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Lrwd1 Gene Detail
Summary
  • Symbol
    Lrwd1
  • Name
    leucine-rich repeats and WD repeat domain containing 1
  • Synonyms
    1200011O22Rik, Orca
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918985
    NCBI Gene: 71735
Location & Maps
more
  • Sequence Map
    Chr5:136122772-136136074 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13303 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.80 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LRWD1, leucine rich repeats and WD repeat domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRWD1, leucine rich repeats and WD repeat domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CENP-33, ORCA
  • Links
    NCBI Gene ID: 222229
    neXtProt AC: NX_Q9UFC0

  • Chr Location
    7q22.1; chr7:102464943-102473168 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 17678
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRWD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    6
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025432 VEGA Gene Model | MGI Sequence Detail 13303 C57BL/6J ±  kb
transcript OTTMUST00000062622 VEGA | MGI Sequence Detail 2473 Not Applicable  
polypeptide OTTMUSP00000030901 VEGA | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    15 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141087, MGI:2141221
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:185051 Chan KM, et al., Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. J Biol Chem. 2012 Apr 27;287(18):15024-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory