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Grap Gene Detail
Summary
  • Symbol
    Grap
  • Name
    GRB2-related adaptor protein
  • Synonyms
    8430435N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918770
    NCBI Gene: 71520
  • Gene Overview
    MyGene.info: GRAP
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:61653321-61672777 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918770
protein coding gene Chr11:61653265-61672784 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018443
protein coding gene Chr11:61626304-61645368 (+)
A/J MGP_AJ_G0018412
protein coding gene Chr11:59352950-59372418 (+)
AKR/J MGP_AKRJ_G0018382
protein coding gene Chr11:61194746-61213649 (+)
BALB/cJ MGP_BALBcJ_G0018383
protein coding gene Chr11:59654457-59674712 (+)
C3H/HeJ MGP_C3HHeJ_G0018196
protein coding gene Chr11:61177611-61199296 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018835
protein coding gene Chr11:63582531-63606779 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016481
protein coding gene Chr11:56469299-56488537 (+)
CAST/EiJ MGP_CASTEiJ_G0017753
protein coding gene Chr11:61284139-61303467 (+)
CBA/J MGP_CBAJ_G0018170
protein coding gene Chr11:66340539-66367220 (+)
DBA/2J MGP_DBA2J_G0018279
protein coding gene Chr11:58921503-58941442 (+)
FVB/NJ MGP_FVBNJ_G0018270
protein coding gene Chr11:58606343-58625564 (+)
LP/J MGP_LPJ_G0018352
protein coding gene Chr11:62198892-62217972 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018294
protein coding gene Chr11:67340267-67359171 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018876
protein coding gene Chr11:61331121-61351827 (+)
PWK/PhJ MGP_PWKPhJ_G0017526
protein coding gene Chr11:59527586-59547115 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017316
protein coding gene Chr11:61158470-61178376 (+)
WSB/EiJ MGP_WSBEiJ_G0017805
protein coding gene Chr11:60940634-60959608 (+)



Homology
more
  • Human Ortholog
    GRAP, GRB2 related adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRAP, GRB2 related adaptor protein
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 10750
    neXtProt AC: NX_Q13588
    UniProt: Q13588

  • Chr Location
    17p11.2; chr17:19020656-19051352 (-)  GRCh38.p7

  • Human Ortholog
    GRAPL, GRB2 related adaptor protein like
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 400581
    neXtProt AC: NX_Q8TC17
    UniProt: Q8TC17

  • Chr Location
    17p11.2; chr17:19123188-19159187 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a greater proliferative T cell response to TCR stimulation. In all other respects, they are normal.
Gene Ontology
(GO)
Classifications
less
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 71520 NCBI Gene Model | MGI Sequence Detail 19457 C57BL/6J ±  kb
transcript NM_027817 RefSeq | MGI Sequence Detail 1599 C57BL/6  
polypeptide Q9CX99 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 2
    cDNA 13

    Microarray probesets 2
Other
Accession IDs
less
MGI:2144614
References
more
  • Summaries
    All 25
    Phenotypes 6
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory