Sfpq
Gene Detail

Symbol Name ID

Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) MGI:1918764

Synonyms

1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, D4Ertd314e, PSF, REP1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

61.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:127021324-127037013 bp, + strand From VEGA annotation of GRCm38   15690 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3714  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sfpq

Human homologs

Human Homolog		SFPQ, splicing factor proline/glutamine-rich
NCBI Gene ID		6421
neXtProt AC		NX_P23246
Human Synonyms		POMP100, PSF
Human Chr (Location)		1p34.3; chr1:35649201-35658743 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(2) Gene trapped(15)
 

Mice homozygous for a gene trap allele die. Heterozygous mice show abnormality in entrainment of circadian rhythm.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	alternative mRNA splicing, via spliceosome, DNA repair, ...
Component	cytoplasm, nuclear matrix, ...
Function	DNA binding, nucleic acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (29)    Images (8)
Theiler Stages: 11, 13, 19, 21, 28

Assay Type	Results
RNA in situ	29
RT-PCR	2

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) cDNA(27) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000009316 (Evidence)
Ensembl Gene Model	ENSMUSG00000028820 (Evidence)
Entrez Gene	71514 (Evidence)
Consensus CDS Project	CCDS18662.1
International Mouse Knockout Project Status	Sfpq

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009316	VEGA Gene Model | MGI Sequence Detail	15690	C57BL/6J
transcript	OTTMUST00000021160	VEGA | MGI Sequence Detail	3465	Not Applicable
polypeptide	OTTMUSP00000009684	VEGA | MGI Sequence Detail	699	Not Applicable

All sequences(74) RefSeq(3) UniProt(5)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012975	NOPS
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000014743	splicing factor, proline- and glutamine-rich

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:189236 Kowalska E, et al., Distinct Roles of DBHS Family Members in the Circadian Transcriptional Feedback Loop. Mol Cell Biol. 2012 Nov;32(22):4585-94
All references(44)

Other accession IDs

MGI:1196226, MGI:1915728, MGI:1917845, MGI:1925565, MGI:2140463