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Bcor
Gene Detail
Symbol

Name
ID
Bcor
BCL6 interacting corepressor
MGI:1918708
Synonyms
5830466J11Rik, 8430401K06Rik, D930024N20Rik, mKIAA1575
Feature Type
protein coding gene
Genetic Map
Chromosome X
6.83 cM, cytoband A1.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:12036740-12160355 bp, - strand
From VEGA annotation of GRCm38

  123616 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9809  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BCOR
Gene Tree: Bcor

Human
homologs
BCOR, BCL6 corepressor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 54880
neXtProt AC: NX_Q6W2J9

Human Synonyms: ANOP2, MAA2, MCOPS2

Human Chr (Location): Xp11.4; chrX:40051246-40177390 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human BCOR

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(26) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Male chimeras hemizygous for either of two different gene trapped alleles die by E9.5 exhibiting anomalies in somite formation and heart looping, forebrain fusion, and microcephaly. Hemizygosity for other gene trapped alleles can cause patterning and embryo turning defects or abnormal gastrulation.
 
Phenotype Images(24)
Interactions
Bcor interacts with 270 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process chromatin modification, heart development, ...
Component nucleus, PcG protein complex
Function heat shock protein binding, histone deacetylase binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (242)    Tissues (101)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
Northern blot 4
RT-PCR 88
cDNA source data(106)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bcor    NEW 
Molecular
reagents
All nucleic(112) cDNA(107) Primer pair(5)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016940 (Evidence)
Ensembl Gene Model ENSMUSG00000040363 (Evidence)
Entrez Gene 71458 (Evidence)
UniGene 196328
DFCI TC1576378, TC1590514, TC1592974
DoTS DT.99854036, DT.103566839, DT.101737539, DT.99854034, DT.60103667
NIA Mouse Gene Index U039264
Consensus CDS Project CCDS30021.1, CCDS30022.1, CCDS40872.1, CCDS40873.1
International Mouse Phenotyping Consortium Status Bcor
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016940 VEGA Gene Model | MGI Sequence Detail 123616 C57BL/6J ±  kb
transcript OTTMUST00000041082 VEGA | MGI Sequence Detail 6941 Not Applicable 
polypeptide OTTMUSP00000018407 VEGA | MGI Sequence Detail 1759 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000004709 BCL-6 corepressor
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218799 Yoon J, et al., Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR. J Biol Chem. 2014 Dec 5;289(49):34250-7
All references(41)
Other
accession IDs
MGI:1923325, MGI:2444213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory