Optn
Gene Detail

Symbol Name ID

Optn optineurin MGI:1918898

Synonyms

4930441O07Rik, TFIIIA-INTP

Feature Type

protein coding gene

Genetic Map

Chromosome 2

3.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:5020642-5064051 bp, - strand From VEGA annotation of GRCm38   43410 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Optn ± 2 cM)

Gene Tree: Optn

Human ortholog

OPTN optineurin NCBI Gene ID 10133
Human Synonyms: ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Human Chr10:13142082-13180276 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human OPTN (3)

Alleles and phenotypes

All alleles(13) : Targeted(2) Gene trapped(11)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cellular protein localization, Golgi organization, ...
Component	cytoplasm, cytoplasmic membrane-bounded vesicle, ...
Function	identical protein binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (187)    Tissues (118)    Images (15)
Theiler Stages: 14, 17, 22, 23, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	165
Northern blot	8

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010864 (Evidence)
Ensembl Gene Model	ENSMUSG00000026672 (Evidence)
Entrez Gene	71648 (Evidence)
DFCI	TC1581450, TC1619478
DoTS	DT.101721508, DT.40138669, DT.91303083, DT.91583612
NIA Mouse Gene Index	U022253
Consensus CDS Project	CCDS15663.1
International Mouse Knockout Project Status	Optn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010864	VEGA Gene Model | MGI Sequence Detail	43410	C57BL/6J
transcript	OTTMUST00000025422	VEGA | MGI Sequence Detail	2614	Not Applicable
polypeptide	OTTMUSP00000011649	VEGA | MGI Sequence Detail	584	Not Applicable

All sequences(34) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(236 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021063	NF-kappa-B essential modulator NEMO, N-terminal
Protein Ontology	PR:000011652	optineurin

References

(Earliest) J:61878 Moreland RJ, et al., Identification of a transcription factor IIIA-interacting protein. Nucleic Acids Res. 2000 May 1;28(9):1986-93
(Latest) J:189367 Sippl C, et al., Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins. Exp Eye Res. 2011 Nov;93(5):669-80
All references(41)