Mast4 MGI Mouse Gene Detail - MGI:1918885 - microtubule associated serine/threonine kinase family member 4

Mast4 Gene Detail

Symbol

Mast4
Name

microtubule associated serine/threonine kinase family member 4
Synonyms

4930420O11Rik, mKIAA0303

Feature Type

protein coding gene
IDs

MGI:1918885
NCBI Gene: 328329

Sequence Map

Chr13:102732486-103334497 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

602012 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 54.94 cM
Mapping Data

2 experiments

Human Ortholog

MAST4, microtubule associated serine/threonine kinase family member 4

Vertebrate Orthologs

7

Human Ortholog

MAST4, microtubule associated serine/threonine kinase family member 4
Orthology source: HomoloGene, HGNC
Links

HGNC:19037

NCBI Gene ID: 375449

neXtProt AC: NX_O15021

UniProt: O15021
Chr Location

5q12.3; chr5:66596348-67169595 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 42094
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken
HCOP

human homology predictions: MAST4
Gene Tree

Mast4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Gene trapped

10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available

Mice homozygous for an ENU-induced allele exhibit malocclusion.

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All GO Annotations

15
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

84
Tissues

9
cDNA Data

13
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Mast4 interacts with 424 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

122
RefSeq

34
UniProt

10
CCDS

CCDS49349.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035371	VEGA Gene Model \| MGI Sequence Detail	602012	C57BL/6J	± kb
transcript	OTTMUST00000090372	VEGA \| MGI Sequence Detail	10636	Not Applicable
polypeptide	OTTMUSP00000049562	VEGA \| MGI Sequence Detail	2618	Not Applicable

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SNPs within 2kb

5092 from dbSNP Build 142

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UniProt

10 Sequences
Protein Ontology

PR:000010198 microtubule-associated serine/threonine-protein kinase 4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR015022 Microtubule-associated serine/threonine-protein kinase, domain

IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain

IPR001478 PDZ domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 14

cDNA 14

Microarray probesets 8

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MGI:2145273

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 4
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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