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Ap2b1 Gene Detail
Summary
  • Symbol
    Ap2b1
  • Name
    adaptor-related protein complex 2, beta 1 subunit
  • Synonyms
    1300012O03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919020
    NCBI Gene: 71770
  • Gene Overview
    MyGene.info: AP2B1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83299024-83405035 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM, cytoband B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    606 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919020
protein coding gene Chr11:83298719-83405035 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018845
protein coding gene Chr11:84618640-84726242 (+)
A/J MGP_AJ_G0018812
protein coding gene Chr11:81407269-81515062 (+)
AKR/J MGP_AKRJ_G0018782
protein coding gene Chr11:83828064-83940462 (+)
BALB/cJ MGP_BALBcJ_G0018785
protein coding gene Chr11:81817942-81926482 (+)
C3H/HeJ MGP_C3HHeJ_G0018599
protein coding gene Chr11:83881162-84000280 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019237
protein coding gene Chr11:87216209-87325546 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016871
protein coding gene Chr11:78534157-78641631 (+)
CAST/EiJ MGP_CASTEiJ_G0018154
protein coding gene Chr11:84468411-84576633 (+)
CBA/J MGP_CBAJ_G0018570
protein coding gene Chr11:90992790-91099264 (+)
DBA/2J MGP_DBA2J_G0018678
protein coding gene Chr11:81004883-81111471 (+)
FVB/NJ MGP_FVBNJ_G0018667
protein coding gene Chr11:80486243-80594189 (+)
LP/J MGP_LPJ_G0018748
protein coding gene Chr11:85177334-85292203 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018694
protein coding gene Chr11:91156035-91267761 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019277
protein coding gene Chr11:84092175-84209008 (+)
PWK/PhJ MGP_PWKPhJ_G0017923
protein coding gene Chr11:81764097-81871011 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017715
protein coding gene Chr11:83640357-83748250 (+)
WSB/EiJ MGP_WSBEiJ_G0018205
protein coding gene Chr11:83965352-84074026 (+)



Homology
more
  • Human Ortholog
    AP2B1, adaptor related protein complex 2 subunit beta 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    AP2B1, adaptor related protein complex 2 subunit beta 1
    Orthology source: HGNC
  • Synonyms
    ADTB2, AP105B, AP2-BETA, CLAPB1
  • Links
    NCBI Gene ID: 163
    neXtProt AC: NX_P63010
    UniProt: P63010

  • Chr Location
    17q12; chr17:35586899-35726417 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    20 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035152 Ensembl Gene Model | MGI Sequence Detail 106012 C57BL/6J ±  kb
    transcript ENSMUST00000018875 Ensembl | MGI Sequence Detail 5625 Not Applicable  
    polypeptide ENSMUSP00000018875 Ensembl | MGI Sequence Detail 951 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000004101 AP-2 complex subunit beta
    • InterPro Domains
      IPR016342 AP-1/2/4 complex subunit beta
      IPR026739 AP complex subunit beta
      IPR000225 Armadillo
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR015151 Beta-adaptin appendage, C-terminal subdomain
      IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
      IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamily
      IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
      IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
      IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
      IPR012295 TBP domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 221
      cDNA 217
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144265
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:255150 Piccini A, et al., APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Cell Rep. 2017 Dec 19;21(12):3596-3611

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory