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Scn3b
Gene Detail
 Symbol
Name
ID
Scn3b
sodium channel, voltage-gated, type III, beta
MGI:1918882
Synonyms 1110001K16Rik, 4833414B02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
21.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:40269217-40291618 bp, + strand
From VEGA annotation of GRCm38

  22402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: voltage-gated sodium channel, beta subunit, SCN1B/SCN3B types
Gene Tree: Scn3b

Human
homologs
Human Homolog SCN3B, sodium channel, voltage-gated, type III, beta subunit
NCBI Gene ID 55800
neXtProt AC  NX_Q9NY72
Human Synonyms  ATFB16, BRGDA7, HSA243396, SCNB3
Human Chr (Location)  11q23.3; chr11:123629187-123654607 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SCN3B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele exhibit a ventricular arrhythmogenic phenotype with abnormal heart electrocardiography waveform features and sodium channel function.
 
Human Diseases Modeled Using Mouse Scn3b (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Scn3b interacts with 352 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process atrial cardiac muscle cell action potential, cardiac conduction, ...
Component integral component of membrane, membrane, ...
Function ion channel binding, sodium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (265)    Tissues (51)    Images (27)
Theiler Stages: 21, 22, 23, 25, 27, 28
Assay TypeResults
RNA in situ 262
RT-PCR 3
cDNA source data(62)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(64) cDNA(63) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016755 (Evidence)
Ensembl Gene ModelENSMUSG00000049281 (Evidence)
Entrez Gene235281 (Evidence)
UniGene290083
DFCITC1586782, TC1597113, TC1608795
DoTSDT.101358112, DT.55114646, DT.91419985
NIA Mouse Gene IndexU010354
Consensus CDS ProjectCCDS23080.1, CCDS72214.1
International Mouse Knockout Project StatusScn3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016755 VEGA Gene Model | MGI Sequence Detail 22402 C57BL/6J ±  kb
transcript OTTMUST00000040660 VEGA | MGI Sequence Detail 4150 Not Applicable 
polypeptide OTTMUSP00000018173 VEGA | MGI Sequence Detail 215 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(9) UniProt(6)
Polymorphisms SNPs within 2kb(188 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR027098 Sodium channel subunit beta-1/beta-3
InterPro IPR027096 Sodium channel subunit beta-3
Protein Ontology PR:000014524 sodium channel subunit beta-3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199302 Veenvliet JV, et al., Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development. 2013 Aug;140(16):3373-84
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:1915810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory