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Pds5a Gene Detail
Summary
  • Symbol
    Pds5a
  • Name
    PDS5 cohesin associated factor A
  • Synonyms
    9030416H16Rik, E230024D05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918771
    NCBI Gene: 71521
  • Gene Overview
    MyGene.info: PDS5A
Location & Maps
more
  • Sequence Map
    Chr5:65605721-65698273 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.76 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDS5A, PDS5 cohesin associated factor A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PDS5A, PDS5 cohesin associated factor A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PIG54, SCC112, SCC-112
  • Links
    NCBI Gene ID: 23244
    neXtProt AC: NX_Q29RF7

  • Chr Location
    4p14; chr4:39822863-39977956 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    3 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Chemically induced (other)
    2
  • Gene trapped
    55
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Pds5a
  • Incidental Mutations
Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, abnormal heart development, abnormal skeletal development, kidney agenesis, and delayed enteric nervous system development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055174 VEGA Gene Model | MGI Sequence Detail 92553 C57BL/6J ±  kb
transcript OTTMUST00000136635 VEGA | MGI Sequence Detail 8934 Not Applicable  
polypeptide OTTMUSP00000072091 VEGA | MGI Sequence Detail 1332 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    264 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012519 sister chromatid cohesion protein PDS5 homolog A
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2442025
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 25
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205601 Carretero M, et al., Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 2013 Nov 13;32(22):2938-49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory