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Mast4 Gene Detail
Summary
  • Symbol
    Mast4
  • Name
    microtubule associated serine/threonine kinase family member 4
  • Synonyms
    4930420O11Rik, mKIAA0303
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918885
    NCBI Gene: 328329
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:102732486-103334497 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      602012 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 54.94 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAST4, microtubule associated serine/threonine kinase family member 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MAST4, microtubule associated serine/threonine kinase family member 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 375449
    neXtProt AC: NX_O15021
    UniProt: O15021

  • Chr Location
    5q12.3; chr5:66596348-67169595 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit malocclusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    84
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035371 VEGA Gene Model | MGI Sequence Detail 602012 C57BL/6J ±  kb
transcript OTTMUST00000090372 VEGA | MGI Sequence Detail 10636 Not Applicable  
polypeptide OTTMUSP00000049562 VEGA | MGI Sequence Detail 2618 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    5092 from dbSNP Build 142
Protein
Information
less
  • UniProt
    10 Sequences
  • EC
    2.7.11.1
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR028779 Microtubule-associated serine/threonine-protein kinase 2
    IPR037711 Microtubule-associated serine/threonine-protein kinase, catalytic domain
    IPR015022 Microtubule-associated serine/threonine-protein kinase, domain
    IPR023142 Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
    IPR001478 PDZ domain
    IPR036034 PDZ superfamily
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 8
Other
Accession IDs
less
MGI:2145273
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:39118 Crozet F, et al., Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. 1997 Mar 1;40(2):332-41
  • Latest
    J:216294 Kumar A, et al., Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Int J Dev Neurosci. 2014 Nov;38:138-46
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/11/2018
MGI 6.12 		The Jackson Laboratory