About   Help   FAQ
Scn3b
Gene Detail
Symbol

Name
ID
Scn3b
sodium channel, voltage-gated, type III, beta
MGI:1918882
Synonyms
1110001K16Rik, 4833414B02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
21.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:40269217-40291618 bp, + strand
From VEGA annotation of GRCm38

  22402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SCN3B
Protein SuperFamily: voltage-gated sodium channel, beta subunit, SCN1B/SCN3B types
Gene Tree: Scn3b

Human
homologs
SCN3B, sodium channel, voltage gated, type III beta subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55800
neXtProt AC: NX_Q9NY72

Human Synonyms: ATFB16, BRGDA7, HSA243396, SCNB3

Human Chr (Location): 11q23.3; chr11:123629187-123654607 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SCN3B

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele exhibit a ventricular arrhythmogenic phenotype with abnormal heart electrocardiography waveform features and sodium channel function.
 
Human Diseases Modeled in Mice Using Scn3b (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Scn3b interacts with 352 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process atrial cardiac muscle cell action potential, cardiac conduction, ...
Component integral component of membrane, membrane, ...
Function ion channel binding, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (266)    Tissues (51)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 261
RT-PCR 5
cDNA source data(62)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase scn3b    NEW 
Molecular
reagents
All nucleic(65) cDNA(63) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016755 (Evidence)
Ensembl Gene Model ENSMUSG00000049281 (Evidence)
Entrez Gene 235281 (Evidence)
UniGene 290083
DFCI TC1586782, TC1597113, TC1608795
DoTS DT.101358112, DT.55114646, DT.91419985
NIA Mouse Gene Index U010354
Consensus CDS Project CCDS23080.1, CCDS72214.1
International Mouse Phenotyping Consortium Status Scn3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016755 VEGA Gene Model | MGI Sequence Detail 22402 C57BL/6J ±  kb
transcript OTTMUST00000110662 VEGA | MGI Sequence Detail 4024 Not Applicable 
polypeptide OTTMUSP00000061761 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(9) UniProt(6)
Polymorphisms
SNPs within 2kb(188 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR027098 Sodium channel subunit beta-1/beta-3
InterPro IPR027096 Sodium channel subunit beta-3
Protein Ontology PR:000014524 sodium channel subunit beta-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220736 Bye CR, et al., Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1946-55
All references(43)
Disease annotation references (1)
Other
accession IDs
MGI:1915810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory