Ap2b1
Gene Detail

Symbol Name ID

Ap2b1 adaptor-related protein complex 2, beta 1 subunit MGI:1919020

Synonyms

1300012O03Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

50.30 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:83299024-83405035 bp, + strand From VEGA annotation of GRCm38   106012 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adaptor protein complex, beta subunit
Gene Tree: Ap2b1

Human homologs

Human Homolog		AP2B1, adaptor-related protein complex 2, beta 1 subunit
NCBI Gene ID		163
neXtProt AC		NX_P63010
Human Synonyms		ADTB2, AP105B, AP2-BETA, CLAPB1
Human Chr (Location)		17q11.2-q12; chr17:33914282-34053436 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(61) : Targeted(3) Gene trapped(56) Transgenic(2)
 

Mice homozygous for a transgenic gene disruption exhibit cleft palate.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	clathrin coat assembly, intracellular protein transport, ...
Component	clathrin adaptor complex, clathrin coat, ...
Function	clathrin binding, protein complex binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (133)    Tissues (132)    Images (30)
Theiler Stages: 17, 19, 22, 23, 28

Assay Type	Results
RNA in situ	120
RT-PCR	13

cDNA source data(219)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(222) cDNA(219) Primer pair(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000000915 (Evidence)
Ensembl Gene Model	ENSMUSG00000035152 (Evidence)
Entrez Gene	71770 (Evidence)
UniGene	39053
DFCI	TC1575319, TC1588868, TC1600708, TC1674769
DoTS	DT.101272092, DT.101382500, DT.489733, DT.87036556, DT.91574931
NIA Mouse Gene Index	U013085
Consensus CDS Project	CCDS25161.1, CCDS25162.1
International Mouse Knockout Project Status	Ap2b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000915	VEGA Gene Model | MGI Sequence Detail	106012	C57BL/6J
transcript	OTTMUST00000001780	VEGA | MGI Sequence Detail	5625	Not Applicable
polypeptide	OTTMUSP00000000851	VEGA | MGI Sequence Detail	951	Not Applicable

All sequences(62) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(449 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016342	AP-1, 2,4 complex subunit beta
InterPro	IPR026739	AP complex subunit beta
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR012295	Beta2-adaptin/TBP, C-terminal domain
InterPro	IPR015151	Beta-adaptin appendage, C-terminal subdomain
InterPro	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro	IPR013037	Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
InterPro	IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro	IPR009028	Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro	IPR013041	Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology	PR:000004101	AP-2 complex subunit beta-1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)

Other accession IDs

MGI:2144265