Flrt3
Gene Detail

Symbol

Name
ID

Flrt3
fibronectin leucine rich transmembrane protein 3
MGI:1918686

Synonyms

5530600M07Rik, C430047I10Rik, mKIAA1469

Feature Type

protein coding gene

Genetic Map

Chromosome 2
69.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:140650914-140671469 bp, - strand From VEGA annotation of GRCm38   20556 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:8322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Flrt3

Human
homologs

Human Homolog		FLRT3, fibronectin leucine rich transmembrane protein 3
NCBI Gene ID		23767
neXtProt AC		NX_Q9NZU0
Human Synonyms		HH21
Human Chr (Location)		20p11; chr20:14323993-14337667 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human FLRT3

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, abnormal embryonic tissue development, disrupted head formation, cardia bifida and abnormal ventral wall closure.

 

Interactions

Flrt3 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (5 annotations)

Process	axon guidance, negative chemotaxis
Component	extracellular space
Function	chemorepellent activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (286)    Tissues (83)    Images (56)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	276
Northern blot	10

cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000015600 (Evidence)
Ensembl Gene Model	ENSMUSG00000051379 (Evidence)
Entrez Gene	71436 (Evidence)
DFCI	TC1605599, TC1575859, TC1741168, TC1637606
DoTS	DT.101289113, DT.101734965, DT.487765, DT.91334765
NIA Mouse Gene Index	U023422
PDB	4V2E
Consensus CDS Project	CCDS16806.1
International Mouse Knockout Project Status	Flrt3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015600	VEGA Gene Model | MGI Sequence Detail	20556	C57BL/6J
transcript	OTTMUST00000037050	VEGA | MGI Sequence Detail	3977	Not Applicable
polypeptide	OTTMUSP00000016617	VEGA | MGI Sequence Detail	649	Not Applicable

All sequences(48) RefSeq(4) UniProt(3)

Polymorphisms

SNPs within 2kb(158 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000007562	leucine-rich repeat transmembrane protein FLRT3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203635 Miraoui H, et al., Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 2;92(5):725-43
All references(45)

Other
accession IDs

MGI:1924899