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Optn
Gene Detail
 Symbol
Name
ID
Optn
optineurin
MGI:1918898
Synonyms 4930441O07Rik, TFIIIA-INTP
Feature Type protein coding gene
Genetic Map
Chromosome 2
3.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:5020642-5064051 bp, - strand
From VEGA annotation of GRCm38

  43410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11085  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Optn

Human
homologs
Human Homolog OPTN, optineurin
NCBI Gene ID 10133
neXtProt AC  NX_Q96CV9
Human Synonyms  ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Human Chr (Location)  10p13; chr10:13100075-13138291 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human OPTN
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(11) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice hypomorphic allele exhibit background sensitive embryonic lethality with surviving mice exhibiting normal immune cell development, T and B cell activation and TNF- or LPS-mediated activation of cells of the innate immune system.
 
Interactions
Optn interacts with 154 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cellular protein localization, cytokine secretion, ...
Component cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function identical protein binding, K63-linked polyubiquitin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (212)    Tissues (142)    Images (17)
Theiler Stages: 14, 17, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 14
RNA in situ 190
Northern blot 8
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(35) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010864 (Evidence)
Ensembl Gene ModelENSMUSG00000026672 (Evidence)
Entrez Gene71648 (Evidence)
UniGene116942
DFCITC1581450, TC1619478
DoTSDT.101721508, DT.40138669, DT.91303083, DT.91583612
NIA Mouse Gene IndexU022253
Consensus CDS ProjectCCDS15663.1
International Mouse Knockout Project StatusOptn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010864 VEGA Gene Model | MGI Sequence Detail 43410 C57BL/6J ±  kb
transcript OTTMUST00000025422 VEGA | MGI Sequence Detail 2614 Not Applicable 
polypeptide OTTMUSP00000011649 VEGA | MGI Sequence Detail 584 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(397 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Protein Ontology PR:000011652 optineurin
References (Earliest) J:61878 Moreland RJ, et al., Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 2000 May 1;28(9):1986-93
(Latest) J:207113 Munitic I, et al., Optineurin insufficiency impairs IRF3 but not NF-kappaB activation in immune cells. J Immunol. 2013 Dec 15;191(12):6231-40
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory