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Pan2 Gene Detail
Summary
  • Symbol
    Pan2
  • Name
    PAN2 poly(A) specific ribonuclease subunit
  • Synonyms
    1200014O24Rik, Usp52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918984
    NCBI Gene: 103135
  • Gene Overview
    MyGene.info: PAN2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128303335-128321358 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918984
protein coding gene Chr10:128303331-128321358 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017858
protein coding gene Chr10:132024477-132042608 (+)
A/J MGP_AJ_G0017833
protein coding gene Chr10:126728436-126746251 (+)
AKR/J MGP_AKRJ_G0017796
protein coding gene Chr10:130453566-130471579 (+)
BALB/cJ MGP_BALBcJ_G0017797
protein coding gene Chr10:127111590-127130666 (+)
C3H/HeJ MGP_C3HHeJ_G0017620
protein coding gene Chr10:130614869-130634847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018252
protein coding gene Chr10:136502727-136524441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015930
protein coding gene Chr10:120662516-120681630 (+)
CAST/EiJ MGP_CASTEiJ_G0017181
protein coding gene Chr10:131318705-131338849 (+)
CBA/J MGP_CBAJ_G0017590
protein coding gene Chr10:142045716-142066908 (+)
DBA/2J MGP_DBA2J_G0017696
protein coding gene Chr10:125789501-125807504 (+)
FVB/NJ MGP_FVBNJ_G0017691
protein coding gene Chr10:124717671-124736140 (+)
LP/J MGP_LPJ_G0017770
protein coding gene Chr10:132622668-132641065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017719
protein coding gene Chr10:144633795-144651813 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018292
protein coding gene Chr10:130546663-130565827 (+)
PWK/PhJ MGP_PWKPhJ_G0016966
protein coding gene Chr10:126048547-126067662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016755
protein coding gene Chr10:129637512-129657997 (+)
WSB/EiJ MGP_WSBEiJ_G0017240
protein coding gene Chr10:130763690-130781674 (+)



Homology
more
  • Human Ortholog
    PAN2, poly(A) specific ribonuclease subunit PAN2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAN2, poly(A) specific ribonuclease subunit PAN2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    USP52
  • Links
    NCBI Gene ID: 9924
    neXtProt AC: NX_Q504Q3
    UniProt: Q504Q3

  • Chr Location
    12q13.3; chr12:56316223-56334053 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5918
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PAN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005682 Ensembl Gene Model | MGI Sequence Detail 18024 C57BL/6J ±  kb
transcript ENSMUST00000005825 Ensembl | MGI Sequence Detail 4445 Not Applicable  
polypeptide ENSMUSP00000005825 Ensembl | MGI Sequence Detail 1200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143521, MGI:2143882
References
more
  • Summaries
    All 36
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory