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March8 Gene Detail
Summary
  • Symbol
    March8
  • Name
    membrane-associated ring finger (C3HC4) 8
  • Synonyms
    1300017E09Rik, Mir
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919029
    NCBI Gene: 71779
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:116338024-116409540 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.78 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919029
protein coding gene Chr6:116337916-116409540 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031166
protein coding gene Chr6:119002704-119083008 (+)
A/J MGP_AJ_G0031136
protein coding gene Chr6:114439811-114510633 (+)
AKR/J MGP_AKRJ_G0031066
protein coding gene Chr6:117494812-117568431 (+)
BALB/cJ MGP_BALBcJ_G0031146
protein coding gene Chr6:114244761-114320898 (+)
C3H/HeJ MGP_C3HHeJ_G0030562
protein coding gene Chr6:66720672-66793303 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031605
protein coding gene Chr6:122064092-122151798 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028769
protein coding gene Chr6:111441219-111510292 (+)
CAST/EiJ MGP_CASTEiJ_G0030253
protein coding gene Chr6:117892755-117966290 (+)
CBA/J MGP_CBAJ_G0030832
protein coding gene Chr6:126838832-126924297 (+)
DBA/2J MGP_DBA2J_G0030986
protein coding gene Chr6:113353443-113425140 (+)
FVB/NJ MGP_FVBNJ_G0030939
protein coding gene Chr6:112544774-112620840 (+)
LP/J MGP_LPJ_G0031065
protein coding gene Chr6:119012008-119090840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030974
protein coding gene Chr6:130982457-131068221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031633
protein coding gene Chr6:117540019-117613324 (+)
PWK/PhJ MGP_PWKPhJ_G0029969
protein coding gene Chr6:112372946-112443515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029797
protein coding gene Chr6:116280257-116356437 (+)
WSB/EiJ MGP_WSBEiJ_G0030337
protein coding gene Chr6:117808298-117884916 (+)



Homology
more
  • Human Ortholog
    MARCHF8, membrane associated ring-CH-type finger 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MARCHF8, membrane associated ring-CH-type finger 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c-MIR, CMIR, MARCH8, MARCH-VIII, MIR, RNF178
  • Links
    NCBI Gene ID: 220972
    neXtProt AC: NX_Q5T0T0
    UniProt: Q5T0T0

  • Chr Location
    10q11.21-q11.22; chr10:45454585-45594907 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Mice homozygous for a knock-out allele exhibit a normal CD4+ T cell compartment in the thymus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025702 Ensembl Gene Model | MGI Sequence Detail 71517 C57BL/6J ±  kb
transcript ENSMUST00000123405 Ensembl | MGI Sequence Detail 2102 Not Applicable  
polypeptide ENSMUSP00000144936 Ensembl | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 147
    cDNA 147

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:267025 Jung H, et al., Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nat Neurosci. 2018 Sep;21(9):1218-1228

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory