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Bcor Gene Detail
Summary
  • Symbol
    Bcor
  • Name
    BCL6 interacting corepressor
  • Synonyms
    5830466J11Rik, 8430401K06Rik, D930024N20Rik, mKIAA1575
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918708
    NCBI Gene: 71458
Location & Maps
more
  • Sequence Map
    ChrX:12036740-12160355 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123616 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    BCOR, BCL6 corepressor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCOR, BCL6 corepressor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANOP2, MAA2, MCOPS2
  • Links
    NCBI Gene ID: 54880
    neXtProt AC: NX_Q6W2J9

  • Chr Location
    Xp11.4; chrX:40051246-40177390 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9809
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BCOR
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human BCOR associations

Human Disease Mouse Models
       Microphthalmia, Syndromic 1; MCOPS1   OMIM: 309800
Microphthalmia, Syndromic 2; MCOPS2   OMIM: 300166
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 5 alleles in 3 genetic backgrounds
    24 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for either of two different gene trapped alleles die by E9.5 exhibiting anomalies in somite formation and heart looping, forebrain fusion, and microcephaly. Hemizygosity for other gene trapped alleles can cause patterning and embryo turning defects or abnormal gastrulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016940 VEGA Gene Model | MGI Sequence Detail 123616 C57BL/6J ±  kb
transcript OTTMUST00000041082 VEGA | MGI Sequence Detail 6941 Not Applicable  
polypeptide OTTMUSP00000018407 VEGA | MGI Sequence Detail 1759 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    177 from dbSNP Build 137
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004709 BCL-6 corepressor
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR031628 BCL-6 corepressor, non-ankyrin-repeat domain
    IPR032365 BCL-6 corepressor, PCGF1 binding domain
Molecular
Reagents
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  • All nucleic 112
    cDNA 107
    Primer pair 5

    Microarray probesets 5
Other
Accession IDs
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MGI:1923325, MGI:2444213
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:218799 Yoon J, et al., Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR. J Biol Chem. 2014 Dec 5;289(49):34250-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory