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Pan2 Gene Detail
Summary
  • Symbol
    Pan2
  • Name
    PAN2 poly(A) specific ribonuclease subunit
  • Synonyms
    1200014O24Rik, Usp52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918984
    NCBI Gene: 103135
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128139204-128157227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918984
 protein coding gene Chr10:128135106-128157227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017858
 protein coding gene Chr10:132024477-132042608 (+)
A/J MGP_AJ_G0017833
 protein coding gene Chr10:126728436-126746251 (+)
AKR/J MGP_AKRJ_G0017796
 protein coding gene Chr10:130453566-130471579 (+)
BALB/cJ MGP_BALBcJ_G0017797
 protein coding gene Chr10:127111590-127130666 (+)
C3H/HeJ MGP_C3HHeJ_G0017620
 protein coding gene Chr10:130614869-130634847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018252
 protein coding gene Chr10:136502727-136524441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015930
 protein coding gene Chr10:120662516-120681630 (+)
CAST/EiJ MGP_CASTEiJ_G0017181
 protein coding gene Chr10:131318705-131338849 (+)
CBA/J MGP_CBAJ_G0017590
 protein coding gene Chr10:142045716-142066908 (+)
DBA/2J MGP_DBA2J_G0017696
 protein coding gene Chr10:125789501-125807504 (+)
FVB/NJ MGP_FVBNJ_G0017691
 protein coding gene Chr10:124717671-124736140 (+)
LP/J MGP_LPJ_G0017770
 protein coding gene Chr10:132622668-132641065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017719
 protein coding gene Chr10:144633795-144651813 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018292
 protein coding gene Chr10:130546663-130565827 (+)
PWK/PhJ MGP_PWKPhJ_G0016966
 protein coding gene Chr10:126048547-126067662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016755
 protein coding gene Chr10:129637512-129657997 (+)
WSB/EiJ MGP_WSBEiJ_G0017240
 protein coding gene Chr10:130763690-130781674 (+)



Homology
more
  • Human Ortholog
    PAN2, poly(A) specific ribonuclease subunit PAN2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAN2, poly(A) specific ribonuclease subunit PAN2
  • Synonyms
    USP52
  • Links
    NCBI Gene ID: 9924
    neXtProt AC: NX_Q504Q3
    UniProt: Q504Q3

  • Chr Location
    12q13.3; chr12:56316223-56334053 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    22
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005682 Ensembl Gene Model | MGI Sequence Detail 18024 C57BL/6J ±  kb
    transcript ENSMUST00000005825 Ensembl | MGI Sequence Detail 4445 Not Applicable  
    polypeptide ENSMUSP00000005825 Ensembl | MGI Sequence Detail 1200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012253 PAN2-PAN3 deadenylation complex catalytic subunit PAN2
      (term hierarchy)
    • EC
      3.1.13.4
    • InterPro Domains
      IPR013520 Exonuclease, RNase T/DNA polymerase III
      IPR030843 PAN2-PAN3 deadenylation complex catalytic subunit PAN2
      IPR048841 PAN2-PAN3 deadenylation complex catalytic subunit PAN2, N-terminal
      IPR028881 PAN2, UCH domain
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR012337 Ribonuclease H-like superfamily
      IPR036397 Ribonuclease H superfamily
      IPR028889 Ubiquitin specific protease domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143521, MGI:2143882
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:285122 Sha QQ, et al., Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse. Nucleic Acids Res. 2020 Jan 24;48(2):879-894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory