About   Help   FAQ
Nectin4 Gene Detail
Summary
  • Symbol
    Nectin4
  • Name
    nectin cell adhesion molecule 4
  • Synonyms
    1200017F15Rik, nectin 4, Prr4, Pvrl4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918990
    NCBI Gene: 71740
Location & Maps
more
  • Sequence Map
    Chr1:171370099-171388598 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18500 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.37 cM, cytoband H2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NECTIN4, nectin cell adhesion molecule 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NECTIN4, nectin cell adhesion molecule 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDSS1, LNIR, nectin-4, PRR4, PVRL4
  • Links
    NCBI Gene ID: 81607
    neXtProt AC: NX_Q96NY8

  • Chr Location
    1q23.3; chr1:161070991-161089595 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NECTIN4 associations

Human Disease Mouse Models
       Ectodermal Dysplasia-Syndactyly Syndrome 1; EDSS1   OMIM: 613573
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Genomic Mutations
    2 involving Nectin4
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021602 VEGA Gene Model | MGI Sequence Detail 18500 C57BL/6J ±  kb
transcript OTTMUST00000051296 VEGA | MGI Sequence Detail 3201 Not Applicable  
polypeptide OTTMUSP00000024103 VEGA | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    214 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 24
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory