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Ubiad1 Gene Detail
Summary
  • Symbol
    Ubiad1
  • Name
    UbiA prenyltransferase domain containing 1
  • Synonyms
    1200002M06Rik, Tere1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918957
    NCBI Gene: 71707
  • Gene Overview
    MyGene.info: UBIAD1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148518952-148529217 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.76 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918957
protein coding gene Chr4:148518952-148529228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029123
protein coding gene Chr4:152153141-152165485 (-)
A/J MGP_AJ_G0029088
protein coding gene Chr4:145865541-145875896 (-)
AKR/J MGP_AKRJ_G0029036
protein coding gene Chr4:149838090-149848209 (-)
BALB/cJ MGP_BALBcJ_G0029104
protein coding gene Chr4:146370589-146380818 (-)
C3H/HeJ MGP_C3HHeJ_G0028825
protein coding gene Chr4:150399738-150410882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029553
protein coding gene Chr4:157691896-157702194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026799
protein coding gene Chr4:138283783-138293696 (-)
CAST/EiJ MGP_CASTEiJ_G0028238
protein coding gene Chr4:147606616-147617549 (-)
CBA/J MGP_CBAJ_G0028787
protein coding gene Chr4:162261048-162271511 (-)
DBA/2J MGP_DBA2J_G0028936
protein coding gene Chr4:145970501-145980934 (-)
FVB/NJ MGP_FVBNJ_G0028900
protein coding gene Chr4:145063952-145074166 (-)
LP/J MGP_LPJ_G0029026
protein coding gene Chr4:152119823-152131002 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028927
protein coding gene Chr4:165579233-165598081 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029585
protein coding gene Chr4:150322501-150332809 (-)
PWK/PhJ MGP_PWKPhJ_G0027958
protein coding gene Chr4:141959938-141970256 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027792
protein coding gene Chr4:144583523-144593642 (-)
WSB/EiJ MGP_WSBEiJ_G0028318
protein coding gene Chr4:150490513-150500764 (-)



Homology
more
  • Human Ortholog
    UBIAD1, UbiA prenyltransferase domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBIAD1, UbiA prenyltransferase domain containing 1
  • Synonyms
    SCCD, TERE1
  • Links
    NCBI Gene ID: 29914
    neXtProt AC: NX_Q9Y5Z9
    UniProt: Q9Y5Z9

  • Chr Location
    1p36.22; chr1:11273198-11299578 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ubiad1 mouse models; 1 with human UBIAD1 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality, reduced embryo size, failure to form the primitive streak, no mesoderm and inability to synthesize menaquinone 4.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71707 NCBI Gene Model | MGI Sequence Detail 10266 C57BL/6J ±  kb
    transcript NM_027873 RefSeq | MGI Sequence Detail 2997 C57BL/6  
    polypeptide Q9DC60 UniProt | EBI | MGI Sequence Detail 336 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 65

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140264, MGI:2140569
    References
    more
    • Summaries
      All 39
      Diseases 1
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:290732 Jo Y, et al., Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency. Elife. 2020 Mar 2;9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/23/2021
    MGI 6.17
    The Jackson Laboratory