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Grap Gene Detail
Summary
  • Symbol
    Grap
  • Name
    GRB2-related adaptor protein
  • Synonyms
    8430435N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918770
    NCBI Gene: 71520
Location & Maps
more
  • Sequence Map
    Chr11:61653265-61672784 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19520 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GRAP, GRB2-related adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRAP, GRB2-related adaptor protein
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 10750
    neXtProt AC: NX_Q13588

  • Chr Location
    17p11.2; chr17:19020677-19047023 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4822
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: GRAP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Grap
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a greater proliferative T cell response to TCR stimulation. In all other respects, they are normal.
Gene Ontology
(GO)
Classifications
less
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005843 VEGA Gene Model | MGI Sequence Detail 19520 C57BL/6J ±  kb
transcript OTTMUST00000012997 VEGA | MGI Sequence Detail 1662 Not Applicable  
polypeptide OTTMUSP00000006043 VEGA | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    183 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 13

    Microarray probesets 2
Other
Accession IDs
less
MGI:2144614
References
more
  • Summaries
    All 23
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory