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Lrwd1 Gene Detail
Summary
  • Symbol
    Lrwd1
  • Name
    leucine-rich repeats and WD repeat domain containing 1
  • Synonyms
    1200011O22Rik, Orca
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918985
    NCBI Gene: 71735
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136123066-136136074 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918985
protein coding gene Chr5:136122772-136136074 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030201
protein coding gene Chr5:140747937-140761218 (-)
A/J MGP_AJ_G0030169
protein coding gene Chr5:134688773-134702499 (-)
AKR/J MGP_AKRJ_G0030102
protein coding gene Chr5:139041632-139055512 (-)
BALB/cJ MGP_BALBcJ_G0030179
protein coding gene Chr5:136046557-136059899 (-)
C3H/HeJ MGP_C3HHeJ_G0029895
protein coding gene Chr5:139662516-139675866 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030632
protein coding gene Chr5:145983355-145996647 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027852
protein coding gene Chr5:128975029-128980262 (-)
CAST/EiJ MGP_CASTEiJ_G0029305
protein coding gene Chr5:139061885-139076564 (-)
CBA/J MGP_CBAJ_G0029865
protein coding gene Chr5:151688146-151701427 (-)
DBA/2J MGP_DBA2J_G0030016
protein coding gene Chr5:134589402-134602716 (-)
FVB/NJ MGP_FVBNJ_G0029971
protein coding gene Chr5:133742925-133757073 (-)
LP/J MGP_LPJ_G0030105
protein coding gene Chr5:141174576-141188101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030003
protein coding gene Chr5:154659301-154674842 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030672
protein coding gene Chr5:138859141-138873655 (-)
PWK/PhJ MGP_PWKPhJ_G0029018
protein coding gene Chr5:133648281-133661702 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028854
protein coding gene Chr5:136407765-136422869 (-)
WSB/EiJ MGP_WSBEiJ_G0029378
protein coding gene Chr5:139581731-139595019 (-)



Homology
more
  • Human Ortholog
    LRWD1, leucine rich repeats and WD repeat domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRWD1, leucine rich repeats and WD repeat domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CENP-33, ORCA
  • Links
    NCBI Gene ID: 222229
    neXtProt AC: NX_Q9UFC0
    UniProt: Q9UFC0

  • Chr Location
    7q22.1; chr7:102464883-102473168 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17678
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRWD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71735 NCBI Gene Model | MGI Sequence Detail 13009 C57BL/6J ±  kb
transcript NM_027891 RefSeq | MGI Sequence Detail 2201 C57BL/6  
polypeptide Q8BUI3 UniProt | EBI | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141087, MGI:2141221
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:185051 Chan KM, et al., Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. J Biol Chem. 2012 Apr 27;287(18):15024-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory