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Ptk7 Gene Detail
Summary
  • Symbol
    Ptk7
  • Name
    PTK7 protein tyrosine kinase 7
  • Synonyms
    8430404F20Rik, chz, mPTK7/CCK4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918711
    NCBI Gene: 71461
  • Gene Overview
    MyGene.info: PTK7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:46564451-46629504 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65054 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband B3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PTK7, protein tyrosine kinase 7 (inactive)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTK7, protein tyrosine kinase 7 (inactive)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCK4, CCK-4
  • Links
    NCBI Gene ID: 5754
    neXtProt AC: NX_Q13308
    UniProt: Q13308

  • Chr Location
    6p21.1; chr6:43076268-43161720 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 43672
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PTK7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die perinatally with defects in neural tube closure and planar cell polarity in the ear. ENU-induced mutant mice show omphalocele, impaired neural tube, heart and lung development, rib defects, polydactyly, failed eyelid closure and altered cell polarity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023972 Ensembl Gene Model | MGI Sequence Detail 65054 C57BL/6J ±  kb
    transcript ENSMUST00000044442 Ensembl | MGI Sequence Detail 4255 Not Applicable  
    polypeptide ENSMUSP00000043703 Ensembl | MGI Sequence Detail 1062 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      310 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 64
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3640801
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263062 Xu B, et al., Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis. Dev Biol. 2018 Jun 1;438(1):33-43

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory