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Pds5a Gene Detail
Summary
  • Symbol
    Pds5a
  • Name
    PDS5 cohesin associated factor A
  • Synonyms
    9030416H16Rik, E230024D05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918771
    NCBI Gene: 71521
  • Gene Overview
    MyGene.info: PDS5A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65607777-65698163 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.76 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918771
protein coding gene Chr5:65605721-65698273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029582
protein coding gene Chr5:65264961-65387009 (-)
A/J MGP_AJ_G0029550
protein coding gene Chr5:62830324-62922807 (-)
AKR/J MGP_AKRJ_G0029498
protein coding gene Chr5:64829873-64934528 (-)
BALB/cJ MGP_BALBcJ_G0029559
protein coding gene Chr5:63520314-63616658 (-)
C3H/HeJ MGP_C3HHeJ_G0029282
protein coding gene Chr5:65169131-65272065 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030013
protein coding gene Chr5:67954563-68061334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027253
protein coding gene Chr5:58904781-58996385 (-)
CAST/EiJ MGP_CASTEiJ_G0028690
protein coding gene Chr5:64270386-64368987 (-)
CBA/J MGP_CBAJ_G0029251
protein coding gene Chr5:70162945-70270912 (-)
DBA/2J MGP_DBA2J_G0029397
protein coding gene Chr5:62868667-62965082 (-)
FVB/NJ MGP_FVBNJ_G0029357
protein coding gene Chr5:62037091-62131130 (-)
LP/J MGP_LPJ_G0029482
protein coding gene Chr5:65770393-65872226 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029385
protein coding gene Chr5:73030772-73135968 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030046
protein coding gene Chr5:64500614-64597685 (-)
PWK/PhJ MGP_PWKPhJ_G0028414
protein coding gene Chr5:61842431-61934157 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028248
protein coding gene Chr5:63836907-63938081 (-)
WSB/EiJ MGP_WSBEiJ_G0028770
protein coding gene Chr5:64708915-64810312 (-)



Homology
more
  • Human Ortholog
    PDS5A, PDS5 cohesin associated factor A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PDS5A, PDS5 cohesin associated factor A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PIG54, SCC112, SCC-112
  • Links
    NCBI Gene ID: 23244
    neXtProt AC: NX_Q29RF7
    UniProt: Q29RF7

  • Chr Location
    4p14; chr4:39822863-39977956 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Pds5a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    3 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, abnormal heart development, abnormal skeletal development, kidney agenesis, and delayed enteric nervous system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71521 NCBI Gene Model | MGI Sequence Detail 90387 C57BL/6J ±  kb
    transcript NM_001081321 RefSeq | MGI Sequence Detail 6687 C57BL/6  
    polypeptide NP_001074790 RefSeq | MGI Sequence Detail 1332 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2442025
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 3
      Phenotypes 25
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:205601 Carretero M, et al., Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 2013 Nov 13;32(22):2938-49

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory