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Alpk1 Gene Detail
Summary
  • Symbol
    Alpk1
  • Name
    alpha-kinase 1
  • Synonyms
    8430410J10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918731
    NCBI Gene: 71481
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127463959-127574176 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3331 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918731
 protein coding gene Chr3:127460367-127574195 (-)
129S1/SvImJ ENSMUSG00200002679
 protein coding gene Chr3:124207890-124309239 (-)
A/J ENSMUSG00195007889
 protein coding gene Chr3:124346623-124447985 (-)
AKR/J ENSMUSG00220021861
 protein coding gene Chr3:122778460-122888839 (-)
BALB/cJ ENSMUSG00180003451
 protein coding gene Chr3:124273754-124375114 (-)
C3H/HeJ ENSMUSG00175012372
 protein coding gene Chr3:123827433-123928793 (-)
C57BL/6NJ ENSMUSG00215017140
 protein coding gene Chr3:124609351-124719718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025617
 protein coding gene Chr3:120965939-121070224 (-)
CAST/EiJ ENSTCUG00005003587
 protein coding gene Chr3:124914035-125017719 (-)
CBA/J ENSMUSG00210003376
 protein coding gene Chr3:124450656-124551995 (-)
DBA/2J ENSMUSG00185025503
 protein coding gene Chr3:125062260-125172609 (-)
FVB/NJ ENSMUSG00205021890
 protein coding gene Chr3:123407366-123518166 (-)
JF1/MsJ ENSUMUG00000026020
 protein coding gene Chr3:123818955-123920392 (-)
LP/J ENSMUSG00230002680
 protein coding gene Chr3:127039571-127151815 (-)
NOD/ShiLtJ ENSMUSG00190001439
 protein coding gene Chr3:125457514-125567948 (-)
NZO/HlLtJ ENSMUSG00225002205
 protein coding gene Chr3:129496942-129607288 (-)
PWK/PhJ ENSLUMG00010015197
 protein coding gene Chr3:123840226-123941765 (-)
SPRET/EiJ ENSMSPG00010012202
 protein coding gene Chr3:124757111-124862393 (-)
WSB/EiJ ENSIUOG00005015856
 protein coding gene Chr3:124626103-124736954 (-)



Homology
more
  • Human Ortholog
    ALPK1, alpha kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALPK1, alpha kinase 1
  • Synonyms
    8430410J10Rik, LAK, ROSAH
  • Links
    NCBI Gene ID: 80216
    UniProt: Q96QP1

  • Chr Location
    4q25; chr4:112285509-112442621 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    15 phenotype references
Homozygosity for the p.T237M mutation leads to increased levels of certain chemokines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028028 Ensembl Gene Model | MGI Sequence Detail 110218 C57BL/6J ±  kb
transcript ENSMUST00000198955 Ensembl | MGI Sequence Detail 4498 Not Applicable  
polypeptide ENSMUSP00000143223 Ensembl | MGI Sequence Detail 1231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 5
References
more
  • Summaries
    All 50
    Diseases 1
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:372687 Agarwal P, et al., Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1. Nature. 2025 Jun;642(8066):201-211
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory