Pnpt1
Gene Detail

Symbol Name ID

Pnpt1 polyribonucleotide nucleotidyltransferase 1 MGI:1918951

Synonyms

1200003F12Rik, PNPase, polynucleotide phosphorylase

Feature Type

protein coding gene

Genetic Map

Chromosome 11

16.46 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:29130744-29161828 bp, + strand From VEGA annotation of GRCm38   31085 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12404  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: polyribonucleotide nucleotidyltransferase
Gene Tree: Pnpt1

Human homologs

Human Homolog		PNPT1, polyribonucleotide nucleotidyltransferase 1
NCBI Gene ID		87178
neXtProt AC		NX_Q8TCS8
Human Synonyms		COXPD13, DFNB70, old-35, OLD35, PNPASE
Human Chr (Location)		2p15; chr2:55861198-55921011 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PNPT1

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality and impaired mitochondrial RNA import.

 

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	cellular response to interferon-beta, cellular response to oxidative stress, ...
Component	cytoplasm, membrane, ...
Function	3'-5'-exoribonuclease activity, exonuclease activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (22)    Tissues (22)    Images (4)
Theiler Stages: 21, 28

Assay Type	Results
RNA in situ	20
RT-PCR	2

cDNA source data(103)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(104) cDNA(103) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005318 (Evidence)
Ensembl Gene Model	ENSMUSG00000020464 (Evidence)
Entrez Gene	71701 (Evidence)
UniGene	211131
DFCI	TC1575492, TC1594517, TC1616664, TC1693698
DoTS	DT.530926, DT.94198329, DT.99843987
NIA Mouse Gene Index	U012401
EC	2.7.7.8
PDB	1WHU
Consensus CDS Project	CCDS24490.1
International Mouse Knockout Project Status	Pnpt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005318	VEGA Gene Model | MGI Sequence Detail	31085	C57BL/6J
transcript	OTTMUST00000011847	VEGA | MGI Sequence Detail	2707	Not Applicable
polypeptide	OTTMUSP00000005486	VEGA | MGI Sequence Detail	783	Not Applicable

All sequences(52) RefSeq(10) UniProt(4)

Polymorphisms

SNPs(125 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001247	Exoribonuclease, phosphorolytic domain 1
InterPro	IPR015847	Exoribonuclease, phosphorolytic domain 2
InterPro	IPR004087	K Homology domain
InterPro	IPR004088	K Homology domain, type 1
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
InterPro	IPR015848	Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type
InterPro	IPR012162	Polyribonucleotide nucleotidyltransferase
InterPro	IPR003029	Ribosomal protein S1, RNA-binding domain
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
InterPro	IPR022967	RNA-binding domain, S1
Protein Ontology	PR:000012950	polyribonucleotide nucleotidyltransferase 1, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:182223 Wang G, et al., Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4840-5
All references(37)