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Gas2l3 Gene Detail
Summary
  • Symbol
    Gas2l3
  • Name
    growth arrest-specific 2 like 3
  • Synonyms
    8430435B07Rik, LOC237436
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918780
    NCBI Gene: 237436
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:89408823-89443967 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 44.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918780
protein coding gene Chr10:89408822-89444374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017635
protein coding gene Chr10:90567699-90610884 (-)
A/J MGP_AJ_G0017614
protein coding gene Chr10:87479118-87513957 (-)
AKR/J MGP_AKRJ_G0017572
protein coding gene Chr10:89971406-90008253 (-)
BALB/cJ MGP_BALBcJ_G0017577
protein coding gene Chr10:87750958-87785571 (-)
C3H/HeJ MGP_C3HHeJ_G0017400
protein coding gene Chr10:89976567-90015655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018034
protein coding gene Chr10:93607553-93650425 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015716
protein coding gene Chr10:83206179-83241517 (-)
CAST/EiJ MGP_CASTEiJ_G0016965
protein coding gene Chr10:89892574-89930197 (-)
CBA/J MGP_CBAJ_G0017369
protein coding gene Chr10:97474951-97511925 (-)
DBA/2J MGP_DBA2J_G0017475
protein coding gene Chr10:86615703-86651011 (-)
FVB/NJ MGP_FVBNJ_G0017467
protein coding gene Chr10:85817237-85851934 (-)
LP/J MGP_LPJ_G0017549
protein coding gene Chr10:91225003-91262989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017498
protein coding gene Chr10:98958474-98997096 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018071
protein coding gene Chr10:89843108-89879158 (-)
PWK/PhJ MGP_PWKPhJ_G0016746
protein coding gene Chr10:86637259-86674439 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016534
protein coding gene Chr10:88621749-88658524 (-)
WSB/EiJ MGP_WSBEiJ_G0017024
protein coding gene Chr10:89848011-89885940 (-)



Homology
more
  • Human Ortholog
    GAS2L3, growth arrest specific 2 like 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GAS2L3, growth arrest specific 2 like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G2L3
  • Links
    NCBI Gene ID: 283431
    neXtProt AC: NX_Q86XJ1
    UniProt: Q86XJ1

  • Chr Location
    12q23.1; chr12:100573661-100628288 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial postnatal lethality with none surviving past 4 months, dilated cardiomyopathy, cardiac interstitial fibrosis, and premature binucleation of cardiomyocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074802 Ensembl Gene Model | MGI Sequence Detail 35145 C57BL/6J ±  kb
transcript ENSMUST00000105298 Ensembl | MGI Sequence Detail 6305 Not Applicable  
polypeptide ENSMUSP00000100935 Ensembl | MGI Sequence Detail 683 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 54

    Microarray probesets 5
Other
Accession IDs
less
MGI:2685086
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:270210 Loo L, et al., Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun. 2019 Jan 11;10(1):134

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory