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Ap2b1
Gene Detail
 Symbol
Name
ID
Ap2b1
adaptor-related protein complex 2, beta 1 subunit
MGI:1919020
Synonyms 1300012O03Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
50.30 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:83299024-83405035 bp, + strand
From VEGA annotation of GRCm38

  106012 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137384  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: adaptor protein complex, beta subunit
Gene Tree: Ap2b1

Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Chemically induced (ENU)(1) Gene trapped(56) Targeted(3) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transgenic gene disruption exhibit cleft palate.
 
Phenotype Images(20)
Interactions
Ap2b1 interacts with 303 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process endocytosis, intracellular protein transport, ...
Component clathrin adaptor complex, coated pit, ...
Function clathrin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (133)    Tissues (132)    Images (30)
Theiler Stages: 17, 19, 22, 23, 28
Assay TypeResults
RNA in situ 120
RT-PCR 13
cDNA source data(216)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(219) cDNA(216) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000915 (Evidence)
Ensembl Gene ModelENSMUSG00000035152 (Evidence)
Entrez Gene71770 (Evidence)
UniGene39053
DFCITC1575319, TC1588868, TC1600708, TC1674769
DoTSDT.101272092, DT.101382500, DT.489733, DT.87036556, DT.91574931
NIA Mouse Gene IndexU013085
Consensus CDS ProjectCCDS25161.1, CCDS25162.1
International Mouse Knockout Project StatusAp2b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000915 VEGA Gene Model | MGI Sequence Detail 106012 C57BL/6J ±  kb
transcript OTTMUST00000001780 VEGA | MGI Sequence Detail 5625 Not Applicable 
polypeptide OTTMUSP00000000851 VEGA | MGI Sequence Detail 951 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(611 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016342 AP-1, 2,4 complex subunit beta
InterPro IPR026739 AP complex subunit beta
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR012295 Beta2-adaptin/TBP, C-terminal domain
InterPro IPR015151 Beta-adaptin appendage, C-terminal subdomain
InterPro IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
InterPro IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
InterPro IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
InterPro IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
InterPro IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Protein Ontology PR:000004101 AP-2 complex subunit beta
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(47)
Other
accession IDs
MGI:2144265

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory