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Tspan33
Gene Detail
Symbol

Name
ID
Tspan33
tetraspanin 33
MGI:1919012
Synonyms
1300010A20Rik, Pen, Penumbra
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:29694222-29718559 bp, + strand
From VEGA annotation of GRCm38

  24338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8213  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TSPAN33
Protein SuperFamily: tetraspanin
Gene Tree: Tspan33

Human
homologs
TSPAN33, tetraspanin 33
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 340348
neXtProt AC: NX_Q86UF1

Human Synonyms: PEN, PEN., TSPAN-33

Human Chr (Location): 7q32.1; chr7:129144716-129169694 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display anemia and partial penetrance of red blood cell abnormalities, splenomegaly, monocytosis, thrombocytopenia, reticulocytosis, and extramedullary hematopoiesis.
 
Interactions
Tspan33 interacts with 158 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process establishment of protein localization to plasma membrane, protein maturation
Component cell surface, integral component of membrane, ...
Function enzyme binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (4)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tspan33    NEW 
Molecular
reagents
All nucleic(29) cDNA(29)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000013447 (Evidence)
Ensembl Gene Model ENSMUSG00000001763 (Evidence)
Entrez Gene 232670 (Evidence)
UniGene 225289
DFCI TC1581253
DoTS DT.94143336, DT.531285
NIA Mouse Gene Index U006618
Consensus CDS Project CCDS19964.1
International Mouse Phenotyping Consortium Status Tspan33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013447 VEGA Gene Model | MGI Sequence Detail 24338 C57BL/6J ±  kb
transcript OTTMUST00000032500 VEGA | MGI Sequence Detail 1994 Not Applicable 
polypeptide OTTMUSP00000014436 VEGA | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000016749 tetraspanin-33
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209476 Haining EJ, et al., The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. J Biol Chem. 2012 Nov 16;287(47):39753-65
All references(31)
Other
accession IDs
MGI:2144063

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory