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Pds5a
Gene Detail
 Symbol
Name
ID
Pds5a
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
MGI:1918771
Synonyms 9030416H16Rik, E230024D05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 5
33.76 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:65615260-65697856 bp, - strand
From NCBI annotation of GRCm38

  82597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22877  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pds5a

Human
homologs
Human Homolog PDS5A, PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
NCBI Gene ID 23244
neXtProt AC  NX_Q29RF7
Human Synonyms  SCC112, SCC-112
Human Chr (Location)  4p14; chr4:39822863-39977956 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(56) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, abnormal heart development, abnormal skeletal development, kidney agenesis, and delayed enteric nervous system development.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process mitotic sister chromatid cohesion, negative regulation of DNA replication
Component chromatin, nucleus, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (284)    Tissues (108)    Images (47)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 284
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000029202 (Evidence)
Entrez Gene71521 (Evidence)
DFCITC1582221, TC1594538, TC1604002, TC1648205
DoTSDT.40165503, DT.94183379, DT.94183380, DT.97366728, DT.99855085
Consensus CDS ProjectCCDS39099.1
International Mouse Knockout Project StatusPds5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 71521 NCBI Gene Model | MGI Sequence Detail 82597 C57BL/6J ±  kb
transcript NM_001081321 RefSeq | MGI Sequence Detail 4146 Not Specified 
polypeptide NP_001074790 RefSeq | MGI Sequence Detail 1332 Not Specified 

For the selected sequences
All sequences(38) RefSeq(14) UniProt(4)
Polymorphisms SNPs within 2kb(224 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000012519 sister chromatid cohesion protein PDS5 homolog A
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205601 Carretero M, et al., Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres. EMBO J. 2013 Nov 13;32(22):2938-49
All references(31)
Other
accession IDs
MGI:2442025

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory