Slc46a3 MGI Mouse Gene Detail - MGI:1918956 - solute carrier family 46, member 3

Symbol

Slc46a3
Name

solute carrier family 46, member 3
Synonyms

1200006F02Rik

Feature Type

protein coding gene
IDs

MGI:1918956
NCBI Gene: 71706
Gene Overview

MyGene.info: SLC46A3
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:147815247-147831625 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 87.58 cM, cytoband G3
Mapping Data

2 experiments

SNPs within 2kb

18 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918956	protein coding gene	Chr5:147812707-147831670 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030393	protein coding gene	Chr5:153580484-153597525 (-)
A/J	MGP_AJ_G0030366	protein coding gene	Chr5:147059929-147076111 (-)
AKR/J	MGP_AKRJ_G0030293	protein coding gene	Chr5:151577866-151594051 (-)
BALB/cJ	MGP_BALBcJ_G0030375	protein coding gene	Chr5:148279385-148296031 (-)
C3H/HeJ	MGP_C3HHeJ_G0030089	protein coding gene	Chr5:152545235-152562318 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030830	protein coding gene	Chr5:159207965-159235624 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028043	protein coding gene	Chr5:141463521-141481366 (-)
CAST/EiJ	MGP_CASTEiJ_G0029491	protein coding gene	Chr5:152125888-152142219 (-)
CBA/J	MGP_CBAJ_G0030067	protein coding gene	Chr5:165864865-165880988 (-)
DBA/2J	MGP_DBA2J_G0030211	protein coding gene	Chr5:146732444-146748607 (-)
FVB/NJ	MGP_FVBNJ_G0030165	protein coding gene	Chr5:145937539-145953560 (-)
LP/J	MGP_LPJ_G0030298	protein coding gene	Chr5:154266571-154283843 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030201	protein coding gene	Chr5:168089251-168107312 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030860	protein coding gene	Chr5:151494862-151511027 (-)
PWK/PhJ	MGP_PWKPhJ_G0029205	protein coding gene	Chr5:145848358-145865606 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029041	protein coding gene	Chr5:148839860-148857528 (-)
WSB/EiJ	MGP_WSBEiJ_G0029568	protein coding gene	Chr5:152302219-152319919 (-)

Human Ortholog

SLC46A3, solute carrier family 46 member 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC46A3, solute carrier family 46 member 3
Synonyms

FKSG16
Links

HGNC:27501

NCBI Gene ID: 283537

neXtProt AC: NX_Q7Z3Q1

UniProt: Q7Z3Q1
Chr Location

13q12.3; chr13:28700080-28719013 (-) GRCh38.p7

Alliance of Genome Resources

Slc46a3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC46A3
Gene Tree

Slc46a3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Gene trapped

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

39
cDNA Data

39
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Slc46a3 interacts with 142 markers (Mir18b, Mir19a, Mir19b-1, ...) View All

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All Sequences

41
RefSeq

8
UniProt

2
CCDS

CCDS19880.1

Ensembl

ENSMUSG00000029650 (Evidence)
NCBI Gene

71706

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029650	Ensembl Gene Model \| MGI Sequence Detail	16379	C57BL/6J	± kb
transcript	ENSMUST00000118527	Ensembl \| MGI Sequence Detail	2210	Not Applicable
polypeptide	ENSMUSP00000113879	Ensembl \| MGI Sequence Detail	460	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031959 solute carrier family 46 member 3

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR036259 MFS transporter superfamily

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All nucleic 40

cDNA 39

Primer pair 1

Microarray probesets 4

Summaries

All 33

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:300865 Kim JH, et al., Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis. Nat Commun. 2021 Jan 12;12(1):290

TSS for Slc46a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54544	Chr5:147831651-147831659 (-)	-30 bp
Tssr54543	Chr5:147831641-147831648 (-)	-20 bp
Tssr54542	Chr5:147831614-147831640 (-)	-2 bp
Tssr54541	Chr5:147831597-147831608 (-)	22 bp
Tssr54540	Chr5:147831587-147831596 (-)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/19/2021 MGI 6.17