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Sfpq
Gene Detail
Symbol

Name
ID
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
MGI:1918764
Synonyms
1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, D4Ertd314e, PSF, REP1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
61.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:127021324-127037013 bp, + strand
From VEGA annotation of GRCm38

  15690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SFPQ
Gene Tree: Sfpq

Human
homologs
SFPQ, splicing factor proline/glutamine-rich
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6421
neXtProt AC: NX_P23246

Human Synonyms: POMP100, PPP1R140, PSF

Human Chr (Location): 1p34.3; chr1:35176380-35193158 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Genomic Mutations involving Sfpq (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele die. Heterozygous mice show abnormality in entrainment of circadian rhythm.
 
Interactions
Sfpq interacts with 268 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process alternative mRNA splicing, via spliceosome, cellular response to DNA damage stimulus, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (29)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
RT-PCR 2
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sfpq ; ZFIN sfpq    NEW 
Molecular
reagents
All nucleic(29) cDNA(27) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000009316 (Evidence)
Ensembl Gene Model ENSMUSG00000028820 (Evidence)
Entrez Gene 71514 (Evidence)
Consensus CDS Project CCDS18662.1
International Mouse Phenotyping Consortium Status Sfpq
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009316 VEGA Gene Model | MGI Sequence Detail 15690 C57BL/6J ±  kb
transcript OTTMUST00000021160 VEGA | MGI Sequence Detail 3465 Not Applicable 
polypeptide OTTMUSP00000009684 VEGA | MGI Sequence Detail 699 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012975 NOPS
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000014743 splicing factor, proline- and glutamine-rich
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:218440 Wang T, et al., Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015 Jan;36(1):527-35
All references(52)
Other
accession IDs
MGI:1196226, MGI:1915728, MGI:1917845, MGI:1925565, MGI:2140463

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory