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Alpk1 Gene Detail
Summary
  • Symbol
    Alpk1
  • Name
    alpha-kinase 1
  • Synonyms
    8430410J10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918731
    NCBI Gene: 71481
  • Gene Overview
    MyGene.info: ALPK1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127670310-127780527 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1422 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918731
protein coding gene Chr3:127670308-127780553 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027864
protein coding gene Chr3:130178866-130289717 (-)
A/J MGP_AJ_G0027822
protein coding gene Chr3:125720306-125821463 (-)
AKR/J MGP_AKRJ_G0027787
protein coding gene Chr3:128969352-129079578 (-)
BALB/cJ MGP_BALBcJ_G0027835
protein coding gene Chr3:125581621-125685607 (-)
C3H/HeJ MGP_C3HHeJ_G0027564
protein coding gene Chr3:129348452-129452708 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028279
protein coding gene Chr3:134875645-134988341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025617
protein coding gene Chr3:120965939-121070224 (-)
CAST/EiJ MGP_CASTEiJ_G0027021
protein coding gene Chr3:128914334-129025434 (-)
CBA/J MGP_CBAJ_G0027540
protein coding gene Chr3:139434890-139554820 (-)
DBA/2J MGP_DBA2J_G0027681
protein coding gene Chr3:124936351-125041470 (-)
FVB/NJ MGP_FVBNJ_G0027648
protein coding gene Chr3:122505961-122626871 (-)
LP/J MGP_LPJ_G0027790
protein coding gene Chr3:131726492-131837017 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027679
protein coding gene Chr3:147354097-147485982 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028336
protein coding gene Chr3:128605385-128720632 (-)
PWK/PhJ MGP_PWKPhJ_G0026745
protein coding gene Chr3:124670990-124773009 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026570
protein coding gene Chr3:126690614-126802296 (-)
WSB/EiJ MGP_WSBEiJ_G0027100
protein coding gene Chr3:129330411-129440525 (-)



Homology
more
  • Human Ortholog
    ALPK1, alpha kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALPK1, alpha kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    8430410J10Rik, LAK
  • Links
    NCBI Gene ID: 80216
    neXtProt AC: NX_Q96QP1
    UniProt: Q96QP1

  • Chr Location
    4q25; chr4:112286420-112442618 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028028 Ensembl Gene Model | MGI Sequence Detail 110218 C57BL/6J ±  kb
transcript ENSMUST00000198955 Ensembl | MGI Sequence Detail 4498 Not Applicable  
polypeptide ENSMUSP00000143223 Ensembl | MGI Sequence Detail 1231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 5
References
more
  • Summaries
    All 27
    Diseases 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:264436 Zhou P, et al., Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature. 2018 Aug 15;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory