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Mast4 Gene Detail
Summary
  • Symbol
    Mast4
  • Name
    microtubule associated serine/threonine kinase family member 4
  • Synonyms
    4930420O11Rik, mKIAA0303
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918885
    NCBI Gene: 328329
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:102868994-103471005 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 54.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5090 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918885
 protein coding gene Chr13:102868994-103471607 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020899
 protein coding gene Chr13:104789677-105412746 (-)
A/J MGP_AJ_G0020850
 protein coding gene Chr13:100700481-101301371 (-)
AKR/J MGP_AKRJ_G0020825
 protein coding gene Chr13:103764575-104381027 (-)
BALB/cJ MGP_BALBcJ_G0020850
 protein coding gene Chr13:101411097-102016888 (-)
C3H/HeJ MGP_C3HHeJ_G0020639
 protein coding gene Chr13:103501907-104122115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021284
 protein coding gene Chr13:107928611-108563397 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018854
 protein coding gene Chr13:96362207-96955852 (-)
CAST/EiJ MGP_CASTEiJ_G0020158
 protein coding gene Chr13:102955663-103580246 (-)
CBA/J MGP_CBAJ_G0020601
 protein coding gene Chr13:112165537-112827710 (-)
DBA/2J MGP_DBA2J_G0020725
 protein coding gene Chr13:100465287-101070488 (-)
FVB/NJ MGP_FVBNJ_G0020707
 protein coding gene Chr13:99158632-99776995 (-)
LP/J MGP_LPJ_G0020799
 protein coding gene Chr13:104807091-105435823 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020735
 protein coding gene Chr13:112354761-112984509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021323
 protein coding gene Chr13:103236876-103865231 (-)
PWK/PhJ MGP_PWKPhJ_G0019911
 protein coding gene Chr13:99200714-99812833 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019733
 protein coding gene Chr13:99455828-100065626 (-)
WSB/EiJ MGP_WSBEiJ_G0020216
 protein coding gene Chr13:103702190-104332122 (-)



Homology
more
  • Human Ortholog
    MAST4, microtubule associated serine/threonine kinase family member 4
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAST4, microtubule associated serine/threonine kinase family member 4
  • Links
    NCBI Gene ID: 375449
    neXtProt AC: NX_O15021
    UniProt: O15021

  • Chr Location
    5q12.3; chr5:66596348-67169595 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit malocclusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    790
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034751 Ensembl Gene Model | MGI Sequence Detail 602012 C57BL/6J ±  kb
transcript ENSMUST00000167058 Ensembl | MGI Sequence Detail 10636 Not Applicable  
polypeptide ENSMUSP00000128464 Ensembl | MGI Sequence Detail 2618 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000010198 microtubule-associated serine/threonine-protein kinase 4
    (term hierarchy)
  • EC
    2.7.11.1
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
    IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
    IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
    IPR001478 PDZ domain
    IPR041489 PDZ domain 6
    IPR036034 PDZ superfamily
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 8
Other
Accession IDs
less
MGI:2145273
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:39118 Crozet F, et al., Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. 1997 Mar 1;40(2):332-41
  • Latest
    J:326767 Kim P, et al., Mast4 determines the cell fate of MSCs for bone and cartilage development. Nat Commun. 2022 Jul 8;13(1):3960
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/22/2022
MGI 6.22 		The Jackson Laboratory