227
protein coding gene Chr8:70112407-70115215 (+)
PWK/PhJ MGP_PWKPhJ_G0032435
protein coding gene Chr8:67009950-67012757 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032271
protein coding gene Chr8:69079229-69082042 (+)
WSB/EiJ MGP_WSBEiJ_G0032842
protein coding gene Chr8:70472656-70475446 (+)



Homology
more
  • Human Ortholog
    ISYNA1, inositol-3-phosphate synthase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISYNA1, inositol-3-phosphate synthase 1
  • Synonyms
    INO1, INOS, IPS, IPS 1, IPS-1
  • Links
    NCBI Gene ID: 51477
    neXtProt AC: NX_Q9NPH2
    UniProt: Q9NPH2

  • Chr Location
    19p13.11; chr19:18434388-18438167 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71780 NCBI Gene Model | MGI Sequence Detail 2810 C57BL/6J ±  kb
    transcript NM_023627 RefSeq | MGI Sequence Detail 1850 Not Specified  
    polypeptide Q9JHU9 UniProt | EBI | MGI Sequence Detail 557 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 185
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142685
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory