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Rgs12
Gene Detail
Symbol

Name
ID
Rgs12
regulator of G-protein signaling 12
MGI:1918979
Synonyms
1200016K18Rik, 4632412M04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:34949445-35039644 bp, + strand
From VEGA annotation of GRCm38

  90200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS12/RGS14 types
Gene Tree: Rgs12

Human
homologs
Human Homolog RGS12, regulator of G-protein signaling 12
NCBI Gene ID 6002
neXtProt AC  NX_O14924
Human Chr (Location)  4p16.3; chr4:3292978-3439913 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(7) Radiation induced(4) Targeted(6)
Genomic Mutations involving Rgs12 (5)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(4)   
Interactions
Rgs12 interacts with 136 markers (Mir7-1, Mir15a, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process positive regulation of GTPase activity, regulation of catalytic activity, ...
Component apical dendrite, cytoplasm, ...
Function G-protein alpha-subunit binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (24)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 42
cDNA source data(125)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(125) cDNA(125)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000023191 (Evidence)
Ensembl Gene ModelENSMUSG00000029101 (Evidence)
Entrez Gene71729 (Evidence)
UniGene196208
DFCITC1590211, TC1575711
DoTSDT.526951, DT.94339445, DT.40185924, DT.101737963, DT.99858208
Consensus CDS ProjectCCDS19222.1, CCDS51472.1
International Mouse Knockout Project StatusRgs12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023191 VEGA Gene Model | MGI Sequence Detail 90200 C57BL/6J ±  kb
transcript OTTMUST00000056223 VEGA | MGI Sequence Detail 4713 Not Applicable 
polypeptide OTTMUSP00000026991 VEGA | MGI Sequence Detail 1451 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(19) UniProt(25)
Polymorphisms
RFLP(1) : SNPs within 2kb(495 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003109 GoLoco motif
InterPro IPR001478 PDZ domain
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR003116 Raf-like Ras-binding
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013947 regulator of G-protein signaling 12
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(43)
Other
accession IDs
MGI:1924302, MGI:2140916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory