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Ap2b1 Gene Detail
Summary
  • Symbol
    Ap2b1
  • Name
    adaptor-related protein complex 2, beta 1 subunit
  • Synonyms
    1300012O03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919020
    NCBI Gene: 71770
  • Gene Overview
    MyGene.info: AP2B1
Location & Maps
more
  • Sequence Map
    Chr11:83299024-83405035 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106012 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM, cytoband B5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AP2B1, adaptor related protein complex 2 beta 1 subunit
  • Vertebrate Orthologs
    2
  • Human Ortholog
    AP2B1, adaptor related protein complex 2 beta 1 subunit
    Orthology source: HGNC
  • Synonyms
    ADTB2, AP105B, AP2-BETA, CLAPB1
  • Links
    NCBI Gene ID: 163
    neXtProt AC: NX_P63010

  • Chr Location
    17q12; chr17:35586899-35726417 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    56
  • Targeted
    4
  • Transgenic
    2
  • Genomic Mutations
    2 involving Ap2b1
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000915 VEGA Gene Model | MGI Sequence Detail 106012 C57BL/6J ±  kb
transcript OTTMUST00000001780 VEGA | MGI Sequence Detail 5625 Not Applicable  
polypeptide OTTMUSP00000000851 VEGA | MGI Sequence Detail 951 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    606 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004101 AP-2 complex subunit beta
  • InterPro Domains
    IPR016342 AP-1, 2,4 complex subunit beta
    IPR026739 AP complex subunit beta
    IPR000225 Armadillo
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR012295 Beta2-adaptin/TBP, C-terminal domain
    IPR015151 Beta-adaptin appendage, C-terminal subdomain
    IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
    IPR013037 Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
    IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
    IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
    IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
Molecular
Reagents
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  • All nucleic 219
    cDNA 216
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
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MGI:2144265
References
more
  • Summaries
    All 46
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory