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Vwa8 Gene Detail
Summary
  • Symbol
    Vwa8
  • Name
    von Willebrand factor A domain containing 8
  • Synonyms
    1300010F03Rik, 4932416F07Rik, mKIAA0564
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919008
    NCBI Gene: 219189
Location & Maps
more
  • Sequence Map
    Chr14:78849178-79202310 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      353133 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.90 cM, cytoband D3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    VWA8, von Willebrand factor A domain containing 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VWA8, von Willebrand factor A domain containing 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0564
  • Links
    NCBI Gene ID: 23078
    neXtProt AC: NX_A3KMH1

  • Chr Location
    13q14.11; chr13:41566825-41961103 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 44881
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: VWA8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    5
  • Genomic Mutations
    1 involving Vwa8
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058997 Ensembl Gene Model | MGI Sequence Detail 353133 C57BL/6J ±  kb
transcript ENSMUST00000040990 Ensembl | MGI Sequence Detail 6928 Not Applicable  
polypeptide ENSMUSP00000048925 Ensembl | MGI Sequence Detail 1905 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3164 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030737 von Willebrand factor A domain-containing protein 8
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011704 ATPase, dynein-related, AAA domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
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  • All nucleic 59
    cDNA 59

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145710
References
more
  • Summaries
    All 37
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory