Osbpl3 MGI Mouse Gene Detail - MGI:1918970 - oxysterol binding protein-like 3

Symbol

Osbpl3
Name

oxysterol binding protein-like 3
Synonyms

1200014M06Rik, 6720421I08Rik, ORP3, OSBP3

Feature Type

protein coding gene
IDs

MGI:1918970
NCBI Gene: 71720
Gene Overview

MyGene.info: OSBPL3
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:50293330-50456201 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 24.13 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

1633 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918970	protein coding gene	Chr6:50293327-50456354 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030729	protein coding gene	Chr6:49393831-49565192 (-)
A/J	MGP_AJ_G0030700	protein coding gene	Chr6:47089330-47255375 (-)
AKR/J	MGP_AKRJ_G0030625	protein coding gene	Chr6:48747512-48913318 (-)
BALB/cJ	MGP_BALBcJ_G0030710	protein coding gene	Chr6:47431184-47598905 (-)
C3H/HeJ	MGP_C3HHeJ_G0030423	protein coding gene	Chr6:48768371-48939131 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031165	protein coding gene	Chr6:50501182-50679844 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028372	protein coding gene	Chr6:44699521-44866330 (-)
CAST/EiJ	MGP_CASTEiJ_G0029827	protein coding gene	Chr6:48478899-48647196 (-)
CBA/J	MGP_CBAJ_G0030398	protein coding gene	Chr6:52629594-52813513 (-)
DBA/2J	MGP_DBA2J_G0030547	protein coding gene	Chr6:47002490-47165890 (-)
FVB/NJ	MGP_FVBNJ_G0030499	protein coding gene	Chr6:46642511-46806980 (-)
LP/J	MGP_LPJ_G0030632	protein coding gene	Chr6:49341913-49524495 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030533	protein coding gene	Chr6:55338615-55518004 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031194	protein coding gene	Chr6:48661790-48831554 (-)
PWK/PhJ	MGP_PWKPhJ_G0029539	protein coding gene	Chr6:46572959-46739164 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029375	protein coding gene	Chr6:47989052-48162010 (-)
WSB/EiJ	MGP_WSBEiJ_G0029904	protein coding gene	Chr6:48626154-48798332 (-)

Human Ortholog

OSBPL3, oxysterol binding protein like 3

Vertebrate Orthologs

10

Human Ortholog

OSBPL3, oxysterol binding protein like 3
Orthology source: HomoloGene, HGNC
Synonyms

ORP3, ORP-3, OSBP3
Links

HGNC:16370

NCBI Gene ID: 26031

neXtProt AC: NX_Q9H4L5

UniProt: Q9H4L5
Chr Location

7p15.3; chr7:24796537-24980218 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 49422
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: OSBPL3
Gene Tree

Osbpl3

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Gene trapped

26
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

188
Tissues

42
cDNA Data

14
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase osbpl3

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Osbpl3 interacts with 382 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

85
RefSeq

26
UniProt

8
CCDS

CCDS39489.1, CCDS51771.1, CCDS85046.1

Ensembl

ENSMUSG00000029822 (Evidence)
NCBI Gene

71720

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029822	Ensembl Gene Model \| MGI Sequence Detail	162872	C57BL/6J	± kb
transcript	ENSMUST00000090019	Ensembl \| MGI Sequence Detail	4039	Not Applicable
polypeptide	ENSMUSP00000087473	Ensembl \| MGI Sequence Detail	886	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012049 oxysterol-binding protein-related protein 3

(term hierarchy)
InterPro Domains

IPR000648 Oxysterol-binding protein

IPR018494 Oxysterol-binding protein, conserved site

IPR037239 Oxysterol-binding protein superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR041680 Pleckstrin homology domain 8

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 5

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MGI:1924397

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 9
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:193047 Revil T, et al., During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes. Dev Dyn. 2013 Mar;242(3):281-90

TSS for Osbpl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60916	Chr6:50456353-50456362 (-)	-157 bp
Tssr60915	Chr6:50456085-50456174 (-)	71 bp
Tssr60913	Chr6:50397068-50397077 (-)	59,128 bp
Tssr60905	Chr6:50382925-50382936 (-)	73,270 bp
Tssr60904	Chr6:50382902-50382913 (-)	73,293 bp
Tssr60903	Chr6:50382831-50382847 (-)	73,362 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/10/2019 MGI 6.14