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Vwa8 Gene Detail
Summary
  • Symbol
    Vwa8
  • Name
    von Willebrand factor A domain containing 8
  • Synonyms
    1300010F03Rik, 4932416F07Rik, mKIAA0564
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919008
    NCBI Gene: 219189
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78849056-79202310 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 41.90 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919008
protein coding gene Chr14:78849052-79202310 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021592
protein coding gene Chr14:73963670-74311464 (+)
A/J MGP_AJ_G0021550
protein coding gene Chr14:72139119-72467601 (+)
AKR/J MGP_AKRJ_G0021527
protein coding gene Chr14:74279863-74620865 (+)
BALB/cJ MGP_BALBcJ_G0021557
protein coding gene Chr14:71976086-72314044 (+)
C3H/HeJ MGP_C3HHeJ_G0021334
protein coding gene Chr14:74010850-74353969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021997
protein coding gene Chr14:77124102-77471486 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019535
protein coding gene Chr14:69699305-70020211 (+)
CAST/EiJ MGP_CASTEiJ_G0020851
protein coding gene Chr14:70796561-71138203 (+)
CBA/J MGP_CBAJ_G0021302
protein coding gene Chr14:79575009-79938203 (+)
DBA/2J MGP_DBA2J_G0021425
protein coding gene Chr14:71529199-71872090 (+)
FVB/NJ MGP_FVBNJ_G0021403
protein coding gene Chr14:70876943-71214531 (+)
LP/J MGP_LPJ_G0021495
protein coding gene Chr14:75057930-75404863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021430
protein coding gene Chr14:78220260-78594456 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022020
protein coding gene Chr14:73596000-73936863 (+)
PWK/PhJ MGP_PWKPhJ_G0020594
protein coding gene Chr14:68326019-68658485 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020431
protein coding gene Chr14:69585443-69910526 (+)
WSB/EiJ MGP_WSBEiJ_G0020904
protein coding gene Chr14:73927857-74287602 (+)



Homology
more
  • Human Ortholog
    VWA8, von Willebrand factor A domain containing 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VWA8, von Willebrand factor A domain containing 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0564, P7BP2
  • Links
    NCBI Gene ID: 23078
    neXtProt AC: NX_A3KMH1
    UniProt: A3KMH1

  • Chr Location
    13q14.11; chr13:41566825-41961111 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 44881
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VWA8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 219189 NCBI Gene Model | MGI Sequence Detail 353255 C57BL/6J ±  kb
    transcript NM_027906 RefSeq | MGI Sequence Detail 6928 C57BL/6  
    polypeptide Q8CC88 UniProt | EBI | MGI Sequence Detail 1905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030737 von Willebrand factor A domain-containing protein 8
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR011704 ATPase, dynein-related, AAA domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR039891 von Willebrand factor A domain-containing protein 8
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 60
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145710
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:264395 Grewe BS, et al., The spatial and developmental expression of mouse Vwa8 (von Willebrand domain-containing protein 8). Gene Expr Patterns. 2018 Apr 13;29:39-46

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory