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Tysnd1 Gene Detail
Summary
  • Symbol
    Tysnd1
  • Name
    trypsin domain containing 1
  • Synonyms
    1300019N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919017
    NCBI Gene: 71767
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:61695514-61702773 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.26 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919017
protein coding gene Chr10:61695498-61702773 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017286
protein coding gene Chr10:61056939-61065693 (+)
A/J MGP_AJ_G0017264
protein coding gene Chr10:59223936-59231198 (+)
AKR/J MGP_AKRJ_G0017224
protein coding gene Chr10:60768993-60776257 (+)
BALB/cJ MGP_BALBcJ_G0017224
protein coding gene Chr10:59299707-59306908 (+)
C3H/HeJ MGP_C3HHeJ_G0017047
protein coding gene Chr10:60671554-60678931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017682
protein coding gene Chr10:63242765-63253395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015373
protein coding gene Chr10:56201664-56209073 (+)
CAST/EiJ MGP_CASTEiJ_G0016618
protein coding gene Chr10:60690606-60700628 (+)
CBA/J MGP_CBAJ_G0017019
protein coding gene Chr10:65605986-65613196 (+)
DBA/2J MGP_DBA2J_G0017124
protein coding gene Chr10:58495184-58502355 (+)
FVB/NJ MGP_FVBNJ_G0017118
protein coding gene Chr10:57746847-57754085 (+)
LP/J MGP_LPJ_G0017199
protein coding gene Chr10:61455737-61464168 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017146
protein coding gene Chr10:67902778-67911052 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017720
protein coding gene Chr10:60594941-60603364 (+)
PWK/PhJ MGP_PWKPhJ_G0016401
protein coding gene Chr10:58342383-58349814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016184
protein coding gene Chr10:59952405-59962414 (+)
WSB/EiJ MGP_WSBEiJ_G0016682
protein coding gene Chr10:60509699-60518031 (+)



Homology
more
  • Human Ortholog
    TYSND1, trypsin domain containing 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TYSND1, trypsin domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NET41
  • Links
    NCBI Gene ID: 219743
    neXtProt AC: NX_Q2T9J0
    UniProt: Q2T9J0

  • Chr Location
    10q22.1; chr10:70137981-70146740 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Tysnd1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit male infertility with globozoospermia, hypoactivity, absence acrosomal cap, indicators of liver damage, abnormal hepatocyte peroxisomes and autophagosomes and enlarged, beige livers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020087 Ensembl Gene Model | MGI Sequence Detail 7260 C57BL/6J ±  kb
transcript ENSMUST00000020284 Ensembl | MGI Sequence Detail 2286 Not Applicable  
polypeptide ENSMUSP00000020284 Ensembl | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    cDNA 58

    Microarray probesets 7
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:223054 Mizuno Y, et al., Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 2013;9(2):e1003286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory