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Piezo2 Gene Detail
Summary
  • Symbol
    Piezo2
  • Name
    piezo-type mechanosensitive ion channel component 2
  • Synonyms
    9030411M15Rik, 9430028L06Rik, Fam38b, Fam38b2, Piezo2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918781
    NCBI Gene: 667742
  • Gene Overview
    MyGene.info: PIEZO2
Location & Maps
more
  • Sequence Map
    Chr18:63010213-63387183 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      376971 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 35.95 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PIEZO2, piezo type mechanosensitive ion channel component 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIEZO2, piezo type mechanosensitive ion channel component 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C18orf30, C18orf58, DA3, DA5, FAM38B, FAM38B2, HsT748, HsT771, MWKS
  • Links
    NCBI Gene ID: 63895
    neXtProt AC: NX_Q9H5I5

  • Chr Location
    18p11.22; chr18:10670134-11148762 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human PIEZO2 associations

Human Disease Mouse Models
       Arthrogryposis, Distal, Type 3; DA3   OMIM: 114300
Arthrogryposis, Distal, Type 5; DA5   OMIM: 108145
Marden-Walker Syndrome; MWKS   OMIM: 248700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    5 phenotype references
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase piezo2
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028308 VEGA Gene Model | MGI Sequence Detail 376971 C57BL/6J ±  kb
transcript OTTMUST00000070148 VEGA | MGI Sequence Detail 10724 Not Applicable  
polypeptide OTTMUSP00000035722 VEGA | MGI Sequence Detail 2824 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2889 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000032708 piezo-type mechanosensitive ion channel component 2
  • InterPro Domains
    IPR031805 Piezo domain
    IPR027272 Piezo family
    IPR031334 Piezo non-specific cation channel, R-Ras-binding domain
Molecular
Reagents
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  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2442541
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:219613 Schrenk-Siemens K, et al., PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Nat Neurosci. 2015 Jan;18(1):10-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory