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Cul2 Gene Detail
Summary
  • Symbol
    Cul2
  • Name
    cullin 2
  • Synonyms
    1300003D18Rik, 4932411N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918995
    NCBI Gene: 71745
  • Gene Overview
    MyGene.info: CUL2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:3382988-3436377 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 2.21 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918995
protein coding gene Chr18:3382970-3436700 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024119
protein coding gene Chr18:171043-225033 (+)
A/J MGP_AJ_G0024081
protein coding gene Chr18:223670-278126 (+)
AKR/J MGP_AKRJ_G0024049
protein coding gene Chr18:227637-284683 (+)
BALB/cJ MGP_BALBcJ_G0024081
protein coding gene Chr18:254602-310068 (+)
C3H/HeJ MGP_C3HHeJ_G0023846
protein coding gene Chr18:186518-251693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024526
protein coding gene Chr18:268681-324685 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021965
protein coding gene Chr18:171065-223423 (+)
CAST/EiJ MGP_CASTEiJ_G0023325
protein coding gene Chr18:202968-256853 (+)
CBA/J MGP_CBAJ_G0023820
protein coding gene Chr18:211385-276507 (+)
DBA/2J MGP_DBA2J_G0023948
protein coding gene Chr18:177994-233474 (+)
FVB/NJ MGP_FVBNJ_G0023914
protein coding gene Chr18:187120-243608 (+)
LP/J MGP_LPJ_G0024032
protein coding gene Chr18:220353-284403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023942
protein coding gene Chr18:232026-290634 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024571
protein coding gene Chr18:183926-238744 (+)
PWK/PhJ MGP_PWKPhJ_G0023070
protein coding gene Chr18:227733-282627 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022881
protein coding gene Chr18:459035-515064 (+)
WSB/EiJ MGP_WSBEiJ_G0023391
protein coding gene Chr18:206551-259266 (+)



Homology
more
  • Human Ortholog
    CUL2, cullin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CUL2, cullin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8453
    neXtProt AC: NX_Q13617
    UniProt: Q13617

  • Chr Location
    10p11.21; chr10:35008551-35126899 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2662
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CUL2
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024231 Ensembl Gene Model | MGI Sequence Detail 53390 C57BL/6J ±  kb
transcript ENSMUST00000162301 Ensembl | MGI Sequence Detail 3828 Not Applicable  
polypeptide ENSMUSP00000125403 Ensembl | MGI Sequence Detail 745 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGI:1922970, MGI:2147215
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:261328 Zou J, et al., Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory