Rgs12 MGI Mouse Gene Detail - MGI:1918979 - regulator of G-protein signaling 12

Symbol

Rgs12
Name

regulator of G-protein signaling 12
Synonyms

1200016K18Rik, 4632412M04Rik

Feature Type

protein coding gene
IDs

MGI:1918979
NCBI Gene: 71729
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:35106789-35196988 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.96 cM
Mapping Data

3 experiments

SNPs within 2kb

2000 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918979	protein coding gene	Chr5:35106273-35196988 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029473	protein coding gene	Chr5:33204700-33300663 (+)
A/J	MGP_AJ_G0029440	protein coding gene	Chr5:32124925-32218021 (+)
AKR/J	MGP_AKRJ_G0029389	protein coding gene	Chr5:33354188-33449459 (+)
BALB/cJ	MGP_BALBcJ_G0029450	protein coding gene	Chr5:32650189-32740292 (+)
C3H/HeJ	MGP_C3HHeJ_G0029172	protein coding gene	Chr5:33381260-33476422 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029904	protein coding gene	Chr5:35107383-35199733 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027141	protein coding gene	Chr5:29888840-29977518 (+)
CAST/EiJ	MGP_CASTEiJ_G0028581	protein coding gene	Chr5:32455763-32550741 (+)
CBA/J	MGP_CBAJ_G0029140	protein coding gene	Chr5:35921823-36017510 (+)
DBA/2J	MGP_DBA2J_G0029288	protein coding gene	Chr5:32276349-32366116 (+)
FVB/NJ	MGP_FVBNJ_G0029247	protein coding gene	Chr5:31721358-31812661 (+)
LP/J	MGP_LPJ_G0029373	protein coding gene	Chr5:33626603-33720519 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029277	protein coding gene	Chr5:36761123-36853176 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029937	protein coding gene	Chr5:32859787-32953435 (+)
PWK/PhJ	MGP_PWKPhJ_G0028306	protein coding gene	Chr5:31432498-31524437 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028137	protein coding gene	Chr5:32300139-32396504 (+)
WSB/EiJ	MGP_WSBEiJ_G0028662	protein coding gene	Chr5:32924040-33018103 (+)

Human Ortholog

RGS12, regulator of G protein signaling 12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS12, regulator of G protein signaling 12
Links

HGNC:9994

NCBI Gene ID: 6002

UniProt: O14924
Chr Location

4p16.3; chr4:3285891-3439913 (+) GRCh38

MGI Vertebrate Homology

Rgs12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS12
Gene Tree

Rgs12

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

7
Radiation induced

4
Spontaneous

1
Targeted

9
Genomic Mutations

8 involving Rgs12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

25
cDNA Data

126
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs12

ZFIN rgs12b

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All Sequences

121
RefSeq

39
UniProt

15
CCDS

CCDS19222.1, CCDS51472.1

Ensembl

ENSMUSG00000029101 (Evidence)
NCBI Gene

71729

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029101	Ensembl Gene Model \| MGI Sequence Detail	90200	C57BL/6J	± kb
transcript	ENSMUST00000087684	Ensembl \| MGI Sequence Detail	4713	Not Applicable
polypeptide	ENSMUSP00000084970	Ensembl \| MGI Sequence Detail	1451	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000013947 regulator of G-protein signaling 12

(term hierarchy)
InterPro Domains

IPR003109 GoLoco motif

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain

IPR003116 Raf-like Ras-binding

IPR046995 Regulator of G-protein signaling 10/12/14-like

IPR037880 RGS12, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q8CGE9 2 sites, 1 O-linked glycan (1 site)

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All nucleic 126

cDNA 126

Microarray probesets 6

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MGI:1924302, MGI:2140916

Summaries

All 74

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 39
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:330604 Akturk A, et al., RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells. Sci Adv. 2022 Oct 21;8(42):eabq2826

TSS for Rgs12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45909	Chr5:35106708-35106713 (+)	-78 bp
Tssr45910	Chr5:35106779-35106848 (+)	25 bp
Tssr45911	Chr5:35132158-35132169 (+)	25,375 bp
Tssr45912	Chr5:35132325-35132343 (+)	25,545 bp
Tssr45913	Chr5:35132476-35132517 (+)	25,708 bp
Tssr45914	Chr5:35132588-35132600 (+)	25,805 bp
Tssr45915	Chr5:35146727-35146747 (+)	39,948 bp
Tssr45916	Chr5:35146880-35146889 (+)	40,096 bp
Tssr45917	Chr5:35146974-35147019 (+)	40,208 bp
Tssr45918	Chr5:35147041-35147063 (+)	40,263 bp
Tssr45919	Chr5:35147070-35147120 (+)	40,306 bp
Tssr45920	Chr5:35156390-35156413 (+)	49,613 bp
Tssr45921	Chr5:35156414-35156430 (+)	49,633 bp
Tssr45922	Chr5:35156455-35156461 (+)	49,669 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/07/2025 MGI 6.24