Flrt3 MGI Mouse Gene Detail - MGI:1918686 - fibronectin leucine rich transmembrane protein 3

Flrt3 Gene Detail

Symbol

Flrt3
Name

fibronectin leucine rich transmembrane protein 3
Synonyms

5530600M07Rik, C430047I10Rik, mKIAA1469

Feature Type

protein coding gene
IDs

MGI:1918686
NCBI Gene: 71436
Gene Overview

MyGene.info: FLRT3

Sequence Map

Chr2:140650914-140671469 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

20556 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 69.20 cM
Mapping Data

3 experiments

Human Ortholog

FLRT3, fibronectin leucine rich transmembrane protein 3

Vertebrate Orthologs

10

Human Ortholog

FLRT3, fibronectin leucine rich transmembrane protein 3
Orthology source: HomoloGene, HGNC
Synonyms

HH21
Links

HGNC:3762

NCBI Gene ID: 23767

neXtProt AC: NX_Q9NZU0

UniProt: Q9NZU0
Chr Location

20p12.1; chr20:14322985-14337847 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8322
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FLRT3
Gene Tree

Flrt3

Diseases

2 with human FLRT3 associations

				Human Disease	Mouse Models
				hypogonadotropic hypogonadism 7 with or without anosmia IDs hypogonadotropic hypogonadism 7 with or without anosmia DOID:0090078 ICD10CM:E23.0 OMIM:146110
				hypogonadotropic hypogonadism 21 with or without anosmia IDs hypogonadotropic hypogonadism 21 with or without anosmia DOID:0090093 ICD10CM:E23.0 OMIM:615271

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 4 alleles in 6 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

9
Genomic Mutations

2 involving Flrt3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, abnormal embryonic tissue development, disrupted head formation, cardia bifida and abnormal ventral wall closure.

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All GO Annotations

46
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

291
Tissues

86
cDNA Data

16
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FLRT3

Xenbase flrt3

ZFIN flrt3

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Flrt3 interacts with 257 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS16806.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000015600	VEGA Gene Model \| MGI Sequence Detail	20556	C57BL/6J	± kb
transcript	OTTMUST00000037051	VEGA \| MGI Sequence Detail	3334	Not Applicable
polypeptide	OTTMUSP00000016618	VEGA \| MGI Sequence Detail	649	Not Applicable

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SNPs within 2kb

157 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000007562 leucine-rich repeat transmembrane protein FLRT3

(term hierarchy)
PDB

4V2E, 4YEB
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR003961 Fibronectin type III

IPR013783 Immunoglobulin-like fold

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain, L domain-like

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 18

cDNA 16

Primer pair 1

Other 1

Microarray probesets 7

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MGI:1924899

Summaries

All 52

Developmental Gene Expression 14

Gene Ontology 10

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:241499 Del Toro D, et al., Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules. Cell. 2017 May 04;169(4):621-635.e16

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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