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Tspan33 Gene Detail
Summary
  • Symbol
    Tspan33
  • Name
    tetraspanin 33
  • Synonyms
    1300010A20Rik, Pen, Penumbra
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919012
    NCBI Gene: 232670
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29694222-29718559 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919012
protein coding gene Chr6:29694214-29718559 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030529
protein coding gene Chr6:27514555-27539665 (+)
A/J MGP_AJ_G0030502
protein coding gene Chr6:26344104-26369534 (+)
AKR/J MGP_AKRJ_G0030429
protein coding gene Chr6:27211588-27235837 (+)
BALB/cJ MGP_BALBcJ_G0030512
protein coding gene Chr6:26507487-26533002 (+)
C3H/HeJ MGP_C3HHeJ_G0030225
protein coding gene Chr6:27220463-27244960 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030966
protein coding gene Chr6:28295454-28321008 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028177
protein coding gene Chr6:24550459-24574030 (+)
CAST/EiJ MGP_CASTEiJ_G0029627
protein coding gene Chr6:27020161-27044832 (+)
CBA/J MGP_CBAJ_G0030203
protein coding gene Chr6:29366763-29396247 (+)
DBA/2J MGP_DBA2J_G0030347
protein coding gene Chr6:26284828-26308894 (+)
FVB/NJ MGP_FVBNJ_G0030301
protein coding gene Chr6:26042154-26066583 (+)
LP/J MGP_LPJ_G0030434
protein coding gene Chr6:27642376-27668149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030337
protein coding gene Chr6:31860825-31885748 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030996
protein coding gene Chr6:27088802-27115383 (+)
PWK/PhJ MGP_PWKPhJ_G0029341
protein coding gene Chr6:25833356-25858099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029177
protein coding gene Chr6:26816818-26844484 (+)
WSB/EiJ MGP_WSBEiJ_G0029703
protein coding gene Chr6:27061475-27086543 (+)



Homology
more
  • Human Ortholog
    TSPAN33, tetraspanin 33
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TSPAN33, tetraspanin 33
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PEN, PEN., TSPAN-33
  • Links
    NCBI Gene ID: 340348
    neXtProt AC: NX_Q86UF1
    UniProt: Q86UF1

  • Chr Location
    7q32.1; chr7:129144716-129169694 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display anemia and partial penetrance of red blood cell abnormalities, splenomegaly, monocytosis, thrombocytopenia, reticulocytosis, and extramedullary hematopoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001763 Ensembl Gene Model | MGI Sequence Detail 24338 C57BL/6J ±  kb
    transcript ENSMUST00000046750 Ensembl | MGI Sequence Detail 1994 Not Applicable  
    polypeptide ENSMUSP00000045282 Ensembl | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144063
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:209476 Haining EJ, et al., The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J Biol Chem. 2012 Nov 16;287(47):39753-65

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory