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Flrt3 Gene Detail
Summary
  • Symbol
    Flrt3
  • Name
    fibronectin leucine rich transmembrane protein 3
  • Synonyms
    5530600M07Rik, C430047I10Rik, mKIAA1469
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918686
    NCBI Gene: 71436
  • Gene Overview
    MyGene.info: FLRT3
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:140658198-140671476 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 69.20 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918686
 protein coding gene Chr2:140650914-140671476 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026572
 protein coding gene Chr2:144594245-144614799 (-)
A/J MGP_AJ_G0026536
 protein coding gene Chr2:138739878-138760422 (-)
AKR/J MGP_AKRJ_G0026510
 protein coding gene Chr2:142722338-142742882 (-)
BALB/cJ MGP_BALBcJ_G0026548
 protein coding gene Chr2:139164009-139184549 (-)
C3H/HeJ MGP_C3HHeJ_G0026291
 protein coding gene Chr2:143241182-143261727 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026993
 protein coding gene Chr2:148946916-148968666 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024369
 protein coding gene Chr2:133049744-133071008 (-)
CAST/EiJ MGP_CASTEiJ_G0025752
 protein coding gene Chr2:143553440-143573796 (-)
CBA/J MGP_CBAJ_G0026271
 protein coding gene Chr2:154383143-154404468 (-)
DBA/2J MGP_DBA2J_G0026405
 protein coding gene Chr2:138087657-138108193 (-)
FVB/NJ MGP_FVBNJ_G0026369
 protein coding gene Chr2:136634148-136654697 (-)
LP/J MGP_LPJ_G0026509
 protein coding gene Chr2:144741122-144761668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026389
 protein coding gene Chr2:158466298-158487218 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027048
 protein coding gene Chr2:142714591-142735124 (-)
PWK/PhJ MGP_PWKPhJ_G0025488
 protein coding gene Chr2:137673539-137694161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025289
 protein coding gene Chr2:141768286-141788814 (-)
WSB/EiJ MGP_WSBEiJ_G0025825
 protein coding gene Chr2:143693587-143714170 (-)



Homology
more
  • Human Ortholog
    FLRT3, fibronectin leucine rich transmembrane protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FLRT3, fibronectin leucine rich transmembrane protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH21
  • Links
    NCBI Gene ID: 23767
    neXtProt AC: NX_Q9NZU0
    UniProt: Q9NZU0

  • Chr Location
    20p12.1; chr20:14322985-14337847 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 8322
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FLRT3
  • Gene Tree
    Flrt3
Human Diseases
more
  • Diseases
    1 with human FLRT3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 6 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, abnormal embryonic tissue development, disrupted head formation, cardia bifida and abnormal ventral wall closure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1013
  • Tissues
    130
  • cDNA Data
    18
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71436 NCBI Gene Model | MGI Sequence Detail 13279 C57BL/6J ±  kb
    transcript NM_001172160 RefSeq | MGI Sequence Detail 4537 C57BL/6  
    polypeptide Q8BGT1 UniProt | EBI | MGI Sequence Detail 649 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 18
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1924899
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 17
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    02/16/2021
    MGI 6.16     		The Jackson Laboratory