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Sfpq Gene Detail
Summary
  • Symbol
    Sfpq
  • Name
    splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
  • Synonyms
    1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, D4Ertd314e, PSF, REP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918764
    NCBI Gene: 71514
  • Gene Overview
    MyGene.info: SFPQ
Location & Maps
more
  • Sequence Map
    Chr4:127021324-127037013 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15690 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 61.20 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SFPQ, splicing factor proline and glutamine rich
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SFPQ, splicing factor proline and glutamine rich
    Orthology source: HomoloGene
  • Synonyms
    POMP100, PPP1R140, PSF
  • Links
    NCBI Gene ID: 6421
    neXtProt AC: NX_P23246

  • Chr Location
    1p34.3; chr1:35176380-35193158 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Sfpq
  • Incidental Mutations
Mice homozygous for a gene trap allele die. Heterozygous mice show abnormality in entrainment of circadian rhythm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009316 VEGA Gene Model | MGI Sequence Detail 15690 C57BL/6J ±  kb
transcript OTTMUST00000021160 VEGA | MGI Sequence Detail 3465 Not Applicable  
polypeptide OTTMUSP00000009684 VEGA | MGI Sequence Detail 699 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014743 splicing factor, proline- and glutamine-rich
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 29
    cDNA 27
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGI:1196226, MGI:1915728, MGI:1917845, MGI:1925565, MGI:2140463
References
more
  • Summaries
    All 54
    Developmental Gene Expression 5
    Gene Ontology 14
    Phenotypes 16
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:218440 Wang T, et al., Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015 Jan;36(1):527-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory