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Flrt3 Gene Detail
Summary
  • Symbol
    Flrt3
  • Name
    fibronectin leucine rich transmembrane protein 3
  • Synonyms
    5530600M07Rik, C430047I10Rik, mKIAA1469
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918686
    NCBI Gene: 71436
  • Gene Overview
    MyGene.info: FLRT3
Location & Maps
more
  • Sequence Map
    Chr2:140650914-140671469 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      20556 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 69.20 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FLRT3, fibronectin leucine rich transmembrane protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLRT3, fibronectin leucine rich transmembrane protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH21
  • Links
    NCBI Gene ID: 23767
    neXtProt AC: NX_Q9NZU0

  • Chr Location
    20p11; chr20:14323993-14337667 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 8322
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FLRT3
  • Gene Tree
    Flrt3
Human Diseases
more
  • Diseases
    1 with human FLRT3 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 21 with or without Anosmia; HH21   OMIM: 615271
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 4 alleles in 6 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Flrt3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, abnormal embryonic tissue development, disrupted head formation, cardia bifida and abnormal ventral wall closure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    291
  • Tissues
    86
  • cDNA Data
    16
  • Literature Summary
    14
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015600 VEGA Gene Model | MGI Sequence Detail 20556 C57BL/6J ±  kb
transcript OTTMUST00000037050 VEGA | MGI Sequence Detail 3977 Not Applicable  
polypeptide OTTMUSP00000016617 VEGA | MGI Sequence Detail 649 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    157 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007562 leucine-rich repeat transmembrane protein FLRT3
  • PDB
    4V2E, 4YEB
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR003961 Fibronectin type III
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 1
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1924899
References
more
  • Summaries
    All 48
    Developmental Gene Expression 14
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224719 Leyva-Diaz E, et al., FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Curr Biol. 2014 Mar 3;24(5):494-508
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory