Scn3b
Gene Detail

Symbol Name ID

Scn3b sodium channel, voltage-gated, type III, beta MGI:1918882

Synonyms

1110001K16Rik, 4833414B02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

21.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:40269217-40291618 bp, + strand From VEGA annotation of GRCm38   22402 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10176  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: voltage-gated sodium channel, beta subunit, SCN1B/SCN3B types
Gene Tree: Scn3b

Human homologs

Human Homolog		SCN3B, sodium channel, voltage-gated, type III, beta subunit
NCBI Gene ID		55800
neXtProt AC		NX_Q9NY72
Human Synonyms		HSA243396, SCNB3
Human Chr (Location)		11q23.3; chr11:123499895-123525315 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SCN3B

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit a ventricular arrhythmogenic phenotype with abnormal heart electrocardiography waveform features and sodium channel function.

 
Human Diseases Modeled Using Mouse Scn3b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cardiac conduction, cardiac muscle contraction, ...
Component	integral to membrane, membrane, ...
Function	ion channel activity, ion channel binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (265)    Tissues (50)    Images (27)
Theiler Stages: 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	262
RT-PCR	3

cDNA source data(62)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(64) cDNA(63) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016755 (Evidence)
Ensembl Gene Model	ENSMUSG00000049281 (Evidence)
Entrez Gene	235281 (Evidence)
UniGene	290083
DFCI	TC1586782, TC1597113, TC1608795
DoTS	DT.101358112, DT.55114646, DT.91419985
NIA Mouse Gene Index	U010354
Consensus CDS Project	CCDS23080.1
International Mouse Knockout Project Status	Scn3b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016755	VEGA Gene Model | MGI Sequence Detail	22402	C57BL/6J
transcript	OTTMUST00000110662	VEGA | MGI Sequence Detail	4024	Not Applicable
polypeptide	OTTMUSP00000061761	VEGA | MGI Sequence Detail	215	Not Applicable

All sequences(63) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(156 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000014524	sodium channel subunit beta-3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Other accession IDs

MGI:1915810