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Arhgap42 Gene Detail
Summary
  • Symbol
    Arhgap42
  • Name
    Rho GTPase activating protein 42
  • Synonyms
    9030420J04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918794
    NCBI Gene: 71544
Location & Maps
more
  • Sequence Map
    Chr9:8994329-9239101 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      244773 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARHGAP42, Rho GTPase activating protein 42
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP42, Rho GTPase activating protein 42
    Orthology source: HomoloGene
  • Synonyms
    GRAF3
  • Links
    NCBI Gene ID: 143872
    neXtProt AC: NX_A6NI28

  • Chr Location
    11q22.1; chr11:100687676-100990925 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit hypertension and increased vascular smooth muscle contractility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043543 VEGA Gene Model | MGI Sequence Detail 244773 C57BL/6J ±  kb
transcript OTTMUST00000114235 VEGA | MGI Sequence Detail 6116 Not Applicable  
polypeptide OTTMUSP00000063767 VEGA | MGI Sequence Detail 841 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1288 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 5
Other
Accession IDs
less
MGI:3034272
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:221301 Bai X, et al., The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nat Commun. 2013;4:2910

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory