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Grap
Gene Detail
Symbol

Name
ID
Grap
GRB2-related adaptor protein
MGI:1918770
Synonyms
8430435N19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.96 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:61653265-61672784 bp, + strand
From VEGA annotation of GRCm38

  19520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GRAP
Gene Tree: Grap

Human
homologs
GRAP, GRB2-related adaptor protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10750
neXtProt AC: NX_Q13588

Human Chr (Location): 17p11.2; chr17:19020677-19047023 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display a greater proliferative T cell response to TCR stimulation. In all other respects, they are normal.
 
Interactions
Grap interacts with 99 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process biological_process
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100127598 ; ZFIN grapa    NEW 
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000005843 (Evidence)
Ensembl Gene Model ENSMUSG00000004837 (Evidence)
Entrez Gene 71520 (Evidence)
UniGene 202760
DFCI TC1582801, TC1728170
DoTS DT.94233790, DT.101371203, DT.55273993
Consensus CDS Project CCDS24817.1
International Mouse Phenotyping Consortium Status Grap
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005843 VEGA Gene Model | MGI Sequence Detail 19520 C57BL/6J ±  kb
transcript OTTMUST00000012997 VEGA | MGI Sequence Detail 1662 Not Applicable 
polypeptide OTTMUSP00000006043 VEGA | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000008219 GRB2-related adapter protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)
Other
accession IDs
MGI:2144614

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory