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Optn
Gene Detail
Symbol

Name
ID
Optn
optineurin
MGI:1918898
Synonyms
4930441O07Rik, TFIIIA-INTP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
3.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:5020642-5064051 bp, - strand
From VEGA annotation of GRCm38

  43410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OPTN
Gene Tree: Optn

Human
homologs
OPTN, optineurin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10133
neXtProt AC: NX_Q96CV9

Human Synonyms: ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP

Human Chr (Location): 10p13; chr10:13100075-13138291 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human OPTN

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice hypomorphic allele exhibit background sensitive embryonic lethality with surviving mice exhibiting normal immune cell development, T and B cell activation and TNF- or LPS-mediated activation of cells of the innate immune system.
 
Interactions
Optn interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process autophagy, cellular protein localization, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function identical protein binding, K63-linked polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (212)    Tissues (142)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 190
Northern blot 8
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase optn ; ZFIN optn    NEW 
Molecular
reagents
All nucleic(37) cDNA(35) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010864 (Evidence)
Ensembl Gene Model ENSMUSG00000026672 (Evidence)
Entrez Gene 71648 (Evidence)
UniGene 116942
DFCI TC1619478, TC1581450
DoTS DT.101721508, DT.40138669, DT.91583612, DT.91303083
NIA Mouse Gene Index U022253
Consensus CDS Project CCDS15663.1
International Mouse Phenotyping Consortium Status Optn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010864 VEGA Gene Model | MGI Sequence Detail 43410 C57BL/6J ±  kb
transcript OTTMUST00000025422 VEGA | MGI Sequence Detail 2614 Not Applicable 
polypeptide OTTMUSP00000011649 VEGA | MGI Sequence Detail 584 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(397 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Protein Ontology PR:000011652 optineurin
References
(Earliest) J:61878 Moreland RJ, et al., Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 2000 May 1;28(9):1986-93
(Latest) J:207113 Munitic I, et al., Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells. J Immunol. 2013 Dec 15;191(12):6231-40
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory