Osbpl3 MGI Mouse Gene Detail - MGI:1918970 - oxysterol binding protein-like 3

Osbpl3 Gene Detail

Symbol

Osbpl3
Name

oxysterol binding protein-like 3
Synonyms

1200014M06Rik, 6720421I08Rik, ORP3, OSBP3

Feature Type

protein coding gene
IDs

MGI:1918970
NCBI Gene: 71720
Gene Overview

MyGene.info: OSBPL3
Alliance

gene page

Sequence Map

Chr6:50293330-50456201 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

162872 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 24.13 cM, cytoband B3
Mapping Data

3 experiments

Human Ortholog

OSBPL3, oxysterol binding protein like 3

Vertebrate Orthologs

10

Human Ortholog

OSBPL3, oxysterol binding protein like 3
Orthology source: HomoloGene, HGNC
Synonyms

ORP3, ORP-3, OSBP3
Links

HGNC:16370

NCBI Gene ID: 26031

neXtProt AC: NX_Q9H4L5

UniProt: Q9H4L5
Chr Location

7p15.3; chr7:24796537-24980218 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 49422
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: OSBPL3
Gene Tree

Osbpl3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Gene trapped

26
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

49 strains or lines available

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All GO Annotations

13
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

188
Tissues

42
cDNA Data

13
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Osbpl3 interacts with 382 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

79
RefSeq

20
UniProt

8
CCDS

CCDS39489.1, CCDS51771.1, CCDS85046.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022235	VEGA Gene Model \| MGI Sequence Detail	162872	C57BL/6J	± kb
transcript	OTTMUST00000052901	VEGA \| MGI Sequence Detail	4039	Not Applicable
polypeptide	OTTMUSP00000025133	VEGA \| MGI Sequence Detail	886	Not Applicable

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SNPs within 2kb

1633 from dbSNP Build 142

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UniProt

8 Sequences
Protein Ontology

PR:000012049 oxysterol-binding protein-related protein 3

(term hierarchy)
InterPro Domains

IPR000648 Oxysterol-binding protein

IPR018494 Oxysterol-binding protein, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 5

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MGI:1924397

Summaries

All 35

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 9
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:193047 Revil T, et al., During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes. Dev Dyn. 2013 Mar;242(3):281-90

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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