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Flrt3
Gene Detail
Symbol

Name
ID
Flrt3
fibronectin leucine rich transmembrane protein 3
MGI:1918686
Synonyms
5530600M07Rik, C430047I10Rik, mKIAA1469
Feature Type
protein coding gene
Genetic Map
Chromosome 2
69.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:140650914-140671469 bp, - strand
From VEGA annotation of GRCm38

  20556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Human
homologs
Human Homolog FLRT3, fibronectin leucine rich transmembrane protein 3
NCBI Gene ID 23767
neXtProt AC  NX_Q9NZU0
Human Synonyms  HH21
Human Chr (Location)  20p11; chr20:14323993-14337667 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FLRT3
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, abnormal embryonic tissue development, disrupted head formation, cardia bifida and abnormal ventral wall closure.
 
Interactions
Flrt3 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process axon guidance, negative chemotaxis
Component extracellular space
Function chemorepellent activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (286)    Tissues (83)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 276
Northern blot 10
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000015600 (Evidence)
Ensembl Gene ModelENSMUSG00000051379 (Evidence), ENSMUSG00000079021 (Evidence)
Entrez Gene71436 (Evidence)
DFCITC1575859, TC1637606, TC1605599, TC1741168
DoTSDT.101289113, DT.487765, DT.101734965, DT.91334765
NIA Mouse Gene IndexU023422
Consensus CDS ProjectCCDS16806.1
International Mouse Knockout Project StatusFlrt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015600 VEGA Gene Model | MGI Sequence Detail 20556 C57BL/6J ±  kb
transcript OTTMUST00000037050 VEGA | MGI Sequence Detail 3977 Not Applicable 
polypeptide OTTMUSP00000016617 VEGA | MGI Sequence Detail 649 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR003961 Fibronectin, type III
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000007562 leucine-rich repeat transmembrane protein FLRT3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203635 Miraoui H, et al., Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 2;92(5):725-43
All references(45)
Other
accession IDs
MGI:1924899

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory